PTCD3_BOVIN
ID PTCD3_BOVIN Reviewed; 688 AA.
AC Q2KI62;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 07-MAR-2006, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Pentatricopeptide repeat domain-containing protein 3, mitochondrial;
DE AltName: Full=28S ribosomal protein S39, mitochondrial;
DE Short=MRP-S39;
DE Flags: Precursor;
GN Name=PTCD3; Synonyms=MRPS39;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Heart ventricle;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mitochondrial RNA-binding protein that has a role in
CC mitochondrial translation. {ECO:0000250}.
CC -!- SUBUNIT: Component of the mitochondrial ribosome small subunit (28S)
CC which comprises a 12S rRNA and about 30 distinct proteins. Associated
CC with the 12S mitochondrial rRNA (12S mt-rRNA) (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the mitochondrion-specific ribosomal protein
CC mS39 family. {ECO:0000305}.
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DR EMBL; BC112757; AAI12758.1; -; mRNA.
DR RefSeq; NP_001039499.1; NM_001046034.1.
DR PDB; 3JD5; EM; 7.00 A; o=1-688.
DR PDB; 6NEQ; EM; 3.32 A; o=1-688.
DR PDB; 6NF8; EM; 3.48 A; o=1-688.
DR PDBsum; 3JD5; -.
DR PDBsum; 6NEQ; -.
DR PDBsum; 6NF8; -.
DR AlphaFoldDB; Q2KI62; -.
DR SMR; Q2KI62; -.
DR IntAct; Q2KI62; 29.
DR STRING; 9913.ENSBTAP00000008498; -.
DR PaxDb; Q2KI62; -.
DR PRIDE; Q2KI62; -.
DR Ensembl; ENSBTAT00000008498; ENSBTAP00000008498; ENSBTAG00000006482.
DR GeneID; 509502; -.
DR KEGG; bta:509502; -.
DR CTD; 55037; -.
DR VEuPathDB; HostDB:ENSBTAG00000006482; -.
DR VGNC; VGNC:33491; PTCD3.
DR eggNOG; KOG4422; Eukaryota.
DR GeneTree; ENSGT00390000016876; -.
DR HOGENOM; CLU_026264_0_1_1; -.
DR InParanoid; Q2KI62; -.
DR OMA; FMHQEAQ; -.
DR OrthoDB; 405419at2759; -.
DR TreeFam; TF320158; -.
DR Proteomes; UP000009136; Chromosome 11.
DR Bgee; ENSBTAG00000006482; Expressed in infraspinatus muscle and 107 other tissues.
DR ExpressionAtlas; Q2KI62; baseline and differential.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
DR GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW.
DR GO; GO:0043024; F:ribosomal small subunit binding; ISS:UniProtKB.
DR GO; GO:0019843; F:rRNA binding; ISS:UniProtKB.
DR GO; GO:0032543; P:mitochondrial translation; ISS:UniProtKB.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.10; -; 2.
DR InterPro; IPR002885; Pentatricopeptide_repeat.
DR InterPro; IPR037387; PTCD3.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR16276; PTHR16276; 1.
DR Pfam; PF13041; PPR_2; 1.
DR Pfam; PF13812; PPR_3; 1.
DR PROSITE; PS51375; PPR; 4.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Mitochondrion; Reference proteome; Repeat;
KW Ribonucleoprotein; Ribosomal protein; RNA-binding; rRNA-binding;
KW Transit peptide; Translation regulation.
FT TRANSIT 1..37
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 38..688
FT /note="Pentatricopeptide repeat domain-containing protein
FT 3, mitochondrial"
FT /id="PRO_0000305027"
FT REPEAT 149..183
FT /note="PPR 1"
FT REPEAT 184..219
FT /note="PPR 2"
FT REPEAT 258..292
FT /note="PPR 3"
FT REPEAT 293..333
FT /note="PPR 4"
FT REPEAT 334..370
FT /note="PPR 5"
FT REPEAT 371..412
FT /note="PPR 6"
FT REPEAT 415..449
FT /note="PPR 7"
FT REPEAT 457..491
FT /note="PPR 8"
FT REPEAT 492..526
