PTB_CLOB8
ID PTB_CLOB8 Reviewed; 302 AA.
AC Q05624; A6LPW3;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 25-MAY-2022, entry version 102.
DE RecName: Full=Phosphate butyryltransferase;
DE EC=2.3.1.19;
DE AltName: Full=Phosphotransbutyrylase;
GN Name=ptb; OrderedLocusNames=Cbei_0203;
OS Clostridium beijerinckii (strain ATCC 51743 / NCIMB 8052) (Clostridium
OS acetobutylicum).
OC Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=290402;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8396545; DOI=10.1016/0378-1119(93)90677-u;
RA Oultram J.D., Burr I.D., Elmore M.J., Minton N.P.;
RT "Cloning and sequence analysis of the genes encoding phosphotransbutyrylase
RT and butyrate kinase from Clostridium acetobutylicum NCIMB 8052.";
RL Gene 131:107-112(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51743 / NCIMB 8052;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Sims D., Brettin T., Bruce D., Tapia R., Brainard J., Schmutz J.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Bennet G.,
RA Cann I., Chen J.-S., Contreras A.L., Jones D., Kashket E., Mitchell W.,
RA Stoddard S., Schwarz W., Qureshi N., Young M., Shi Z., Ezeji T., White B.,
RA Blaschek H., Richardson P.;
RT "Complete sequence of Clostridium beijerinckii NCIMB 8052.";
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the conversion of butyryl-CoA through butyryl
CC phosphate to butyrate.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=butanoyl-CoA + phosphate = butanoyl phosphate + CoA;
CC Xref=Rhea:RHEA:20892, ChEBI:CHEBI:43474, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:57371, ChEBI:CHEBI:58079; EC=2.3.1.19;
CC -!- PATHWAY: Lipid metabolism; butanoate metabolism.
CC -!- SIMILARITY: Belongs to the phosphate acetyltransferase and
CC butyryltransferase family. {ECO:0000305}.
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DR EMBL; L04468; AAA52080.1; -; Genomic_DNA.
DR EMBL; CP000721; ABR32393.1; -; Genomic_DNA.
DR RefSeq; WP_011967555.1; NC_009617.1.
DR AlphaFoldDB; Q05624; -.
DR SMR; Q05624; -.
DR STRING; 290402.Cbei_0203; -.
DR EnsemblBacteria; ABR32393; ABR32393; Cbei_0203.
DR GeneID; 66343096; -.
DR KEGG; cbe:Cbei_0203; -.
DR eggNOG; COG0280; Bacteria.
DR HOGENOM; CLU_056531_0_0_9; -.
DR OMA; CIVDGPF; -.
DR UniPathway; UPA00863; -.
DR Proteomes; UP000000565; Chromosome.
DR GO; GO:0050182; F:phosphate butyryltransferase activity; IDA:CACAO.
DR GO; GO:0019605; P:butyrate metabolic process; IEA:UniProtKB-UniPathway.
DR InterPro; IPR012147; P_Ac_Bu_trans.
DR InterPro; IPR014079; Phosphate_butyryltransferase.
DR InterPro; IPR002505; PTA_PTB.
DR Pfam; PF01515; PTA_PTB; 1.
DR PIRSF; PIRSF000428; P_Ac_trans; 1.
DR TIGRFAMs; TIGR02706; P_butyryltrans; 1.
PE 3: Inferred from homology;
KW Acyltransferase; Transferase.
FT CHAIN 1..302
FT /note="Phosphate butyryltransferase"
FT /id="PRO_0000179153"
SQ SEQUENCE 302 AA; 32442 MW; 52C3A7BFB187C1FF CRC64;
MSKNFDELLS RLKEVPTKKV AVAVAQDEPV LEAIKEATEN NIAQAILVGD KQQIHEIAKK
INLDLSDYEI MDIKDPKKAT LEAVKLVSSG HADMLMKGLV DTATFLRSVL NKEVGLRTGK
LMSHVAVFDV EGWDRLLFLT DAAFNTYPEF KDKVGMINNA VVVAHACGID VPRVAPICPV
EVVNTSMQST VDAALLAKMS DRGQIKGCVI DGPFALDNAI SEEAAHHKGV TGSVAGKADI
LLLPNIEAAN VMYKTLTYFS KSRNGGLLVG TSAPVILTSR ADSFETKVNS IALAALVAAR
NK