ATP22_YEAST
ID ATP22_YEAST Reviewed; 684 AA.
AC P50273; D6VSY0;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Mitochondrial translation factor ATP22;
DE Flags: Precursor;
GN Name=ATP22; Synonyms=TCM10; OrderedLocusNames=YDR350C; ORFNames=D9476.9;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=MH125;
RA Zhang Y., Robinson K.M., Lemire B.D.;
RL Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169867;
RA Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G.,
RA Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C.,
RA Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F.,
RA Delaveau T., del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M.,
RA Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T.,
RA Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C.,
RA Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S.,
RA Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L.,
RA Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H.,
RA Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M.,
RA Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M.,
RA Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A.,
RA Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G.,
RA Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E.,
RA Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S.,
RA Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D.,
RA Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V.,
RA Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E.,
RA Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M.,
RA Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D.,
RA Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X.,
RA Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A.,
RA Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R.,
RA Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T.,
RA Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L.,
RA Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E.,
RA Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L.,
RA Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M.,
RA Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K.,
RA Mewes H.-W., Zollner A., Zaccaria P.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.";
RL Nature 387:75-78(1997).
RN [3]
RP GENOME REANNOTATION, AND SEQUENCE REVISION TO 592.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=12646576; DOI=10.1074/jbc.m301679200;
RA Helfenbein K.G., Ellis T.P., Dieckmann C.L., Tzagoloff A.;
RT "ATP22, a nuclear gene required for expression of the F0 sector of
RT mitochondrial ATPase in Saccharomyces cerevisiae.";
RL J. Biol. Chem. 278:19751-19756(2003).
RN [5]
RP FUNCTION.
RX PubMed=17110482; DOI=10.1534/genetics.106.065821;
RA Zeng X., Hourset A., Tzagoloff A.;
RT "The Saccharomyces cerevisiae ATP22 gene codes for the mitochondrial ATPase
RT subunit 6-specific translation factor.";
RL Genetics 175:55-63(2007).
CC -!- FUNCTION: Translation factor specific for subunit 6 of the
CC mitochondrial ATPase. Required for assembly of the CF(0) component of
CC the ATPase. {ECO:0000269|PubMed:12646576, ECO:0000269|PubMed:17110482}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000269|PubMed:12646576}; Peripheral membrane protein
CC {ECO:0000269|PubMed:12646576}; Matrix side
CC {ECO:0000269|PubMed:12646576}.
CC -!- SIMILARITY: Belongs to the ATP22 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB64786.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; U32306; AAA74031.1; -; Genomic_DNA.
DR EMBL; U28372; AAB64786.1; ALT_FRAME; Genomic_DNA.
DR EMBL; BK006938; DAA12190.2; -; Genomic_DNA.
DR PIR; S61147; S61147.
DR RefSeq; NP_010637.4; NM_001180658.4.
DR AlphaFoldDB; P50273; -.
DR BioGRID; 32407; 78.
DR DIP; DIP-5246N; -.
DR IntAct; P50273; 4.
DR MINT; P50273; -.
DR STRING; 4932.YDR350C; -.
DR PaxDb; P50273; -.
DR PRIDE; P50273; -.
DR EnsemblFungi; YDR350C_mRNA; YDR350C; YDR350C.
DR GeneID; 851952; -.
DR KEGG; sce:YDR350C; -.
DR SGD; S000002758; ATP22.
DR VEuPathDB; FungiDB:YDR350C; -.
DR eggNOG; ENOG502QUX9; Eukaryota.
DR HOGENOM; CLU_024415_0_0_1; -.
DR InParanoid; P50273; -.
DR OMA; INNCSEN; -.
DR BioCyc; YEAST:G3O-29904-MON; -.
DR PRO; PR:P50273; -.
DR Proteomes; UP000002311; Chromosome IV.
DR RNAct; P50273; protein.
DR GO; GO:0005743; C:mitochondrial inner membrane; IDA:SGD.
DR GO; GO:0045182; F:translation regulator activity; IMP:SGD.
DR GO; GO:0070131; P:positive regulation of mitochondrial translation; IMP:SGD.
DR GO; GO:0070071; P:proton-transporting two-sector ATPase complex assembly; IMP:SGD.
DR InterPro; IPR017207; Atp22.
DR PIRSF; PIRSF037437; Atp22; 1.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Transit peptide; Translation regulation.
FT TRANSIT 1..56
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 57..684
FT /note="Mitochondrial translation factor ATP22"
FT /id="PRO_0000072452"
SQ SEQUENCE 684 AA; 79756 MW; A88992848F8F49A4 CRC64;
MLKCICRVYS QPLAQMVTSP LFKHMGSAGT YTILPITNLR HLSTKNCPLK IKSNRSEPLQ
FGDFERQVPC SRKSGSSKNV QKRLYELRQL KTVLSETFGV TEYASFFESL RNALHINNCS
ENEKKKLLYD IILHQHELYP EVARKIGFYL PGEVHRWFWY HIPKSESFNH YLFLLKSDVL
LFTSNYCTRF TNRLIKGTEM ERQLATFQIF LHDETNIKFI MEKVLKLHTF DSLIALVNGL
VKAKNFRFIK VFIQALLQKL EQHCYSGKDG AKQKNLRYVK FNNTLLYYLL KSGNVELFIK
TFQEELKFIV SSGLLNHIDG NEHILNFPIH HYLNLLRISN RQEELFNVIS CLQSSPLMKY
KLFKEFLMGE LIASFQAFRD PKLVCKYLLS SYSSKASANI LNALGIWGWL YHSKSTTLTA
PTLARELKNK NNILPNTMRI GSPVTVPILT ELYRSLLSSS SVSLESGQFK NCLLDLYYKY
KSFLSEEAHK YRYWRNDTGI LNVFLNYIRF QAREPRLAYN VLLDFYSQPF AKKVVLTTTL
CPFSIVAYKN HTLTQAELSE LLQVMHKNGV PLTFKFCSAM VMHYVKMRDE KGARSWYNKI
LFGGFEIRHM ALIQIIKDQG WPFPKNFDET LLTELVENNN IKEPTDSTLF TDEDMFEEDG
KPRFNDDDVN KCTNIIRETL KSLN
