PTCD1_MOUSE
ID PTCD1_MOUSE Reviewed; 695 AA.
AC Q8C2E4; Q3TB29; Q5XK29; Q99KB2;
DT 12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Pentatricopeptide repeat-containing protein 1, mitochondrial;
GN Name=Ptcd1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and FVB/N; TISSUE=Embryonic germ cell, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Mitochondrial protein implicated in negative regulation of
CC leucine tRNA levels, as well as negative regulation of mitochondria-
CC encoded proteins and COX activity. Affects also the 3'-processing of
CC mitochondrial tRNAs. {ECO:0000250}.
CC -!- SUBUNIT: Associates with mitochondrial leucine tRNAs. Interacts with
CC ELAC2. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}. Mitochondrion matrix
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the PTCD1 family. {ECO:0000305}.
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DR EMBL; AK088764; BAC40555.1; -; mRNA.
DR EMBL; AK171484; BAE42485.1; -; mRNA.
DR EMBL; BC004766; AAH04766.2; -; mRNA.
DR EMBL; BC083097; AAH83097.1; -; mRNA.
DR CCDS; CCDS19858.1; -.
DR RefSeq; NP_598496.3; NM_133735.2.
DR AlphaFoldDB; Q8C2E4; -.
DR SMR; Q8C2E4; -.
DR BioGRID; 214937; 3.
DR STRING; 10090.ENSMUSP00000031628; -.
DR PhosphoSitePlus; Q8C2E4; -.
DR EPD; Q8C2E4; -.
DR MaxQB; Q8C2E4; -.
DR PaxDb; Q8C2E4; -.
DR PRIDE; Q8C2E4; -.
DR ProteomicsDB; 302003; -.
DR DNASU; 71799; -.
DR Ensembl; ENSMUST00000031628; ENSMUSP00000031628; ENSMUSG00000029624.
DR GeneID; 71799; -.
DR KEGG; mmu:71799; -.
DR UCSC; uc009amh.2; mouse.
DR CTD; 26024; -.
DR MGI; MGI:1919049; Ptcd1.
DR VEuPathDB; HostDB:ENSMUSG00000029624; -.
DR eggNOG; KOG4197; Eukaryota.
DR GeneTree; ENSGT00940000153974; -.
DR HOGENOM; CLU_021952_0_0_1; -.
DR InParanoid; Q8C2E4; -.
DR OMA; YTYLINI; -.
DR OrthoDB; 1344243at2759; -.
DR PhylomeDB; Q8C2E4; -.
DR TreeFam; TF324792; -.
DR BioGRID-ORCS; 71799; 17 hits in 74 CRISPR screens.
DR ChiTaRS; Ptcd1; mouse.
DR PRO; PR:Q8C2E4; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q8C2E4; protein.
DR Bgee; ENSMUSG00000029624; Expressed in floor plate of midbrain and 240 other tissues.
DR ExpressionAtlas; Q8C2E4; baseline and differential.
DR Genevisible; Q8C2E4; MM.
DR GO; GO:0005759; C:mitochondrial matrix; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; ISO:MGI.
DR GO; GO:0000049; F:tRNA binding; ISS:UniProtKB.
DR GO; GO:0032543; P:mitochondrial translation; IMP:CACAO.
DR GO; GO:0042780; P:tRNA 3'-end processing; ISS:UniProtKB.
DR Gene3D; 1.25.40.10; -; 3.
DR InterPro; IPR002885; Pentatricopeptide_repeat.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR Pfam; PF13041; PPR_2; 1.
DR Pfam; PF13812; PPR_3; 2.
DR TIGRFAMs; TIGR00756; PPR; 1.
DR PROSITE; PS51375; PPR; 7.
PE 2: Evidence at transcript level;
KW Mitochondrion; Reference proteome; Repeat; tRNA processing.
FT CHAIN 1..695
FT /note="Pentatricopeptide repeat-containing protein 1,
FT mitochondrial"
FT /id="PRO_0000097090"
FT REPEAT 133..169
FT /note="PPR 1"
FT REPEAT 170..204
FT /note="PPR 2"
FT REPEAT 205..243
FT /note="PPR 3"
FT REPEAT 244..278
FT /note="PPR 4"
FT REPEAT 279..315
FT /note="PPR 5"
FT REPEAT 316..352
FT /note="PPR 6"
FT REPEAT 470..485
FT /note="PPR 5"
FT REPEAT 517..551
FT /note="PPR 7"
FT REPEAT 552..583
FT /note="PPR 8"
FT REPEAT 584..618
FT /note="PPR 9"
FT REGION 391..416
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 672..695
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 16
FT /note="I -> L (in Ref. 1; BAC40555 and 2; AAH04766)"
FT /evidence="ECO:0000305"
FT CONFLICT 40
FT /note="A -> E (in Ref. 1; BAC40555 and 2; AAH04766)"
FT /evidence="ECO:0000305"
FT CONFLICT 349
FT /note="T -> N (in Ref. 1; BAC40555 and 2; AAH04766)"
FT /evidence="ECO:0000305"
FT CONFLICT 429
FT /note="S -> P (in Ref. 1; BAC40555 and 2; AAH04766)"
FT /evidence="ECO:0000305"
FT CONFLICT 500
FT /note="T -> A (in Ref. 1; BAC40555 and 2; AAH04766)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 695 AA; 77594 MW; 3E88AD137249538A CRC64;
MDLLRLSRLF SGPRPIGLSV LQHLDLVGST RWTGGREGPA RLRAAFCGSS SPLPLGSGNQ
KEMSSLCSDS SKLSTVAPQE EAEEESFGSL SGKFSSRRIF HKSTAQLYNL QLKEQGGEEE
ELEPRPWRGR RNTQYWYFFQ CKRLIKEGKL AEALDLFERQ MLKEERLQPL ECNYTVLIGG
CGRVGYLKKA FRLFNDMKKR DLEPSDATYT ALFNVCAESP WKDSALQSAL KLRQQLQARN
FQLNLKTYHA LLKVAAKCAD LRLCLDVFKE IIQRGHAVTE ETFCFLLVGC IQDKKTGFRQ
AMQVWRQMLS LGIKPSRHGY NLLLEAARDC GLGDPEVASR LLLTSQEETI LLPPPKGRHM
AGRKVQAKTV HGVSLRHVEA LERQLFLEPS QKLEGPPALP EARVTSRTQP EVETTAEPGH
TVALTPLASK PTHLELEVSL LSLGTLSPAV VSFGTVATPA DRLALMGGLE GFLGKMTEHG
LQPDIKTLTL LAEVVEPGST AESSLLSVLD RHRVEADVTF FNTLIRKKSK LGDLEGAKAL
LPILAKKGIV PNLRTFCNLA IGCHRPRDGM QLLADMKKSQ VSPNIHIYST LINAALKKLD
YTYLISILKD MRQNSVPVNE VVVRQLEFAA EYPPTFDRYK GKNTYLEKID GFRAYYKQWL
KAMPAEEAPH PWQEFQNKPV GDQDTTDKAG GLRDG
