PTC2_HUMAN
ID PTC2_HUMAN Reviewed; 1203 AA.
AC Q9Y6C5; O95341; O95856; Q53Z57; Q5QP87; Q6UX14;
DT 24-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2001, sequence version 2.
DT 03-AUG-2022, entry version 176.
DE RecName: Full=Protein patched homolog 2;
DE Short=PTC2;
GN Name=PTCH2; ORFNames=UNQ560/PRO1121/PRO57079;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=9811851; DOI=10.1073/pnas.95.23.13630;
RA Carpenter D., Stone D.M., Brush J., Ryan A., Armanini M., Frantz G.,
RA Rosenthal A., de Sauvage F.J.;
RT "Characterization of two patched receptors for the vertebrate hedgehog
RT protein family.";
RL Proc. Natl. Acad. Sci. U.S.A. 95:13630-13634(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND INVOLVEMENT IN MDB AND BCC.
RX PubMed=9931336; DOI=10.1093/hmg/8.2.291;
RA Smyth I., Narang M.A., Evans T., Heimann C., Nakamura Y.,
RA Chenevix-Trench G., Pietsch T., Wicking C., Wainwright B.J.;
RT "Isolation and characterization of human patched 2 (PTCH2), a putative
RT tumour suppressor gene in basal cell carcinoma and medulloblastoma on
RT chromosome 1p32.";
RL Hum. Mol. Genet. 8:291-297(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RX PubMed=10029063;
RA Zaphiropoulos P.G., Unden A.B., Rahnama F., Hollingsworth R.E.,
RA Toftgard R.;
RT "PTCH2, a novel human patched gene, undergoing alternative splicing and up-
RT regulated in basal cell carcinomas.";
RL Cancer Res. 59:787-792(1999).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS GLN-346; LYS-493; TYR-622;
RP MET-988; MET-1019 AND MET-1121.
RG NIEHS SNPs program;
RL Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [7]
RP FUNCTION, INVOLVEMENT IN BCNS, VARIANT BCNS GLN-719, AND CHARACTERIZATION
RP OF VARIANT BCNS GLN-719.
RX PubMed=18285427; DOI=10.1136/jmg.2007.055343;
RA Fan Z., Li J., Du J., Zhang H., Shen Y., Wang C.Y., Wang S.;
RT "A missense mutation in PTCH2 underlies dominantly inherited NBCCS in a
RT Chinese family.";
RL J. Med. Genet. 45:303-308(2008).
RN [8]
RP INVOLVEMENT IN BCNS.
RX PubMed=23479190; DOI=10.1007/s10689-013-9623-1;
RA Fujii K., Ohashi H., Suzuki M., Hatsuse H., Shiohama T., Uchikawa H.,
RA Miyashita T.;
RT "Frameshift mutation in the PTCH2 gene can cause nevoid basal cell
RT carcinoma syndrome.";
RL Fam. Cancer 12:611-614(2013).
CC -!- FUNCTION: Plays a role in the control of cellular growth
CC (PubMed:18285427). May have a role in epidermal development. May act as
CC a receptor for Sonic hedgehog (SHH). {ECO:0000269|PubMed:18285427}.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9Y6C5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9Y6C5-2; Sequence=VSP_004542;
CC -!- DISEASE: Medulloblastoma (MDB) [MIM:155255]: Malignant, invasive
CC embryonal tumor of the cerebellum with a preferential manifestation in
CC children. {ECO:0000269|PubMed:9931336}. Note=The disease is caused by
CC variants affecting the gene represented in this entry.
CC -!- DISEASE: Basal cell carcinoma (BCC) [MIM:605462]: A common malignant
CC skin neoplasm that typically appears on hair-bearing skin, most
CC commonly on sun-exposed areas. BCC is slow growing and rarely
CC metastasizes, but has potentialities for local invasion and
CC destruction. It usually develops as a flat, firm, pale area that is
CC small, raised, pink or red, translucent, shiny, and waxy, and the area
CC may bleed following minor injury. Tumor size can vary from a few
CC millimeters to several centimeters in diameter.
CC {ECO:0000269|PubMed:9931336}. Note=The disease is caused by variants
CC affecting the gene represented in this entry.
