PTCA_MOUSE
ID PTCA_MOUSE Reviewed; 197 AA.
AC Q64697;
DT 26-JUL-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Protein tyrosine phosphatase receptor type C-associated protein;
DE Short=PTPRC-associated protein;
DE AltName: Full=CD45-associated protein;
DE Short=CD45-AP;
DE AltName: Full=LSM-1;
GN Name=Ptprcap;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ; TISSUE=Lymphoid tissue;
RX PubMed=7957956; DOI=10.1016/0014-5793(94)01164-8;
RA Shimizu Y., Ogawa H., Oka Y., Mizuno R., Sakoda S., Kishimoto T.,
RA Sugiyama H.;
RT "Isolation of a cDNA clone encoding a novel membrane protein expressed in
RT lymphocytes.";
RL FEBS Lett. 355:30-34(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ; TISSUE=Blood;
RX PubMed=8300558; DOI=10.1016/s0021-9258(17)41950-8;
RA Takeda A., Maizel A.L., Kitamura K., Ohta T., Kimura S.;
RT "Molecular cloning of the CD45-associated 30-kDa protein.";
RL J. Biol. Chem. 269:2357-2360(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-99 AND SER-103, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Lung, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBUNIT: Interacts with CD45/PTPRC.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Leukocyte-specific. Expressed in B- and T-cell
CC lines, in spleen, thymus, and bone marrow of adult mice, and in
CC embryos.
CC -!- PTM: Phosphorylated on tyrosine residues.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA67166.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; D10105; BAA00986.1; -; mRNA.
DR EMBL; U03856; AAA67166.1; ALT_INIT; mRNA.
DR EMBL; BC013273; AAH13273.1; -; mRNA.
DR CCDS; CCDS37884.1; -.
DR PIR; S51372; S51372.
DR RefSeq; NP_058629.2; NM_016933.3.
DR AlphaFoldDB; Q64697; -.
DR IntAct; Q64697; 5.
DR STRING; 10090.ENSMUSP00000053412; -.
DR iPTMnet; Q64697; -.
DR PhosphoSitePlus; Q64697; -.
DR SwissPalm; Q64697; -.
DR EPD; Q64697; -.
DR MaxQB; Q64697; -.
DR PaxDb; Q64697; -.
DR PRIDE; Q64697; -.
DR ProteomicsDB; 291583; -.
DR Antibodypedia; 16508; 118 antibodies from 28 providers.
DR DNASU; 19265; -.
DR Ensembl; ENSMUST00000061086; ENSMUSP00000053412; ENSMUSG00000045826.
DR GeneID; 19265; -.
DR KEGG; mmu:19265; -.
DR UCSC; uc008fza.1; mouse.
DR CTD; 5790; -.
DR MGI; MGI:97811; Ptprcap.
DR VEuPathDB; HostDB:ENSMUSG00000045826; -.
DR eggNOG; ENOG502SG9X; Eukaryota.
DR GeneTree; ENSGT00390000017041; -.
DR HOGENOM; CLU_1444125_0_0_1; -.
DR InParanoid; Q64697; -.
DR OMA; PGHWLQT; -.
DR OrthoDB; 1497325at2759; -.
DR PhylomeDB; Q64697; -.
DR TreeFam; TF338317; -.
DR BioGRID-ORCS; 19265; 3 hits in 70 CRISPR screens.
DR ChiTaRS; Ptprcap; mouse.
DR PRO; PR:Q64697; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q64697; protein.
DR Bgee; ENSMUSG00000045826; Expressed in thymus and 57 other tissues.
DR ExpressionAtlas; Q64697; baseline and differential.
DR Genevisible; Q64697; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR InterPro; IPR016553; PTPRCAP.
DR PANTHER; PTHR15312; PTHR15312; 1.
DR Pfam; PF15713; PTPRCAP; 1.
DR PIRSF; PIRSF009325; PTPRC-associated_protein; 1.
PE 1: Evidence at protein level;
KW Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..197
FT /note="Protein tyrosine phosphatase receptor type C-
FT associated protein"
FT /id="PRO_0000097088"
FT TRANSMEM 33..53
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 120..164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 177..197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..146
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 148..162
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 99
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 103
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CONFLICT 55
FT /note="R -> C (in Ref. 2; AAA67166)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 197 AA; 20371 MW; B313F88693F084AA CRC64;
MALPGTLRFG VLMALPGALA SGADPEDGVG SSVVTIVLLL LLLLLLVTAL ALAWRRLSHA
SGGYYHPARL GAALWGHTCR LLWASPAGRW LRARTELESP EESGPPEDEE DAEDFVIDGG
PEEAAAKEEE QRCQAEQTRD PRDTDSDGGL GLSSQGPVGS GSSAEALLSD LHAFSGSAAW
DDSAGGAGGQ GLRVTAL
