ID   PTAFR_MACMU             Reviewed;         208 AA.
AC   P35366;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=Platelet-activating factor receptor;
DE            Short=PAF-R;
DE            Short=PAFr;
DE   Flags: Fragment;
GN   Name=PTAFR;
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Behal R.H., Debuysere M.S., Olson M.S.;
RT   "Nucleotide sequence of platelet-activating-factor receptor derived from
RT   HeLa cell genomic DNA and Rhesus monkey genomic DNA.";
RL   Submitted (DEC-1992) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Receptor for platelet activating factor, a chemotactic
CC       phospholipid mediator that possesses potent inflammatory, smooth-muscle
CC       contractile and hypotensive activity. Seems to mediate its action via a
CC       G protein that activates a phosphatidylinositol-calcium second
CC       messenger system.
CC   -!- SUBUNIT: Interacts with ARRB1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; L07333; AAA68893.1; -; mRNA.
DR   AlphaFoldDB; P35366; -.
DR   SMR; P35366; -.
DR   STRING; 9544.ENSMMUP00000015331; -.
DR   eggNOG; ENOG502QTQI; Eukaryota.
DR   HOGENOM; CLU_009579_8_2_1; -.
DR   InParanoid; P35366; -.
DR   Proteomes; UP000006718; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0045028; F:G protein-coupled purinergic nucleotide receptor activity; IBA:GO_Central.
DR   GO; GO:0004992; F:platelet activating factor receptor activity; IEA:InterPro.
DR   GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR002282; PAF_rcpt.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR01153; PAFRECEPTOR.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Chemotaxis; Disulfide bond; G-protein coupled receptor;
KW   Glycoprotein; Membrane; Receptor; Reference proteome; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..>208
FT                   /note="Platelet-activating factor receptor"
FT                   /id="PRO_0000070093"
FT   TOPO_DOM        1..16
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        17..38
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        39..54
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..74
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        75..91
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        92..113
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        114..133
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        134..155
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        156..184
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        185..205
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        206..>208
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        169
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        90..173
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   NON_TER         208
SQ   SEQUENCE   208 AA;  23736 MW;  7985928F70B3C6A1 CRC64;
     MEPHDSSHVD SEFRYTLFPI VYSIIFVLGV IANGYVLWVF ARLYPSKKFN EIKIFMVNLT
     MADMLFLITL PLWIVYYQNG GNWIFPKFLC NLAGCLFFIN TYCSVAFLGV ITYNRFQAVT
     RPIKTAQANT RKRGISLSLV IWVAIVGAAS YFFILDSTNT VPNSAGSGNI TRCFEHYEKG
     SVPVLIIHIF IVFSFFLVFL IILFCNLV