CC -!- DISEASE: Basal cell nevus syndrome (BCNS) [MIM:109400]: An autosomal
CC dominant disease characterized by nevoid basal cell carcinomas and
CC developmental abnormalities such as rib and craniofacial alterations,
CC polydactyly, syndactyly, and spina bifida. In addition, the patients
CC suffer from a multitude of tumors like basal cell carcinomas, fibromas
CC of the ovaries and heart, cysts of the skin, jaws and mesentery, as
CC well as medulloblastomas and meningiomas. {ECO:0000269|PubMed:18285427,
CC ECO:0000269|PubMed:23479190}. Note=The disease may be caused by
CC variants affecting the gene represented in this entry.
CC -!- SIMILARITY: Belongs to the patched family. {ECO:0000305}.
CC -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and
CC Haematology;
CC URL="http://atlasgeneticsoncology.org/Genes/PTCH2ID41892ch1p34.html";
CC -!- WEB RESOURCE: Name=NIEHS-SNPs;
CC URL="http://egp.gs.washington.edu/data/ptch2/";
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DR EMBL; AF091501; AAC79847.1; -; mRNA.
DR EMBL; AF087651; AAD25953.1; -; mRNA.
DR EMBL; AF119569; AAD17260.1; -; mRNA.
DR EMBL; AY358555; AAQ88919.1; -; mRNA.
DR EMBL; AY359016; AAQ89375.1; -; mRNA.
DR EMBL; AY438664; AAR05447.1; -; Genomic_DNA.
DR EMBL; AL136380; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL592166; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS516.1; -. [Q9Y6C5-1]
DR CCDS; CCDS53312.1; -. [Q9Y6C5-2]
DR RefSeq; NP_001159764.1; NM_001166292.1. [Q9Y6C5-2]
DR RefSeq; NP_003729.3; NM_003738.4. [Q9Y6C5-1]
DR AlphaFoldDB; Q9Y6C5; -.
DR SMR; Q9Y6C5; -.
DR BioGRID; 114195; 18.
DR IntAct; Q9Y6C5; 1.
DR STRING; 9606.ENSP00000361266; -.
DR TCDB; 2.A.6.6.14; the resistance-nodulation-cell division (rnd) superfamily.
DR GlyGen; Q9Y6C5; 2 sites.
DR iPTMnet; Q9Y6C5; -.
DR PhosphoSitePlus; Q9Y6C5; -.
DR BioMuta; PTCH2; -.
DR DMDM; 12643356; -.
DR jPOST; Q9Y6C5; -.
DR PaxDb; Q9Y6C5; -.
DR PeptideAtlas; Q9Y6C5; -.
DR PRIDE; Q9Y6C5; -.
DR Antibodypedia; 18516; 170 antibodies from 28 providers.
DR DNASU; 8643; -.
DR Ensembl; ENST00000372192.4; ENSP00000361266.3; ENSG00000117425.14. [Q9Y6C5-1]
DR Ensembl; ENST00000447098.6; ENSP00000389703.2; ENSG00000117425.14. [Q9Y6C5-2]
DR GeneID; 8643; -.
DR KEGG; hsa:8643; -.
DR MANE-Select; ENST00000372192.4; ENSP00000361266.3; NM_003738.5; NP_003729.3.
DR UCSC; uc010olf.3; human. [Q9Y6C5-1]
DR CTD; 8643; -.
DR DisGeNET; 8643; -.
DR GeneCards; PTCH2; -.
DR HGNC; HGNC:9586; PTCH2.
DR HPA; ENSG00000117425; Group enriched (ovary, parathyroid gland, salivary gland, testis).
DR MalaCards; PTCH2; -.
DR MIM; 109400; phenotype.
DR MIM; 155255; phenotype.
DR MIM; 603673; gene.
DR MIM; 605462; phenotype.
DR neXtProt; NX_Q9Y6C5; -.
DR OpenTargets; ENSG00000117425; -.
DR Orphanet; 377; Gorlin syndrome.
DR Orphanet; 141276; Tessier number 7 facial cleft.
DR PharmGKB; PA33938; -.
DR VEuPathDB; HostDB:ENSG00000117425; -.
DR eggNOG; KOG1935; Eukaryota.
DR GeneTree; ENSGT00940000159901; -.
DR HOGENOM; CLU_002506_0_0_1; -.
DR InParanoid; Q9Y6C5; -.
DR OMA; DFISAQF; -.
DR OrthoDB; 920897at2759; -.
DR PhylomeDB; Q9Y6C5; -.
DR TreeFam; TF106489; -.
