ID   PTAR3_PESFW             Reviewed;         564 AA.
AC   A0A067XMT7; W3WT17;
DT   31-JAN-2018, integrated into UniProtKB/Swiss-Prot.
DT   31-JAN-2018, sequence version 2.
DT   25-MAY-2022, entry version 16.
DE   RecName: Full=Pestheic acid cluster transcriptional regulator 3 {ECO:0000303|PubMed:24302702};
GN   Name=ptaR3 {ECO:0000303|PubMed:24302702}; ORFNames=PFICI_10838;
OS   Pestalotiopsis fici (strain W106-1 / CGMCC3.15140).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Xylariomycetidae; Xylariales; Sporocadaceae; Pestalotiopsis.
OX   NCBI_TaxID=1229662;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=W106-1 / CGMCC3.15140;
RX   PubMed=24302702; DOI=10.1002/cbic.201300626;
RA   Xu X., Liu L., Zhang F., Wang W., Li J., Guo L., Che Y., Liu G.;
RT   "Identification of the first diphenyl ether gene cluster for pestheic acid
RT   biosynthesis in plant endophyte Pestalotiopsis fici.";
RL   ChemBioChem 15:284-292(2014).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=W106-1 / CGMCC3.15140;
RX   PubMed=25623211; DOI=10.1186/s12864-014-1190-9;
RA   Wang X., Zhang X., Liu L., Xiang M., Wang W., Sun X., Che Y., Guo L.,
RA   Liu G., Guo L., Wang C., Yin W.B., Stadler M., Zhang X., Liu X.;
RT   "Genomic and transcriptomic analysis of the endophytic fungus
RT   Pestalotiopsis fici reveals its lifestyle and high potential for synthesis
RT   of natural products.";
RL   BMC Genomics 16:28-28(2015).
CC   -!- FUNCTION: Transcription factor that, with ptaR1 and ptaR2, coregulates
CC       the expression of the gene cluster that mediates the biosynthesis of
CC       pestheic acid, a diphenyl ether which is a biosynthetic precursor of
CC       the unique chloropupukeananes (PubMed:24302702).
CC       {ECO:0000305|PubMed:24302702}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AGO59048.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; KC145148; AGO59048.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; KI912116; ETS76964.1; -; Genomic_DNA.
DR   RefSeq; XP_007837610.1; XM_007839419.1.
DR   AlphaFoldDB; A0A067XMT7; -.
DR   EnsemblFungi; ETS76964; ETS76964; PFICI_10838.
DR   GeneID; 19275851; -.
DR   KEGG; pfy:PFICI_10838; -.
DR   eggNOG; ENOG502SNKF; Eukaryota.
DR   OMA; RSKEGCW; -.
DR   OrthoDB; 411827at2759; -.
DR   Proteomes; UP000030651; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR021858; Fun_TF.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF11951; Fungal_trans_2; 1.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..564
FT                   /note="Pestheic acid cluster transcriptional regulator 3"
FT                   /id="PRO_0000443044"
FT   DNA_BIND        11..38
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          71..123
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        95..123
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   564 AA;  63274 MW;  078A4ADD2E7AB45A CRC64;
     MSNPVRSKGG CWTCRLRRKK CDEGKPECTT CQALSITCYG YGPKPEWMDN GDAEKDVANS
     LKHIVRYTSR RTSSRYRVPP GQKANPKLAP KVHAAASTPS TNTSHSTETT PPSDNGFYDT
     AESPLSPNGA QHLTIATIPA EDSILLMHFL DKVFPLQYPM YRPDILEGGR GWLLALLLQT
     KSLYHAALAL SSYHRRMLVF ERISEQCRAT AAVQQEKHLE TCLNEVRQAM VILDQRTRQR
     KSYDGMGTVT SIVQLVFFEL FAGQDHAWRT HLNAAIDVYD QNCRDKLEHL DLSEASKTIL
     RNDQRLAVDG ALVTQEVTTF RFMGGSIIWL DILSSLAAGS VPRLLSYHQG VLDAASQVKL
     ENIMGCKNWL MCQIGRIAAL QGHRRQDGWT SQRHGIKLHS IAADIKSEIE SGMAREALES
     LNIQTSDSCG INNSSTNSVT LTTRMFAFMA IIHLHLVTHD FERLDNLRET IADAIRLLQS
     QVPCSMIPVI VAPLFIIGCV AAQGDEQSLF RASLASDTSQ HRLYRHRKDV LSALEEIWSK
     RQTSTDYTWN DVLDMGQHKY LLFL