ID   PTC1_CYNPY              Reviewed;         257 AA.
AC   O42335;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Protein patched homolog 1;
DE            Short=PTC1;
DE   Flags: Fragment;
GN   Name=PTC1;
OS   Cynops pyrrhogaster (Japanese fire-bellied newt) (Molge pyrrhogaster).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Caudata; Salamandroidea; Salamandridae; Pleurodelinae; Cynops.
OX   NCBI_TaxID=8330;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Neuroretina;
RX   PubMed=9237688; DOI=10.1016/s0014-5793(97)00645-5;
RA   Takabatake T., Ogawa M., Takahashi T.C., Mizuno M., Okamoto M.,
RA   Takeshima K.;
RT   "Hedgehog and patched gene expression in adult ocular tissues.";
RL   FEBS Lett. 410:485-489(1997).
CC   -!- FUNCTION: Acts as a receptor for sonic hedgehog (SHH), indian hedgehog
CC       (IHH) and desert hedgehog (DHH). Associates with the smoothened protein
CC       (SMO) to transduce the hedgehog's proteins signal (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: In the eye, detected in neural retina, iris,
CC       retinal pigment epithelium, but not in lens.
CC   -!- INDUCTION: Activated by Sonic hedgehog.
CC   -!- PTM: Glycosylation is necessary for SHH binding. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the patched family. {ECO:0000305}.
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DR   EMBL; AB000848; BAA21678.1; -; mRNA.
DR   AlphaFoldDB; O42335; -.
DR   SMR; O42335; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR000731; SSD.
DR   PROSITE; PS50156; SSD; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Receptor; Transmembrane; Transmembrane helix.
FT   CHAIN           <1..>257
FT                   /note="Protein patched homolog 1"
FT                   /id="PRO_0000205968"
FT   TOPO_DOM        <1..199
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        200..220
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        221..235
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        236..256
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          201..>257
FT                   /note="SSD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00199"
FT   CARBOHYD        75
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        114
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        177
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   NON_TER         1
FT   NON_TER         257
SQ   SEQUENCE   257 AA;  28480 MW;  81C00FCC85D4633C CRC64;
     AKLQTGTAYL PGKHAPLQWT QFDPLEFLEE LKKINYQTDS WEELLNKAEV GQGYMNRPCL
     NPTDPECPVT APNKNSTKPP DVALILSGGC YGLSKKYMRW QEELIVGGTV KNSNGTLLRA
     QALQTMFQLM TPKQMYEHFR GYEDVLHINW NEDKAAAILE AWQRMYVEVV HQSVPQNSTQ
     KVLSFTTTTL DDILKSFSDI SVIRVASGYL LMLAYACLTM LRWDCAKSQG AVGLAGVLLV
     ALSVAAGLGL CSLIGIS