PTA_SYNY3
ID PTA_SYNY3 Reviewed; 697 AA.
AC P73662;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Phosphate acetyltransferase;
DE EC=2.3.1.8;
DE AltName: Full=Phosphotransacetylase;
GN Name=pta; OrderedLocusNames=slr2132;
OS Synechocystis sp. (strain PCC 6803 / Kazusa).
OC Bacteria; Cyanobacteria; Synechococcales; Merismopediaceae; Synechocystis;
OC unclassified Synechocystis.
OX NCBI_TaxID=1111708;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PCC 6803 / Kazusa;
RX PubMed=8905231; DOI=10.1093/dnares/3.3.109;
RA Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y.,
RA Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T.,
RA Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.,
RA Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence analysis of the genome of the unicellular cyanobacterium
RT Synechocystis sp. strain PCC6803. II. Sequence determination of the entire
RT genome and assignment of potential protein-coding regions.";
RL DNA Res. 3:109-136(1996).
CC -!- FUNCTION: Involved in acetate metabolism. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + phosphate = acetyl phosphate + CoA;
CC Xref=Rhea:RHEA:19521, ChEBI:CHEBI:22191, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57288; EC=2.3.1.8;
CC -!- PATHWAY: Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis;
CC acetyl-CoA from acetate: step 2/2.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- DOMAIN: The N-terminal region seems to be important for proper
CC quaternary structure. The C-terminal region contains the substrate-
CC binding site (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the CobB/CobQ family.
CC {ECO:0000305}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the phosphate
CC acetyltransferase and butyryltransferase family. {ECO:0000305}.
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DR EMBL; BA000022; BAA17707.1; -; Genomic_DNA.
DR PIR; S77149; S77149.
DR AlphaFoldDB; P73662; -.
DR SMR; P73662; -.
DR STRING; 1148.1652788; -.
DR PaxDb; P73662; -.
DR PRIDE; P73662; -.
DR EnsemblBacteria; BAA17707; BAA17707; BAA17707.
DR KEGG; syn:slr2132; -.
DR eggNOG; COG0280; Bacteria.
DR eggNOG; COG0857; Bacteria.
DR InParanoid; P73662; -.
DR OMA; FFMCLAD; -.
DR PhylomeDB; P73662; -.
DR UniPathway; UPA00340; UER00459.
DR Proteomes; UP000001425; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008959; F:phosphate acetyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006085; P:acetyl-CoA biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.1390.20; -; 1.
DR Gene3D; 3.40.50.10750; -; 1.
DR Gene3D; 3.40.50.10950; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR010766; DRTGG.
DR InterPro; IPR016475; P-Actrans_bac.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004614; P_AcTrfase.
DR InterPro; IPR042113; P_AcTrfase_dom1.
DR InterPro; IPR042112; P_AcTrfase_dom2.
DR InterPro; IPR002505; PTA_PTB.
DR InterPro; IPR028979; Ser_kin/Pase_Hpr-like_N_sf.
DR Pfam; PF07085; DRTGG; 1.
DR Pfam; PF01515; PTA_PTB; 1.
DR PIRSF; PIRSF006107; PhpActrans_proteobac; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF75138; SSF75138; 1.
DR TIGRFAMs; TIGR00651; pta; 1.
PE 3: Inferred from homology;
KW Acyltransferase; Cytoplasm; Reference proteome; Transferase.
FT CHAIN 1..697
FT /note="Phosphate acetyltransferase"
FT /id="PRO_0000179148"
FT REGION 374..697
FT /note="Phosphate acetyltransferase"
SQ SEQUENCE 697 AA; 76477 MW; F77B4439F5DB671A CRC64;
MTSSLYLSTT EARSGKSLVV LGILDLILKK TTRIAYFRPI IQDPVNGKHD NNIILVLENF
RLQQTYTDSF GLYFHEAVSL ASDGAIDQVL DRILAKYRHL ADQVDFILCE GSDYLGEESA
FEFDLNTTIA KMLNCPILLL GNAMGNTIAD SLQPIDMALN SYDQESCQVV GVIINRVQPE
LATEIQAQLE QRYGDRPMVL GTIPQDIMLK SLRLREIVSG LNAQVLSGAD LLDNLVYHHL
VVAMHIAHAL HWLHEKNTLI ITPGDRGDII LGVMQAHRSL NYPSIAGILL TADYHPEPAI
MKLIEGLPDA PPLLLTSTHT HETSARLETL HPALSPTDNY KIRHSIALFQ QQIDGEKLLN
YLKTIRSKGI TPKLFLYNLV QAATAAQRHI VLPEGEEIRI LKAAASLINH GIVRLTLLGN
IEAIEQTVKI NHIDLDLSKV RLINPKTSPD RERYAETYYQ LRKHKGVTLA MARDILTDIS
YFGTMMVHLG EADGMVSGSV NTTQHTVRPA LQIIKTQPGF SLVSSVFFMC LEDRVLVYGD
CAVNPDPNAE QLAEIALTSA ATAKNFGIEP RVALLSYSSG SSGQGADVEK VRQATAIAKE
REPDLALEGP IQYDAAVDST VAAQKMPGSA VAGKATVFIF PDLNTGNNTY KAVQRETKAI
AIGPILQGLN KPVNDLSRGC LVEDIINTVV ITALQVK