FT /note="PPR 9"
FT REPEAT 575..609
FT /note="PPR 10"
FT REGION 667..688
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 126
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q96EY7"
FT HELIX 70..77
FT /evidence="ECO:0007829|PDB:6NEQ"
FT STRAND 87..89
FT /evidence="ECO:0007829|PDB:6NEQ"
FT TURN 93..95
FT /evidence="ECO:0007829|PDB:6NF8"
FT HELIX 100..122
FT /evidence="ECO:0007829|PDB:6NEQ"
FT HELIX 125..128
FT /evidence="ECO:0007829|PDB:6NEQ"
FT STRAND 137..141
FT /evidence="ECO:0007829|PDB:6NEQ"
FT HELIX 145..154
FT /evidence="ECO:0007829|PDB:6NEQ"
FT HELIX 157..167
FT /evidence="ECO:0007829|PDB:6NEQ"
FT HELIX 171..180
FT /evidence="ECO:0007829|PDB:6NEQ"
FT HELIX 184..188
FT /evidence="ECO:0007829|PDB:6NEQ"
FT HELIX 283..288
FT /evidence="ECO:0007829|PDB:6NEQ"
FT HELIX 291..303
FT /evidence="ECO:0007829|PDB:6NEQ"
FT HELIX 306..317
FT /evidence="ECO:0007829|PDB:6NEQ"
FT HELIX 320..327
FT /evidence="ECO:0007829|PDB:6NEQ"
FT HELIX 336..344
FT /evidence="ECO:0007829|PDB:6NEQ"
FT HELIX 348..355
FT /evidence="ECO:0007829|PDB:6NEQ"
FT TURN 356..358
FT /evidence="ECO:0007829|PDB:6NEQ"
FT HELIX 362..369
FT /evidence="ECO:0007829|PDB:6NEQ"
FT TURN 372..375
FT /evidence="ECO:0007829|PDB:6NEQ"
FT HELIX 376..382
FT /evidence="ECO:0007829|PDB:6NEQ"
FT HELIX 407..415
FT /evidence="ECO:0007829|PDB:6NEQ"
FT HELIX 418..429
FT /evidence="ECO:0007829|PDB:6NEQ"
FT HELIX 433..439
FT /evidence="ECO:0007829|PDB:6NEQ"
FT STRAND 453..455
FT /evidence="ECO:0007829|PDB:6NEQ"
FT HELIX 461..466
FT /evidence="ECO:0007829|PDB:6NEQ"
FT HELIX 468..470
FT /evidence="ECO:0007829|PDB:6NEQ"
FT HELIX 474..484
FT /evidence="ECO:0007829|PDB:6NEQ"
FT TURN 485..488
FT /evidence="ECO:0007829|PDB:6NEQ"
FT HELIX 493..506
FT /evidence="ECO:0007829|PDB:6NEQ"
FT HELIX 512..521
FT /evidence="ECO:0007829|PDB:6NEQ"
FT STRAND 524..526
FT /evidence="ECO:0007829|PDB:6NEQ"
FT TURN 527..530
FT /evidence="ECO:0007829|PDB:6NEQ"
FT HELIX 531..536
FT /evidence="ECO:0007829|PDB:6NEQ"
FT TURN 537..540
FT /evidence="ECO:0007829|PDB:6NEQ"
FT HELIX 545..547
FT /evidence="ECO:0007829|PDB:6NEQ"
FT HELIX 550..559
FT /evidence="ECO:0007829|PDB:6NEQ"
FT HELIX 582..587
FT /evidence="ECO:0007829|PDB:6NEQ"
FT HELIX 593..601
FT /evidence="ECO:0007829|PDB:6NEQ"
FT STRAND 604..606
FT /evidence="ECO:0007829|PDB:6NEQ"
FT TURN 613..616
FT /evidence="ECO:0007829|PDB:6NEQ"
FT TURN 625..627
FT /evidence="ECO:0007829|PDB:6NEQ"
FT HELIX 628..640
FT /evidence="ECO:0007829|PDB:6NEQ"
SQ SEQUENCE 688 AA; 77831 MW; 7A95BAA060753958 CRC64;
MASVASARWL RVSCGLCVPL TARRAGPCGR TPSSRFYSGS AAVPKDEGAD IAGTEEVVIP
KKKTWDKVAV LQALASTVHR DTTAAPYAFQ DDPYLIPTSS VESHSFLLAK KSGENAAKFI
INSYPKYFQK DIAEPHIPCL MPEYFEPQIE EISEAALQER IKLKKVKASV DIFDQLLQAG
TTVSLETTNS LLDLLCYYGN QEPSTNYNFQ QHEQTEELEE AEEGDNMKSK KKAGHQLGVT
WRARNHAERI FALMPEKNAH SYCTMIRGMV KHRAHTQALS MYTELLNNRL RADVHTFNSL
IEATALVVNA KFEEKWNNIL DLLKQMVAQN VKPNLQTFNT ILKCLRRFYA FGKLPALQTF
REMKAIGIEP SLATYHHIIQ LFYQHESPSK GSSLIIYDIM DEITGKTFSP KDPDDDMFFQ
SAMRVCSSLR DLELAYQVHG LLNTGDNRKF IGPDPRRNFY YSKFFSLLCL MEQIDVTLKW
YKDLIPSVFF PHSQTLIDLL QALDVANRLE MIPQIWKDSK EYGHTFRSDL KEEILMLMAR
DQHPPELQAA FADCAADIKS TYESQDARQT ASEWPANSLN YIAILFLRAG RTQEAWKMLG
LFRKHNKIPR NELLNEFMDS AKASSSPAQA VEVVKLANSF SLPICEGLTQ RLTADFTLSQ
EQKEALGDLT ALTSDSESDS DSDTSKDK