DR PathwayCommons; Q9Y6C5; -.
DR Reactome; R-HSA-373080; Class B/2 (Secretin family receptors).
DR SignaLink; Q9Y6C5; -.
DR SIGNOR; Q9Y6C5; -.
DR BioGRID-ORCS; 8643; 13 hits in 1072 CRISPR screens.
DR GenomeRNAi; 8643; -.
DR Pharos; Q9Y6C5; Tbio.
DR PRO; PR:Q9Y6C5; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q9Y6C5; protein.
DR Bgee; ENSG00000117425; Expressed in left testis and 91 other tissues.
DR ExpressionAtlas; Q9Y6C5; baseline and differential.
DR Genevisible; Q9Y6C5; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0097108; F:hedgehog family protein binding; IPI:BHF-UCL.
DR GO; GO:0008158; F:hedgehog receptor activity; IBA:GO_Central.
DR GO; GO:0005119; F:smoothened binding; IPI:BHF-UCL.
DR GO; GO:0001709; P:cell fate determination; IEA:Ensembl.
DR GO; GO:0009957; P:epidermal cell fate specification; IEA:Ensembl.
DR GO; GO:0042633; P:hair cycle; IEA:Ensembl.
DR GO; GO:0045879; P:negative regulation of smoothened signaling pathway; TAS:BHF-UCL.
DR GO; GO:0045606; P:positive regulation of epidermal cell differentiation; IEA:Ensembl.
DR GO; GO:0001558; P:regulation of cell growth; IMP:UniProtKB.
DR GO; GO:0043588; P:skin development; IEA:Ensembl.
DR GO; GO:0007224; P:smoothened signaling pathway; IBA:GO_Central.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR InterPro; IPR004766; TM_rcpt_patched.
DR Pfam; PF02460; Patched; 1.
DR Pfam; PF12349; Sterol-sensing; 1.
DR TIGRFAMs; TIGR00918; 2A060602; 1.
DR PROSITE; PS50156; SSD; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Disease variant; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..1203
FT /note="Protein patched homolog 2"
FT /id="PRO_0000205970"
FT TOPO_DOM 1..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..78
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 79..392
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 393..413
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 414..428
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 429..449
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 450..457
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 458..478
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 479..501
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 502..522
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 523..531
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 532..552
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 553..686
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 687..707
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 708..963
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 964..984
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 985..991
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 992..1012
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1013
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 1014..1034
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1035..1064
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 1065..1085
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1086..1093
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 1094..1114
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1115..1203
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 394..552
FT /note="SSD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00199"
FT REGION 1171..1203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1185..1203
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 370
