ID   PTC2_CYNPY              Reviewed;         255 AA.
AC   O42334;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Protein patched homolog 2;
DE            Short=PTC2;
DE   Flags: Fragment;
GN   Name=PTC2;
OS   Cynops pyrrhogaster (Japanese fire-bellied newt) (Molge pyrrhogaster).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Caudata; Salamandroidea; Salamandridae; Pleurodelinae; Cynops.
OX   NCBI_TaxID=8330;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Neuroretina;
RX   PubMed=9237688; DOI=10.1016/s0014-5793(97)00645-5;
RA   Takabatake T., Ogawa M., Takahashi T.C., Mizuno M., Okamoto M.,
RA   Takeshima K.;
RT   "Hedgehog and patched gene expression in adult ocular tissues.";
RL   FEBS Lett. 410:485-489(1997).
CC   -!- FUNCTION: May act as a receptor for sonic hedgehog (SHH).
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: In the eye, detected in neural retina, iris,
CC       retinal pigment epithelium, but not in lens.
CC   -!- INDUCTION: Activated by hedgehog.
CC   -!- SIMILARITY: Belongs to the patched family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB000846; BAA23305.1; -; mRNA.
DR   AlphaFoldDB; O42334; -.
DR   SMR; O42334; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR000731; SSD.
DR   PROSITE; PS50156; SSD; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Receptor; Transmembrane; Transmembrane helix.
FT   CHAIN           <1..>255
FT                   /note="Protein patched homolog 2"
FT                   /id="PRO_0000205972"
FT   TOPO_DOM        <1..197
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        198..218
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        219..227
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        228..248
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        249..>255
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          199..>255
FT                   /note="SSD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00199"
FT   CARBOHYD        147
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        175
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   NON_TER         1
FT   NON_TER         255
SQ   SEQUENCE   255 AA;  28392 MW;  715139F607403CB2 CRC64;
     SLLQGGSAYL PGRPEIQWKN LNPMQLMEEL GQFTSVDGFK EMLDKADVGQ AYMERPCLDP
     MDPQCPESAP NKQKRRVPNI AQELAGGCYG FSKRFMHWQE ELILGGTVRD SQDRLLSAEA
     LQTMFLLMSS RQLYEHFRDN YEIHDINWTE EKAAAILETW QRKFVELAQQ SAPENSSQII
     HAFSTTTLND IMKSFSDVSV IRVAGGYLLM LAYACVTMLR WDCTKSQGAV GLAGVLLVAL
     SVASGLGLCS LLGIS