PTCD1_RAT
ID PTCD1_RAT Reviewed; 686 AA.
AC A2VD13;
DT 31-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT 20-MAR-2007, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Pentatricopeptide repeat-containing protein 1, mitochondrial;
GN Name=Ptcd1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP SUBCELLULAR LOCATION.
RX PubMed=19651879; DOI=10.1093/nar/gkp627;
RA Rackham O., Davies S.M., Shearwood A.M., Hamilton K.L., Whelan J.,
RA Filipovska A.;
RT "Pentatricopeptide repeat domain protein 1 lowers the levels of
RT mitochondrial leucine tRNAs in cells.";
RL Nucleic Acids Res. 37:5859-5867(2009).
CC -!- FUNCTION: Mitochondrial protein implicated in negative regulation of
CC leucine tRNA levels, as well as negative regulation of mitochondria-
CC encoded proteins and COX activity. Affects also the 3'-processing of
CC mitochondrial tRNAs. {ECO:0000250}.
CC -!- SUBUNIT: Associates with mitochondrial leucine tRNAs. Interacts with
CC ELAC2. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion matrix
CC {ECO:0000269|PubMed:19651879}.
CC -!- SIMILARITY: Belongs to the PTCD1 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AABR06070420; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC129116; AAI29117.1; -; mRNA.
DR RefSeq; XP_006248933.1; XM_006248871.1.
DR AlphaFoldDB; A2VD13; -.
DR SMR; A2VD13; -.
DR STRING; 10116.ENSRNOP00000068093; -.
DR PaxDb; A2VD13; -.
DR PeptideAtlas; A2VD13; -.
DR PRIDE; A2VD13; -.
DR Ensembl; ENSRNOT00000076896; ENSRNOP00000068093; ENSRNOG00000000987.
DR GeneID; 304278; -.
DR CTD; 26024; -.
DR RGD; 1311473; Ptcd1.
DR eggNOG; KOG4197; Eukaryota.
DR GeneTree; ENSGT00940000153974; -.
DR HOGENOM; CLU_021952_0_0_1; -.
DR InParanoid; A2VD13; -.
DR OMA; YTYLINI; -.
DR OrthoDB; 1344243at2759; -.
DR TreeFam; TF324792; -.
DR PRO; PR:A2VD13; -.
DR Proteomes; UP000002494; Chromosome 12.
DR Bgee; ENSRNOG00000000987; Expressed in pancreas and 20 other tissues.
DR ExpressionAtlas; A2VD13; baseline and differential.
DR Genevisible; A2VD13; RN.
DR GO; GO:0005759; C:mitochondrial matrix; IDA:UniProtKB.
DR GO; GO:0000049; F:tRNA binding; ISS:UniProtKB.
DR GO; GO:0032543; P:mitochondrial translation; ISO:RGD.
DR GO; GO:0042780; P:tRNA 3'-end processing; ISS:UniProtKB.
DR Gene3D; 1.25.40.10; -; 3.
DR InterPro; IPR002885; Pentatricopeptide_repeat.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR Pfam; PF13041; PPR_2; 1.
DR Pfam; PF13812; PPR_3; 1.
DR TIGRFAMs; TIGR00756; PPR; 1.
DR PROSITE; PS51375; PPR; 7.
PE 2: Evidence at transcript level;
KW Mitochondrion; Reference proteome; Repeat; tRNA processing.
FT CHAIN 1..686
FT /note="Pentatricopeptide repeat-containing protein 1,
FT mitochondrial"
FT /id="PRO_0000420158"
FT REPEAT 124..160
FT /note="PPR 1"
FT REPEAT 161..195
FT /note="PPR 2"
FT REPEAT 196..234
FT /note="PPR 3"
FT REPEAT 235..269
FT /note="PPR 4"
FT REPEAT 270..306
FT /note="PPR 5"
FT REPEAT 508..542
FT /note="PPR 6"
FT REPEAT 575..609
FT /note="PPR 7"
FT REGION 55..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 383..407
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 686 AA; 77121 MW; 626472E097FBCA11 CRC64;
MDLLRLSRLF SGPHPIGLSV LQRLDLLRST QWTGGREGPA WLRAASCSSS SHQKRMSSLC
SDSSTPVAPQ EEEEEESFGT LSEKFSSRRI FHKSTAQLYN LKLKEQGVEE EELEPRLRQG
GRNTPYWYFL QCKRLLKEGK LAEALDLFER QMLKEERLQP LECNYTVLIG GCGRVGYLKK
AFRLFNDMKK RDLEPSDATY TALFNVCAES PWKDSALQSA LKLRQQLQAQ NFQLNLKTYH
ALLKVAAKCA DLRVCLEVFK EIIQKGHAVT EETFCFLLMG CIQDKKTGFR QAMQVWRQML
SLGIKPSRHG YNLLLGAARD CGLGDPEVAS RLLLTSQEET ILLQPPTGRR LAGGKVQAKT
RHGVSVKHVE ALERQLFLEP SHKLEGPPAF PEARETSRTQ PEVETKAEPG HMGALAPLAL
KPPDLELQVN LLSLGALSPA VVSFGTVATP ADRLALMGGL EGFLGKMAEH RLQPDIKTLT
LLAEVVEPGS PAESSLLSIL DRHRVEADIT FFNTLIRKKS KLGDLEGAKA LLPILAKKGI
VPNLRTFCNL AIGCHRPRDG MQLLADMKKS QVTPNTHIYS TLINAALKKL DYTYLISILK
DMRRNSVPVN EVVIRQLEFA AQYPPTFDRY KEKNTYLEKI DGFRAYYKQW LKVMPAEEPP
HPWQEFRDKP VRNQVITENA GGLRDG
