ID   PTAR2_PESFW             Reviewed;         444 AA.
AC   A0A067XMN9; W3WT12;
DT   31-JAN-2018, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2014, sequence version 1.
DT   25-MAY-2022, entry version 23.
DE   RecName: Full=Pestheic acid cluster transcriptional regulator 2 {ECO:0000303|PubMed:24302702};
GN   Name=ptaR2 {ECO:0000303|PubMed:24302702}; ORFNames=PFICI_10833;
OS   Pestalotiopsis fici (strain W106-1 / CGMCC3.15140).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Xylariomycetidae; Xylariales; Sporocadaceae; Pestalotiopsis.
OX   NCBI_TaxID=1229662;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=W106-1 / CGMCC3.15140;
RX   PubMed=24302702; DOI=10.1002/cbic.201300626;
RA   Xu X., Liu L., Zhang F., Wang W., Li J., Guo L., Che Y., Liu G.;
RT   "Identification of the first diphenyl ether gene cluster for pestheic acid
RT   biosynthesis in plant endophyte Pestalotiopsis fici.";
RL   ChemBioChem 15:284-292(2014).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=W106-1 / CGMCC3.15140;
RX   PubMed=25623211; DOI=10.1186/s12864-014-1190-9;
RA   Wang X., Zhang X., Liu L., Xiang M., Wang W., Sun X., Che Y., Guo L.,
RA   Liu G., Guo L., Wang C., Yin W.B., Stadler M., Zhang X., Liu X.;
RT   "Genomic and transcriptomic analysis of the endophytic fungus
RT   Pestalotiopsis fici reveals its lifestyle and high potential for synthesis
RT   of natural products.";
RL   BMC Genomics 16:28-28(2015).
CC   -!- FUNCTION: Transcription factor that, with ptaR1 and ptaR3, coregulates
CC       the expression of the gene cluster that mediates the biosynthesis of
CC       pestheic acid, a diphenyl ether which is a biosynthetic precursor of
CC       the unique chloropupukeananes (PubMed:24302702).
CC       {ECO:0000305|PubMed:24302702}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
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DR   EMBL; KC145148; AGO59037.1; -; Genomic_DNA.
DR   EMBL; KI912116; ETS76959.1; -; Genomic_DNA.
DR   RefSeq; XP_007837605.1; XM_007839414.1.
DR   AlphaFoldDB; A0A067XMN9; -.
DR   SMR; A0A067XMN9; -.
DR   EnsemblFungi; ETS76959; ETS76959; PFICI_10833.
DR   GeneID; 19275846; -.
DR   KEGG; pfy:PFICI_10833; -.
DR   eggNOG; ENOG502SUW5; Eukaryota.
DR   OMA; VRCTKER; -.
DR   OrthoDB; 1396569at2759; -.
DR   Proteomes; UP000030651; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0045122; P:aflatoxin biosynthetic process; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR013700; AflR.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF08493; AflR; 1.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..444
FT                   /note="Pestheic acid cluster transcriptional regulator 2"
FT                   /id="PRO_0000443053"
FT   DNA_BIND        36..63
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          326..348
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..28
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        329..348
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   444 AA;  48761 MW;  456C8768BDA244C5 CRC64;
     MEAADPNNNL TITSPSTLLS NPTQPPAQPL KLRDSCHACA SSKVKCHKEK PTCSRCRKRG
     ITCEYFAHRR PGRKQENRAK DTTNHVERQE NTTAVEMLDL NWPAPDFSTQ TSIANDNLDV
     FHDIFVPPDQ LNNGLTDFTI DFDDFDIQSD PAEIASLPDT SSLESMFVTS PTAPTDTITP
     NVITPNVGLS VLEGLPDTTH HTQAINLASY IQTPPTEKTP DSRIKHLEEN KDPCMTRALS
     FLTQLSESTS RICKTSETGC SGTNKKSLPE SLDGIIAENR RLLEAMSNIL QCRCSEDDDL
     LCIQAIVASK ILNLYASAIE IKPSPARVGS GVSTHTTAGQ YEPQVEQQLS TRTHPQLASG
     RDPIRMAAQS VLGELHRVQR LLSQMLQKSK DNETMRRKGS ENGLRAVADK VPLTSGVSFG
     SIEADLRYKL GKLSIEIITL LRGA