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 812
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1143..1203
FT /note="WGASSSLPQSFARVTTSMTVAIHPPPLPGAYIHPAPDEPPWSPAATSSGNLS
FT SRGPGPATG -> PEEI (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:10029063"
FT /id="VSP_004542"
FT VARIANT 346
FT /note="E -> Q (in dbSNP:rs11573578)"
FT /evidence="ECO:0000269|Ref.5"
FT /id="VAR_018935"
FT VARIANT 493
FT /note="E -> K (in dbSNP:rs11573581)"
FT /evidence="ECO:0000269|Ref.5"
FT /id="VAR_018936"
FT VARIANT 622
FT /note="H -> Y (in dbSNP:rs11573586)"
FT /evidence="ECO:0000269|Ref.5"
FT /id="VAR_018937"
FT VARIANT 719
FT /note="R -> Q (in BCNS; unknown pathological significance;
FT does not inhibit cell growth when overexpressed in vitro;
FT dbSNP:rs121434397)"
FT /evidence="ECO:0000269|PubMed:18285427"
FT /id="VAR_081391"
FT VARIANT 988
FT /note="T -> M (in dbSNP:rs11573590)"
FT /evidence="ECO:0000269|Ref.5"
FT /id="VAR_018938"
FT VARIANT 995
FT /note="V -> M (in dbSNP:rs11573591)"
FT /id="VAR_050466"
FT VARIANT 1019
FT /note="V -> M (in dbSNP:rs11573591)"
FT /evidence="ECO:0000269|Ref.5"
FT /id="VAR_018939"
FT VARIANT 1121
FT /note="I -> M (in dbSNP:rs11573598)"
FT /evidence="ECO:0000269|Ref.5"
FT /id="VAR_018940"
FT CONFLICT 2
FT /note="T -> N (in Ref. 2; AAD25953)"
FT /evidence="ECO:0000305"
FT CONFLICT 120
FT /note="R -> L (in Ref. 2; AAD25953)"
FT /evidence="ECO:0000305"
FT CONFLICT 175
FT /note="R -> W (in Ref. 1; AAC79847 and 4; AAQ88919/
FT AAQ89375)"
FT /evidence="ECO:0000305"
FT CONFLICT 753
FT /note="Q -> R (in Ref. 2; AAD25953)"
FT /evidence="ECO:0000305"
FT CONFLICT 787
FT /note="N -> S (in Ref. 2; AAD25953)"
FT /evidence="ECO:0000305"
FT CONFLICT 833
FT /note="P -> L (in Ref. 3; AAD17260)"
FT /evidence="ECO:0000305"
FT CONFLICT 837
FT /note="S -> G (in Ref. 2; AAD25953)"
FT /evidence="ECO:0000305"
FT CONFLICT 846
FT /note="D -> E (in Ref. 2; AAD25953)"
FT /evidence="ECO:0000305"
FT CONFLICT 897
FT /note="L -> F (in Ref. 3; AAD17260)"
FT /evidence="ECO:0000305"
FT CONFLICT 1203
FT /note="G -> GDYKDDDDK (in Ref. 4; AAQ88919)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1203 AA; 130544 MW; 4FAB06999782C031 CRC64;
MTRSPPLREL PPSYTPPART AAPQILAGSL KAPLWLRAYF QGLLFSLGCG IQRHCGKVLF
LGLLAFGALA LGLRMAIIET NLEQLWVEVG SRVSQELHYT KEKLGEEAAY TSQMLIQTAR
QEGENILTPE ALGLHLQAAL TASKVQVSLY GKSWDLNKIC YKSGVPLIEN GMIERMIEKL
FPCVILTPLD CFWEGAKLQG GSAYLPGRPD IQWTNLDPEQ LLEELGPFAS LEGFRELLDK
AQVGQAYVGR PCLHPDDLHC PPSAPNHHSR QAPNVAHELS GGCHGFSHKF MHWQEELLLG
GMARDPQGEL LRAEALQSTF LLMSPRQLYE HFRGDYQTHD IGWSEEQAST VLQAWQRRFV
QLAQEALPEN ASQQIHAFSS TTLDDILHAF SEVSAARVVG GYLLMLAYAC VTMLRWDCAQ
SQGSVGLAGV LLVALAVASG LGLCALLGIT FNAATTQVLP FLALGIGVDD VFLLAHAFTE
ALPGTPLQER MGECLQRTGT SVVLTSINNM AAFLMAALVP IPALRAFSLQ AAIVVGCTFV
AVMLVFPAIL SLDLRRRHCQ RLDVLCCFSS PCSAQVIQIL PQELGDGTVP VGIAHLTATV
QAFTHCEASS QHVVTILPPQ AHLVPPPSDP LGSELFSPGG STRDLLGQEE ETRQKAACKS
LPCARWNLAH FARYQFAPLL LQSHAKAIVL VLFGALLGLS LYGATLVQDG LALTDVVPRG
TKEHAFLSAQ LRYFSLYEVA LVTQGGFDYA HSQRALFDLH QRFSSLKAVL PPPATQAPRT
WLHYYRNWLQ GIQAAFDQDW ASGRITRHSY RNGSEDGALA YKLLIQTGDA QEPLDFSQLT
TRKLVDREGL IPPELFYMGL TVWVSSDPLG LAASQANFYP PPPEWLHDKY DTTGENLRIP
PAQPLEFAQF PFLLRGLQKT ADFVEAIEGA RAACAEAGQA GVHAYPSGSP FLFWEQYLGL
RRCFLLAVCI LLVCTFLVCA LLLLNPWTAG LIVLVLAMMT VELFGIMGFL GIKLSAIPVV
ILVASVGIGV EFTVHVALGF LTTQGSRNLR AAHALEHTFA PVTDGAISTL LGLLMLAGSH
FDFIVRYFFA ALTVLTLLGL LHGLVLLPVL LSILGPPPEV IQMYKESPEI LSPPAPQGGG
LRWGASSSLP QSFARVTTSM TVAIHPPPLP GAYIHPAPDE PPWSPAATSS GNLSSRGPGP
ATG
