PTCD1_PONAB
ID PTCD1_PONAB Reviewed; 698 AA.
AC Q5R655;
DT 29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 25-MAY-2022, entry version 58.
DE RecName: Full=Pentatricopeptide repeat-containing protein 1, mitochondrial;
GN Name=PTCD1;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain cortex;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mitochondrial protein implicated in negative regulation of
CC leucine tRNA levels, as well as negative regulation of mitochondria-
CC encoded proteins and COX activity. Affects also the 3'-processing of
CC mitochondrial tRNAs. {ECO:0000250}.
CC -!- SUBUNIT: Associates with mitochondrial leucine tRNAs. Interacts with
CC ELAC2. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}. Mitochondrion matrix
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the PTCD1 family. {ECO:0000305}.
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DR EMBL; CR860641; CAH92761.1; -; mRNA.
DR RefSeq; NP_001127583.1; NM_001134111.1.
DR AlphaFoldDB; Q5R655; -.
DR SMR; Q5R655; -.
DR STRING; 9601.ENSPPYP00000019470; -.
DR PRIDE; Q5R655; -.
DR GeneID; 100174661; -.
DR KEGG; pon:100174661; -.
DR CTD; 26024; -.
DR eggNOG; KOG4197; Eukaryota.
DR InParanoid; Q5R655; -.
DR OrthoDB; 1344243at2759; -.
DR Proteomes; UP000001595; Unplaced.
DR GO; GO:0005759; C:mitochondrial matrix; ISS:UniProtKB.
DR GO; GO:0000049; F:tRNA binding; ISS:UniProtKB.
DR GO; GO:0042780; P:tRNA 3'-end processing; ISS:UniProtKB.
DR Gene3D; 1.25.40.10; -; 3.
DR InterPro; IPR002885; Pentatricopeptide_repeat.
DR InterPro; IPR033443; PPR_long.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR Pfam; PF13812; PPR_3; 1.
DR Pfam; PF17177; PPR_long; 1.
DR TIGRFAMs; TIGR00756; PPR; 1.
DR PROSITE; PS51375; PPR; 7.
PE 2: Evidence at transcript level;
KW Mitochondrion; Reference proteome; Repeat; tRNA processing.
FT CHAIN 1..698
FT /note="Pentatricopeptide repeat-containing protein 1,
FT mitochondrial"
FT /id="PRO_0000097091"
FT REPEAT 133..169
FT /note="PPR 1"
FT REPEAT 170..204
FT /note="PPR 2"
FT REPEAT 205..243
FT /note="PPR 3"
FT REPEAT 244..278
FT /note="PPR 4"
FT REPEAT 279..315
FT /note="PPR 5"
FT REPEAT 316..352
FT /note="PPR 6"
FT REPEAT 517..551
FT /note="PPR 7"
FT REPEAT 552..583
FT /note="PPR 8"
FT REPEAT 584..618
FT /note="PPR 9"
FT REGION 49..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 392..419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 670..698
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..75
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 671..698
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 698 AA; 78658 MW; 72AD493C89AB9954 CRC64;
MDFVRLARLF SRARPMGLFI LQHLDPCRAR WAGGREGLMR PVWAPFGSSS SQLPLGQERQ
ENTGSLGSDP SHSNSTATQE EDEEESFGAL SDKYSSRRLF RKSTAQFHNL RFGERRDEQT
KPEPKLWRGQ RNTPYWYFLQ CKRLIKEGKL VEALDLFERQ MLKEERLQPM ESNYTALIGG
CGRVGYLKKA FSLYNQMKKR DLEPSDATYT ALFNVCAESP WKDSALQSAL KLRQQLQAKN
FELNLKTYHA LLKMAAKCAD LRMCLDVFKE IIHKGHVVTE ETFSFLLMGC IQDKKTGFRY
ALQVWRLMLS LGLQPSRDSY NLLLVAARDC GLGDPQVASE LLLKPREEAT VLQPPVSRQQ
PRRTAQAKAG NLMSAMLHVE ALERQLFLET SQALGPPEPP EARVPSKAQP EVDTKAEPSH
TAALTPVALK PPPLELEVNL LTPGAVPPTV VSFGTVTTPA DRLALVGGLE GFLSKMAEHR
QQPDIRTLTL LAEVVESGSP AESLLLALLD EHQVEADLTF FNTLVRKKSK LGDLEGAKAL
LPVLAKRGLV PNLQTFCNLA IGCHRPKDGL QLLTDMKKSQ VTPNSHIYSA LINAAVRKLN
YTYLINILKD MKQNRVPVNE VVIRQLEFAA QYPPTFDRYQ GKNTYLEKID GFRAYYKQWL
TVMPAEETPH PWQKFRTKPQ EDQDTRKEAD DGCALGGR