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PTCD1_PONAB
ID   PTCD1_PONAB             Reviewed;         698 AA.
AC   Q5R655;
DT   29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Pentatricopeptide repeat-containing protein 1, mitochondrial;
GN   Name=PTCD1;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mitochondrial protein implicated in negative regulation of
CC       leucine tRNA levels, as well as negative regulation of mitochondria-
CC       encoded proteins and COX activity. Affects also the 3'-processing of
CC       mitochondrial tRNAs. {ECO:0000250}.
CC   -!- SUBUNIT: Associates with mitochondrial leucine tRNAs. Interacts with
CC       ELAC2. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}. Mitochondrion matrix
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PTCD1 family. {ECO:0000305}.
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DR   EMBL; CR860641; CAH92761.1; -; mRNA.
DR   RefSeq; NP_001127583.1; NM_001134111.1.
DR   AlphaFoldDB; Q5R655; -.
DR   SMR; Q5R655; -.
DR   STRING; 9601.ENSPPYP00000019470; -.
DR   PRIDE; Q5R655; -.
DR   GeneID; 100174661; -.
DR   KEGG; pon:100174661; -.
DR   CTD; 26024; -.
DR   eggNOG; KOG4197; Eukaryota.
DR   InParanoid; Q5R655; -.
DR   OrthoDB; 1344243at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005759; C:mitochondrial matrix; ISS:UniProtKB.
DR   GO; GO:0000049; F:tRNA binding; ISS:UniProtKB.
DR   GO; GO:0042780; P:tRNA 3'-end processing; ISS:UniProtKB.
DR   Gene3D; 1.25.40.10; -; 3.
DR   InterPro; IPR002885; Pentatricopeptide_repeat.
DR   InterPro; IPR033443; PPR_long.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   Pfam; PF13812; PPR_3; 1.
DR   Pfam; PF17177; PPR_long; 1.
DR   TIGRFAMs; TIGR00756; PPR; 1.
DR   PROSITE; PS51375; PPR; 7.
PE   2: Evidence at transcript level;
KW   Mitochondrion; Reference proteome; Repeat; tRNA processing.
FT   CHAIN           1..698
FT                   /note="Pentatricopeptide repeat-containing protein 1,
FT                   mitochondrial"
FT                   /id="PRO_0000097091"
FT   REPEAT          133..169
FT                   /note="PPR 1"
FT   REPEAT          170..204
FT                   /note="PPR 2"
FT   REPEAT          205..243
FT                   /note="PPR 3"
FT   REPEAT          244..278
FT                   /note="PPR 4"
FT   REPEAT          279..315
FT                   /note="PPR 5"
FT   REPEAT          316..352
FT                   /note="PPR 6"
FT   REPEAT          517..551
FT                   /note="PPR 7"
FT   REPEAT          552..583
FT                   /note="PPR 8"
FT   REPEAT          584..618
FT                   /note="PPR 9"
FT   REGION          49..88
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          392..419
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          670..698
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        49..75
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        671..698
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   698 AA;  78658 MW;  72AD493C89AB9954 CRC64;
     MDFVRLARLF SRARPMGLFI LQHLDPCRAR WAGGREGLMR PVWAPFGSSS SQLPLGQERQ
     ENTGSLGSDP SHSNSTATQE EDEEESFGAL SDKYSSRRLF RKSTAQFHNL RFGERRDEQT
     KPEPKLWRGQ RNTPYWYFLQ CKRLIKEGKL VEALDLFERQ MLKEERLQPM ESNYTALIGG
     CGRVGYLKKA FSLYNQMKKR DLEPSDATYT ALFNVCAESP WKDSALQSAL KLRQQLQAKN
     FELNLKTYHA LLKMAAKCAD LRMCLDVFKE IIHKGHVVTE ETFSFLLMGC IQDKKTGFRY
     ALQVWRLMLS LGLQPSRDSY NLLLVAARDC GLGDPQVASE LLLKPREEAT VLQPPVSRQQ
     PRRTAQAKAG NLMSAMLHVE ALERQLFLET SQALGPPEPP EARVPSKAQP EVDTKAEPSH
     TAALTPVALK PPPLELEVNL LTPGAVPPTV VSFGTVTTPA DRLALVGGLE GFLSKMAEHR
     QQPDIRTLTL LAEVVESGSP AESLLLALLD EHQVEADLTF FNTLVRKKSK LGDLEGAKAL
     LPVLAKRGLV PNLQTFCNLA IGCHRPKDGL QLLTDMKKSQ VTPNSHIYSA LINAAVRKLN
     YTYLINILKD MKQNRVPVNE VVIRQLEFAA QYPPTFDRYQ GKNTYLEKID GFRAYYKQWL
     TVMPAEETPH PWQKFRTKPQ EDQDTRKEAD DGCALGGR
 
 
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