PTC2_MOUSE
ID PTC2_MOUSE Reviewed; 1182 AA.
AC O35595; A2AE82; Q546T0;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 2.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Protein patched homolog 2;
DE Short=PTC2;
GN Name=Ptch2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Embryo;
RX PubMed=9462734; DOI=10.1038/ng0298-104;
RA Motoyama J., Takabatake T., Takeshima K., Hui C.-C.;
RT "Ptch2, a second mouse Patched gene is co-expressed with Sonic hedgehog.";
RL Nat. Genet. 18:104-106(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/SvJ; TISSUE=Liver;
RX PubMed=12438747; DOI=10.1159/000064064;
RA Froehlich L., Zhanquin L., Beier D.R., Lanske B.;
RT "Genomic structure and refined chromosomal localization of the mouse Ptch2
RT gene.";
RL Cytogenet. Genome Res. 97:106-110(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 196-446.
RC STRAIN=BALB/cJ; TISSUE=Neuroretina;
RX PubMed=9237688; DOI=10.1016/s0014-5793(97)00645-5;
RA Takabatake T., Ogawa M., Takahashi T.C., Mizuno M., Okamoto M.,
RA Takeshima K.;
RT "Hedgehog and patched gene expression in adult ocular tissues.";
RL FEBS Lett. 410:485-489(1997).
CC -!- FUNCTION: Plays a role in the control of cellular growth (By
CC similarity). May have a role in epidermal development. May act as a
CC receptor for Sonic hedgehog (SHH). {ECO:0000250|UniProtKB:Q9Y6C5}.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed in epithelial cells of the developing
CC hair, tooth and whisker.
CC -!- DEVELOPMENTAL STAGE: Detected in 8.5 to 17.5 dpc embryos.
CC -!- SIMILARITY: Belongs to the patched family. {ECO:0000305}.
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DR EMBL; AJ133482; CAC88120.1; -; Genomic_DNA.
DR EMBL; AJ133483; CAC88120.1; JOINED; Genomic_DNA.
DR EMBL; AJ133484; CAC88120.1; JOINED; Genomic_DNA.
DR EMBL; AJ133485; CAC88120.1; JOINED; Genomic_DNA.
DR EMBL; AL671866; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AB010833; BAA24691.1; -; mRNA.
DR CCDS; CCDS18526.1; -.
DR PIR; T13952; T13952.
DR RefSeq; NP_032984.1; NM_008958.3.
DR AlphaFoldDB; O35595; -.
DR SMR; O35595; -.
DR STRING; 10090.ENSMUSP00000030443; -.
DR GlyGen; O35595; 2 sites.
DR iPTMnet; O35595; -.
DR PhosphoSitePlus; O35595; -.
DR PaxDb; O35595; -.
DR PRIDE; O35595; -.
DR ProteomicsDB; 301894; -.
DR Antibodypedia; 18516; 170 antibodies from 28 providers.
DR DNASU; 19207; -.
DR Ensembl; ENSMUST00000030443; ENSMUSP00000030443; ENSMUSG00000028681.
DR GeneID; 19207; -.
DR KEGG; mmu:19207; -.
DR UCSC; uc008uhx.1; mouse.
DR CTD; 8643; -.
DR MGI; MGI:1095405; Ptch2.
DR VEuPathDB; HostDB:ENSMUSG00000028681; -.
DR eggNOG; KOG1935; Eukaryota.
DR GeneTree; ENSGT00940000159901; -.
DR HOGENOM; CLU_002506_0_0_1; -.
DR InParanoid; O35595; -.
DR OMA; DFISAQF; -.
DR OrthoDB; 1190129at2759; -.
DR PhylomeDB; O35595; -.
DR TreeFam; TF106489; -.
DR BioGRID-ORCS; 19207; 2 hits in 72 CRISPR screens.
DR PRO; PR:O35595; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; O35595; protein.
DR Bgee; ENSMUSG00000028681; Expressed in ciliary body and 187 other tissues.
DR ExpressionAtlas; O35595; baseline and differential.
DR Genevisible; O35595; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0097108; F:hedgehog family protein binding; ISO:MGI.
DR GO; GO:0008158; F:hedgehog receptor activity; IBA:GO_Central.
DR GO; GO:0005119; F:smoothened binding; ISO:MGI.
DR GO; GO:0001709; P:cell fate determination; IGI:MGI.
