PTBP3_ARATH
ID PTBP3_ARATH Reviewed; 432 AA.
AC Q6ICX4;
DT 13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Polypyrimidine tract-binding protein homolog 3;
GN OrderedLocusNames=At1g43190; ORFNames=F1I21.14;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Shinn P., Chen H., Cheuk R.F., Kim C.J., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays a role in pre-mRNA splicing. Binds to the
CC polypyrimidine tract of introns. May promote the binding of U2 snRNP to
CC pre-mRNA (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=Q6ICX4-1; Sequence=Displayed;
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DR EMBL; AC005687; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002684; AEE31961.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE31962.1; -; Genomic_DNA.
DR EMBL; BT014899; AAT44975.1; -; mRNA.
DR EMBL; BT015028; AAT70479.1; -; mRNA.
DR RefSeq; NP_001077672.1; NM_001084203.1. [Q6ICX4-1]
DR RefSeq; NP_175010.2; NM_103470.5. [Q6ICX4-1]
DR AlphaFoldDB; Q6ICX4; -.
DR SMR; Q6ICX4; -.
DR BioGRID; 26143; 1.
DR STRING; 3702.AT1G43190.1; -.
DR PaxDb; Q6ICX4; -.
DR PRIDE; Q6ICX4; -.
DR ProteomicsDB; 226042; -. [Q6ICX4-1]
DR EnsemblPlants; AT1G43190.1; AT1G43190.1; AT1G43190. [Q6ICX4-1]
DR EnsemblPlants; AT1G43190.2; AT1G43190.2; AT1G43190. [Q6ICX4-1]
DR GeneID; 840918; -.
DR Gramene; AT1G43190.1; AT1G43190.1; AT1G43190. [Q6ICX4-1]
DR Gramene; AT1G43190.2; AT1G43190.2; AT1G43190. [Q6ICX4-1]
DR KEGG; ath:AT1G43190; -.
DR Araport; AT1G43190; -.
DR TAIR; locus:2018630; AT1G43190.
DR eggNOG; KOG1190; Eukaryota.
DR HOGENOM; CLU_015171_6_2_1; -.
DR InParanoid; Q6ICX4; -.
DR PhylomeDB; Q6ICX4; -.
DR PRO; PR:Q6ICX4; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q6ICX4; baseline and differential.
DR Genevisible; Q6ICX4; AT.
DR GO; GO:0005737; C:cytoplasm; IDA:TAIR.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0000932; C:P-body; IDA:TAIR.
DR GO; GO:0003729; F:mRNA binding; IDA:TAIR.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0043484; P:regulation of RNA splicing; IDA:TAIR.
DR GO; GO:0006417; P:regulation of translation; IEP:TAIR.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR CDD; cd12687; RRM1_PTBPH3; 1.
DR CDD; cd12692; RRM2_PTBPH3; 1.
DR CDD; cd12698; RRM3_PTBPH3; 1.
DR Gene3D; 3.30.70.330; -; 4.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR021790; PTBP1-like_RRM2.
DR InterPro; IPR034795; PTBPH3_RRM1.
DR InterPro; IPR034796; PTBPH3_RRM2.
DR InterPro; IPR034797; PTBPH3_RRM3.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR Pfam; PF00076; RRM_1; 2.
DR Pfam; PF11835; RRM_8; 1.
DR SMART; SM00360; RRM; 4.
DR SUPFAM; SSF54928; SSF54928; 3.
DR PROSITE; PS50102; RRM; 3.
PE 2: Evidence at transcript level;
KW Alternative splicing; mRNA processing; mRNA splicing; Nucleus;
KW Reference proteome; Repeat; RNA-binding.
FT CHAIN 1..432
FT /note="Polypyrimidine tract-binding protein homolog 3"
FT /id="PRO_0000081743"
FT DOMAIN 6..80
FT /note="RRM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 98..187
FT /note="RRM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 245..319
FT /note="RRM 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 355..429
FT /note="RRM 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
SQ SEQUENCE 432 AA; 48234 MW; CB08B41B0A370CA0 CRC64;
MAESSKVVHV RNVGHEISEN DLLQLFQPFG VITKLVMLRA KNQALLQMQD VSSAVSALQF
FTNVQPTIRG RNVYVQFSSH QELTTIEQNI HGREDEPNRI LLVTIHHMLY PITVDVLHQV
FSPYGFVEKL VTFQKSAGFQ ALIQYQVQQC AASARTALQG RNIYDGCCQL DIQFSNLEEL
QVNYNNDRSR DYTNPNLPAE QKGRSSHPCY GDTGVAYPQM ANTSAIAAAF GGGLPPGITG
TNDRCTVLVS NLNADSIDED KLFNLFSLYG NIVRIKLLRN KPDHALVQMG DGFQAELAVH
FLKGAMLFGK RLEVNFSKHP NITPGTDSHD YVNSNLNRFN RNAAKNYRYC CSPTKMIHLS
TLPQDVTEEE VMNHVQEHGA VVNTKVFEMN GKKQALVQFE NEEEAAEALV CKHATSLGGS
IIRISFSQLQ TI
