PTCD3_DROME
ID PTCD3_DROME Reviewed; 652 AA.
AC A1Z9A8; Q8MRC2;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Protein PTCD3 homolog, mitochondrial;
DE Flags: Precursor;
GN ORFNames=CG4679;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- FUNCTION: Mitochondrial protein that may have a role in mitochondrial
CC translation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the mitochondrion-specific ribosomal protein
CC mS39 family. {ECO:0000305}.
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DR EMBL; AE013599; AAF58398.1; -; Genomic_DNA.
DR EMBL; AY121671; AAM51998.1; -; mRNA.
DR RefSeq; NP_610854.1; NM_137010.3.
DR AlphaFoldDB; A1Z9A8; -.
DR SMR; A1Z9A8; -.
DR BioGRID; 62229; 3.
DR IntAct; A1Z9A8; 1.
DR STRING; 7227.FBpp0086872; -.
DR PaxDb; A1Z9A8; -.
DR PRIDE; A1Z9A8; -.
DR EnsemblMetazoa; FBtr0087759; FBpp0086872; FBgn0033816.
DR GeneID; 36466; -.
DR KEGG; dme:Dmel_CG4679; -.
DR UCSC; CG4679-RA; d. melanogaster.
DR FlyBase; FBgn0033816; CG4679.
DR VEuPathDB; VectorBase:FBgn0033816; -.
DR eggNOG; KOG4422; Eukaryota.
DR HOGENOM; CLU_026264_0_1_1; -.
DR InParanoid; A1Z9A8; -.
DR OMA; FMHQEAQ; -.
DR OrthoDB; 405419at2759; -.
DR PhylomeDB; A1Z9A8; -.
DR Reactome; R-DME-5389840; Mitochondrial translation elongation.
DR Reactome; R-DME-5419276; Mitochondrial translation termination.
DR BioGRID-ORCS; 36466; 1 hit in 1 CRISPR screen.
DR GenomeRNAi; 36466; -.
DR PRO; PR:A1Z9A8; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0033816; Expressed in adult Malpighian tubule (Drosophila) and 50 other tissues.
DR ExpressionAtlas; A1Z9A8; baseline and differential.
DR Genevisible; A1Z9A8; DM.
DR GO; GO:0005739; C:mitochondrion; HDA:FlyBase.
DR GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW.
DR GO; GO:0043024; F:ribosomal small subunit binding; ISS:UniProtKB.
DR GO; GO:0019843; F:rRNA binding; ISS:UniProtKB.
DR GO; GO:0032543; P:mitochondrial translation; ISS:UniProtKB.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR002885; Pentatricopeptide_repeat.
DR InterPro; IPR037387; PTCD3.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR16276; PTHR16276; 1.
DR Pfam; PF13812; PPR_3; 1.
PE 2: Evidence at transcript level;
KW Mitochondrion; Reference proteome; Ribonucleoprotein; Ribosomal protein;
KW RNA-binding; rRNA-binding; Transit peptide; Translation regulation.
FT TRANSIT 1..37
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 38..652
FT /note="Protein PTCD3 homolog, mitochondrial"
FT /id="PRO_0000305034"
FT CONFLICT 98
FT /note="K -> R (in Ref. 3; AAM51998)"
FT /evidence="ECO:0000305"
FT CONFLICT 412
FT /note="K -> E (in Ref. 3; AAM51998)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 652 AA; 74207 MW; E0964202B85D1987 CRC64;
MYLSRQLRLL PRANIACSLS SSGAHYTTAA PAEDAPIEIP NRIERSPTDL LQALASTVAR
DYTAPHYKYH DDPFLIPMSN AAKRTYAMSK ESGRKAAKWI KEEHRELFMH QEAQPAIEKF
APSMVYTEDS VVDETSLAQL ISQGELKDAV LVYNLLEQKG NPISPELKQS LLELVCFHNN
QEPIPEEYIE ERWFLQNNKR RERSGKTWKD GDLAEKLYSE IEPKTPQSYA SLIRGMAKYL
QCERAYALLQ EAGEKQVQLD TNTFNSVIEI VSFLKDTAEQ RWQLCKDLLN EMSQQKLRPN
LGTLNAVLQC ISTFGNFKVA RAAALQALPE FKQLGVNPSL GSYYYLLIIF CRERGPVSHV
IVDILNDISG KEFQIQHPKD TYFFATAMDV CRNHLHDKSL AKKVDELLHT GKNYDLVGDS
FKESIYYRNY LALLCQTEST EDFMLSYDLL VPNIYIPEPG IMEEILRAIE INGAVEYVPR
LWSDMVVFDH THRESLLLYV LRILVDNKPN PDSPAQAQLP EQGAKVALDM FERVEEAIKR
LRKVSFTGQM LGDILTLLVR GGSYEKATEV FAHIDKNQHR IPGTPSLNAL IEFVDASVQE
KSPSQALFAL QYAVENNFDS RELAKRIHEG FTLNETHLSK LKSLVGESFL DK
