PTCA_HUMAN
ID PTCA_HUMAN Reviewed; 206 AA.
AC Q14761; B2R512; O00643; Q6I9S6;
DT 26-JUL-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Protein tyrosine phosphatase receptor type C-associated protein;
DE Short=PTPRC-associated protein;
DE AltName: Full=CD45-associated protein;
DE Short=CD45-AP;
DE AltName: Full=Lymphocyte phosphatase-associated phosphoprotein;
GN Name=PTPRCAP; Synonyms=LPAP;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=7961877; DOI=10.1016/s0021-9258(19)62018-1;
RA Schraven B., Schoenhaut D., Bruyns E., Koretzky G., Eckerskorn C.,
RA Wallich R., Kirchgessner H., Sakorafas P., Labkovsky B., Ratnofsky S.,
RA Meuer S.;
RT "LPAP, a novel 32-kDa phosphoprotein that interacts with CD45 in human
RT lymphocytes.";
RL J. Biol. Chem. 269:29102-29111(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8954783; DOI=10.1006/geno.1996.0595;
RA Bruyns E., Mincheva A., Bruyns R.M., Kirchgessner H., Weitz S., Lichter P.,
RA Meuer S., Schraven B.;
RT "Sequence, genomic organization, and chromosomal localization of the human
RT LPAP (PTPRCAP) and mouse CD45-AP/LSM-1 genes.";
RL Genomics 38:79-83(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Thymus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP INTERACTION WITH CD45.
RX PubMed=8537410; DOI=10.1074/jbc.270.52.31372;
RA Bruyns E., Hendricks-Taylor L.R., Meuer S., Koretzky G.A., Schraven B.;
RT "Identification of the sites of interaction between lymphocyte phosphatase-
RT associated phosphoprotein (LPAP) and CD45.";
RL J. Biol. Chem. 270:31372-31376(1995).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=T-cell;
RX PubMed=19367720; DOI=10.1021/pr800500r;
RA Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J.;
RT "Phosphorylation analysis of primary human T lymphocytes using sequential
RT IMAC and titanium oxide enrichment.";
RL J. Proteome Res. 7:5167-5176(2008).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-99 AND SER-153, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- SUBUNIT: Interacts with CD45/PTPRC. {ECO:0000269|PubMed:8537410}.
CC -!- INTERACTION:
CC Q14761; Q9UHG0: DCDC2; NbExp=3; IntAct=EBI-722217, EBI-10303987;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- PTM: Phosphorylated on tyrosine residues.
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DR EMBL; X81422; CAA57182.1; -; mRNA.
DR EMBL; X97267; CAA65922.1; -; Genomic_DNA.
DR EMBL; CR457429; CAG33710.1; -; mRNA.
DR EMBL; AK312022; BAG34959.1; -; mRNA.
DR EMBL; BC113859; AAI13860.1; -; mRNA.
DR EMBL; BC114467; AAI14468.1; -; mRNA.
DR CCDS; CCDS8163.1; -.
DR PIR; A55412; A55412.
DR RefSeq; NP_005599.1; NM_005608.2.
DR AlphaFoldDB; Q14761; -.
DR BioGRID; 111754; 15.
DR IntAct; Q14761; 5.
DR STRING; 9606.ENSP00000325589; -.
DR BindingDB; Q14761; -.
DR ChEMBL; CHEMBL4806; -.
DR iPTMnet; Q14761; -.
DR PhosphoSitePlus; Q14761; -.
DR BioMuta; PTPRCAP; -.
DR DMDM; 22001841; -.
DR EPD; Q14761; -.
DR jPOST; Q14761; -.
DR MassIVE; Q14761; -.
DR MaxQB; Q14761; -.
DR PaxDb; Q14761; -.
DR PeptideAtlas; Q14761; -.
DR PRIDE; Q14761; -.
DR ProteomicsDB; 60156; -.
DR Antibodypedia; 16508; 118 antibodies from 28 providers.
DR DNASU; 5790; -.
DR Ensembl; ENST00000326294.4; ENSP00000325589.3; ENSG00000213402.3.
DR GeneID; 5790; -.
DR KEGG; hsa:5790; -.
DR MANE-Select; ENST00000326294.4; ENSP00000325589.3; NM_005608.3; NP_005599.1.
DR UCSC; uc001oli.2; human.
DR CTD; 5790; -.
DR DisGeNET; 5790; -.
DR GeneCards; PTPRCAP; -.
DR HGNC; HGNC:9667; PTPRCAP.
DR HPA; ENSG00000213402; Group enriched (intestine, lymphoid tissue).
DR MIM; 601577; gene.
DR neXtProt; NX_Q14761; -.
DR OpenTargets; ENSG00000213402; -.
DR PharmGKB; PA34012; -.
DR VEuPathDB; HostDB:ENSG00000213402; -.
DR eggNOG; ENOG502SG9X; Eukaryota.
DR GeneTree; ENSGT00390000017041; -.
DR HOGENOM; CLU_1444125_0_0_1; -.
DR InParanoid; Q14761; -.
DR OMA; PGHWLQT; -.
DR OrthoDB; 1207721at2759; -.
DR PhylomeDB; Q14761; -.
DR TreeFam; TF338317; -.
DR PathwayCommons; Q14761; -.
DR SignaLink; Q14761; -.
DR BioGRID-ORCS; 5790; 21 hits in 1077 CRISPR screens.
DR GeneWiki; PTPRCAP; -.
DR GenomeRNAi; 5790; -.
DR Pharos; Q14761; Tbio.
DR PRO; PR:Q14761; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q14761; protein.
DR Bgee; ENSG00000213402; Expressed in granulocyte and 90 other tissues.
DR Genevisible; Q14761; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:MGI.
DR GO; GO:0006952; P:defense response; TAS:ProtInc.
DR InterPro; IPR016553; PTPRCAP.
DR PANTHER; PTHR15312; PTHR15312; 1.
DR Pfam; PF15713; PTPRCAP; 1.
DR PIRSF; PIRSF009325; PTPRC-associated_protein; 1.
PE 1: Evidence at protein level;
KW Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..206
FT /note="Protein tyrosine phosphatase receptor type C-
FT associated protein"
FT /id="PRO_0000097087"
FT TRANSMEM 34..54
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 98..173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 99
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 153
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT VARIANT 128
FT /note="G -> E (in dbSNP:rs60969594)"
FT /id="VAR_061698"
SQ SEQUENCE 206 AA; 21196 MW; 26A9F96699BD34D5 CRC64;
MALPCTLGLG MLLALPGALG SGGSAEDSVG SSSVTVVLLL LLLLLLATGL ALAWRRLSRD
SGGYYHPARL GAALWGRTRR LLWASPPGRW LQARAELGST DNDLERQEDE QDTDYDHVAD
GGLQADPGEG EQQCGEASSP EQVPVRAEEA RDSDTEGDLV LGSPGPASAG GSAEALLSDL
HAFAGSAAWD DSARAAGGQG LHVTAL