DR GO; GO:0009957; P:epidermal cell fate specification; IGI:MGI.
DR GO; GO:0008544; P:epidermis development; IMP:MGI.
DR GO; GO:0042633; P:hair cycle; IMP:MGI.
DR GO; GO:0045606; P:positive regulation of epidermal cell differentiation; IGI:MGI.
DR GO; GO:0001558; P:regulation of cell growth; ISO:MGI.
DR GO; GO:0043588; P:skin development; IMP:MGI.
DR GO; GO:0007224; P:smoothened signaling pathway; IBA:GO_Central.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR InterPro; IPR004766; TM_rcpt_patched.
DR Pfam; PF02460; Patched; 1.
DR Pfam; PF12349; Sterol-sensing; 1.
DR TIGRFAMs; TIGR00918; 2A060602; 1.
DR PROSITE; PS50156; SSD; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Receptor; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..1182
FT /note="Protein patched homolog 2"
FT /id="PRO_0000205971"
FT TOPO_DOM 1..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..78
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 79..394
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 395..414
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 415..428
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 429..449
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 450..457
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 458..478
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 479..501
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 502..522
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 523..531
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 532..552
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 553..686
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 687..707
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 708..963
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 964..984
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 985..991
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 992..1012
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1013
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 1014..1034
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1035..1064
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 1065..1085
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1086
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 1087..1107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1108..1182
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 394..552
FT /note="SSD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00199"
FT CARBOHYD 370
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 812
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1182 AA; 128586 MW; 715233D912C352F2 CRC64;
MVRPLSLGEL PPSYTPPARS SAPHILAGSL QAPLWLRAYF QGLLFSLGCR IQKHCGKVLF
LGLVAFGALA LGLRVAVIET DLEQLWVEVG SRVSQELHYT KEKLGEEAAY TSQMLIQTAH
QEGGNVLTPE ALDLHLQAAL TASKVQVSLY GKSWDLNKIC YKSGVPLIEN GMIERMIEKL
FPCVILTPLD CFWEGAKLQG GSAYLPGRPD IQWTNLDPQQ LLEELGPFAS LEGFRELLDK
AQVGQAYVGR PCLDPDDPHC PPSAPNRHSR QAPNVAQELS GGCHGFSHKF MHWQEELLLG
GTARDLQGQL LRAEALQSTF LLMSPRQLYE HFRGDYQTHD IGWSEEQASM VLQAWQRRFV
QLAQEALPAN ASQQIHAFSS TTLDDILRAF SEVSTTRVVG GYLLMLAYAC VTMLRWDCAQ
SQGAVGLAGV LLVALAVASG LGLCALLGIT FNAATTQVLP FLALGIGVDD IFLLAHAFTK
APPDTPLPER MGECLRSTGT SVALTSVNNM VAFFMAALVP IPALRAFSLQ AAIVVGCNFA
AVMLVFPAIL SLDLRRRHRQ RLDVLCCFSS PCSAQVIQML PQELGDRAVP VGIAHLTATV
QAFTHCEASS QHVVTILPPQ AHLLSPASDP LGSELYSPGG STRDLLSQEE GTGPQAACRP
LLCAHWTLAH FARYQFAPLL LQTRAKALVL LFFGALLGLS LYGATLVQDG LALTDVVPRG
TKEHAFLSAQ LRYFSLYEVA LVTQGGFDYA HSQRALFDLH QRFSSLKAVL PPPATQAPRT
WLHYYRSWLQ GIQAAFDQDW ASGRITCHSY RNGSEDGALA YKLLIQTGNA QEPLDFSQLT
TRKLVDKEGL IPPELFYMGL TVWVSSDPLG LAASQANFYP PPPEWLHDKY DTTGENLRIP
AAQPLEFAQF PFLLHGLQKT ADFVEAIEGA RAACTEAGQA GVHAYPSGSP FLFWEQYLGL
RRCFLLAVCI LLVCTFLVCA LLLLSPWTAG LIVLVLAMMT VELFGIMGFL GIKLSAIPVV
ILVASIGIGV EFTVHVALGF LTSHGSRNLR AASALEQTFA PVTDGAVSTL LGLLMLAGSN
FDFIIRYFFV VLTVLTLLGL LHGLLLLPVL LSILGPPPQV VQVYKESPQT LNSAAPQRGG
LRWDRPPTLP QSFARVTTSM TVALHPPPLP GAYVHPASEE PT
