ID   PTAS_THETC              Reviewed;         328 AA.
AC   Q59330; D9TNN7; O65980;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   30-NOV-2010, sequence version 2.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Phosphate acetyltransferase;
DE            EC=2.3.1.8;
DE   AltName: Full=Phosphotransacetylase;
GN   Name=pta; Synonyms=ptaA; OrderedLocusNames=Tthe_1502;
OS   Thermoanaerobacterium thermosaccharolyticum (strain ATCC 7956 / DSM 571 /
OS   NCIMB 9385 / NCA 3814 / NCTC 13789 / WDCM 00135 / 2032) (Clostridium
OS   thermosaccharolyticum).
OC   Bacteria; Firmicutes; Clostridia; Thermoanaerobacterales;
OC   Thermoanaerobacterales Family III. Incertae Sedis; Thermoanaerobacterium.
OX   NCBI_TaxID=580327;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 7956 / DSM 571 / NCIMB 9385 / NCA 3814 / NCTC 13789 / WDCM
RC   00135 / 2032;
RA   Joerges A., Bronnenmeier K., Lottspeich F., Staudenbauer W.L.;
RL   Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 7956 / DSM 571 / NCIMB 9385 / NCA 3814 / NCTC 13789 / WDCM
RC   00135 / 2032;
RA   van Rinsum A.;
RL   Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 7956 / DSM 571 / NCIMB 9385 / NCA 3814 / NCTC 13789 / WDCM
RC   00135 / 2032;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA   Pitluck S., Teshima H., Detter J.C., Han C., Tapia R., Land M., Hauser L.,
RA   Chang Y.-J., Jeffries C., Kyrpides N., Ivanova N., Mikhailova N.,
RA   Hemme C.L., Woyke T.;
RT   "Complete sequence of Thermoanaerobacterium thermosaccharolyticum DSM
RT   571.";
RL   Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetyl-CoA + phosphate = acetyl phosphate + CoA;
CC         Xref=Rhea:RHEA:19521, ChEBI:CHEBI:22191, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57288; EC=2.3.1.8;
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis;
CC       acetyl-CoA from acetate: step 2/2.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the phosphate acetyltransferase and
CC       butyryltransferase family. {ECO:0000305}.
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DR   EMBL; Z71384; CAA95985.1; -; Genomic_DNA.
DR   EMBL; AJ004870; CAA06174.1; -; Genomic_DNA.
DR   EMBL; CP002171; ADL69012.1; -; Genomic_DNA.
DR   RefSeq; WP_013297979.1; NC_014410.1.
DR   AlphaFoldDB; Q59330; -.
DR   SMR; Q59330; -.
DR   STRING; 580327.Tthe_1502; -.
DR   PRIDE; Q59330; -.
DR   EnsemblBacteria; ADL69012; ADL69012; Tthe_1502.
DR   KEGG; ttm:Tthe_1502; -.
DR   eggNOG; COG0280; Bacteria.
DR   HOGENOM; CLU_019723_0_1_9; -.
DR   OMA; TMLVKMG; -.
DR   OrthoDB; 1301815at2; -.
DR   UniPathway; UPA00340; UER00459.
DR   Proteomes; UP000001626; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008959; F:phosphate acetyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006085; P:acetyl-CoA biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.40.50.10750; -; 1.
DR   Gene3D; 3.40.50.10950; -; 1.
DR   InterPro; IPR012147; P_Ac_Bu_trans.
DR   InterPro; IPR004614; P_AcTrfase.
DR   InterPro; IPR042113; P_AcTrfase_dom1.
DR   InterPro; IPR042112; P_AcTrfase_dom2.
DR   InterPro; IPR002505; PTA_PTB.
DR   Pfam; PF01515; PTA_PTB; 1.
DR   PIRSF; PIRSF000428; P_Ac_trans; 1.
DR   TIGRFAMs; TIGR00651; pta; 1.
PE   3: Inferred from homology;
KW   Acyltransferase; Cytoplasm; Reference proteome; Transferase.
FT   CHAIN           1..328
FT                   /note="Phosphate acetyltransferase"
FT                   /id="PRO_0000179127"
FT   CONFLICT        31..32
FT                   /note="AA -> GP (in Ref. 2; CAA06174)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        91
FT                   /note="I -> L (in Ref. 1; CAA95985)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        113..117
FT                   /note="EGYAD -> RRLCS (in Ref. 1; CAA95985)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        125
FT                   /note="H -> D (in Ref. 1; CAA95985)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        137
FT                   /note="I -> N (in Ref. 1; CAA95985)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        247..248
FT                   /note="AL -> DV (in Ref. 1; CAA95985 and 2; CAA06174)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   328 AA;  34945 MW;  11C4C57B4DA39D17 CRC64;
     MSIIQSIIEK AKSNKKKIVL PEGAEPRTLK AADIVLKEGI ADLVLLGNAD EIRNAAEGLD
     ISKAEIIDPL KSEKFDKYAT DFYELRKNKG ITLEKAKETI KDNIYFGCMM VKEGYADGLV
     SGAIHATADL LRPAFQIVKT APGAKIVSSF FIMEVPNCEF GENGVFLFAD CAVNPSPNAE
     ELASIAVQSA NTAKTLLGME PRVAMLSFST KGSASHELVD KVRTATEIAK NLIPDVAIDG
     ELQLDAALVK EVAELKAPGS PVAGRANVLI FPDLQAGNIG YKLVQRLAKA NAIGPITQGM
     GAPVNDLSRG CSYKDIVDVI ATTAVQAQ