PTCD3_MOUSE
ID PTCD3_MOUSE Reviewed; 685 AA.
AC Q14C51; Q3UKH5; Q5XG65; Q6P9N5; Q9CZ12;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 02-OCT-2007, sequence version 2.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Pentatricopeptide repeat domain-containing protein 3, mitochondrial;
DE AltName: Full=28S ribosomal protein S39, mitochondrial;
DE Short=MRP-S39;
DE Flags: Precursor;
GN Name=Ptcd3; Synonyms=Mrps39;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Placenta;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Bone, and Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Mitochondrial RNA-binding protein that has a role in
CC mitochondrial translation. {ECO:0000250}.
CC -!- SUBUNIT: Component of the mitochondrial ribosome small subunit (28S)
CC which comprises a 12S rRNA and about 30 distinct proteins. Associated
CC with the 12S mitochondrial rRNA (12S mt-rRNA) (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the mitochondrion-specific ribosomal protein
CC mS39 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB28668.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK013131; BAB28668.1; ALT_INIT; mRNA.
DR EMBL; AK146005; BAE26826.1; -; mRNA.
DR EMBL; BC060687; AAH60687.1; -; mRNA.
DR EMBL; BC084595; AAH84595.1; -; mRNA.
DR EMBL; BC115434; AAI15435.1; -; mRNA.
DR CCDS; CCDS20235.1; -.
DR RefSeq; NP_081551.2; NM_027275.3.
DR AlphaFoldDB; Q14C51; -.
DR SMR; Q14C51; -.
DR BioGRID; 213775; 9.
DR ComplexPortal; CPX-5301; 28S mitochondrial small ribosomal subunit.
DR IntAct; Q14C51; 1.
DR STRING; 10090.ENSMUSP00000080743; -.
DR iPTMnet; Q14C51; -.
DR PhosphoSitePlus; Q14C51; -.
DR EPD; Q14C51; -.
DR jPOST; Q14C51; -.
DR MaxQB; Q14C51; -.
DR PaxDb; Q14C51; -.
DR PeptideAtlas; Q14C51; -.
DR PRIDE; Q14C51; -.
DR ProteomicsDB; 291615; -.
DR Antibodypedia; 32009; 69 antibodies from 21 providers.
DR DNASU; 69956; -.
DR Ensembl; ENSMUST00000082094; ENSMUSP00000080743; ENSMUSG00000063884.
DR GeneID; 69956; -.
DR KEGG; mmu:69956; -.
DR UCSC; uc009chq.1; mouse.
DR CTD; 55037; -.
DR MGI; MGI:1917206; Ptcd3.
DR VEuPathDB; HostDB:ENSMUSG00000063884; -.
DR eggNOG; KOG4422; Eukaryota.
DR GeneTree; ENSGT00390000016876; -.
DR HOGENOM; CLU_026264_0_1_1; -.
DR InParanoid; Q14C51; -.
DR OMA; FMHQEAQ; -.
DR OrthoDB; 405419at2759; -.
DR PhylomeDB; Q14C51; -.
DR TreeFam; TF320158; -.
DR Reactome; R-MMU-5389840; Mitochondrial translation elongation.
DR Reactome; R-MMU-5419276; Mitochondrial translation termination.
DR BioGRID-ORCS; 69956; 19 hits in 73 CRISPR screens.
DR ChiTaRS; Ptcd3; mouse.
DR PRO; PR:Q14C51; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q14C51; protein.
DR Bgee; ENSMUSG00000063884; Expressed in spermatocyte and 140 other tissues.
DR ExpressionAtlas; Q14C51; baseline and differential.
DR Genevisible; Q14C51; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005743; C:mitochondrial inner membrane; IC:ComplexPortal.
DR GO; GO:0005763; C:mitochondrial small ribosomal subunit; IC:ComplexPortal.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0043024; F:ribosomal small subunit binding; ISS:UniProtKB.
DR GO; GO:0019843; F:rRNA binding; ISS:UniProtKB.
DR GO; GO:0032543; P:mitochondrial translation; ISS:UniProtKB.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.10; -; 2.
DR InterPro; IPR002885; Pentatricopeptide_repeat.
DR InterPro; IPR037387; PTCD3.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR16276; PTHR16276; 1.
DR Pfam; PF13812; PPR_3; 1.
DR PROSITE; PS51375; PPR; 3.
PE 1: Evidence at protein level;
KW Acetylation; Mitochondrion; Reference proteome; Repeat; Ribonucleoprotein;
KW Ribosomal protein; RNA-binding; rRNA-binding; Transit peptide;
KW Translation regulation.
FT TRANSIT 1..10
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 11..685
FT /note="Pentatricopeptide repeat domain-containing protein
FT 3, mitochondrial"
FT /id="PRO_0000305029"
FT REPEAT 150..184
FT /note="PPR 1"
FT REPEAT 185..220
FT /note="PPR 2"
FT REPEAT 254..288
FT /note="PPR 3"
FT REPEAT 289..329
FT /note="PPR 4"
FT REPEAT 330..366
FT /note="PPR 5"
FT REPEAT 367..407
FT /note="PPR 6"
FT REPEAT 412..446
FT /note="PPR 7"
FT REPEAT 454..488
FT /note="PPR 8"
FT REPEAT 489..523
FT /note="PPR 9"
FT REPEAT 572..606
FT /note="PPR 10"
FT REGION 663..685
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 127
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q96EY7"
FT CONFLICT 279
FT /note="T -> A (in Ref. 2; AAI15435)"
FT /evidence="ECO:0000305"
FT CONFLICT 563
FT /note="S -> G (in Ref. 2; AAI15435)"
FT /evidence="ECO:0000305"
FT CONFLICT 589
FT /note="S -> T (in Ref. 2; AAI15435)"
FT /evidence="ECO:0000305"
FT CONFLICT 603
FT /note="K -> N (in Ref. 2; AAI15435)"
FT /evidence="ECO:0000305"
FT CONFLICT 605
FT /note="I -> T (in Ref. 1; BAE26826)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 685 AA; 77796 MW; 10BD1C0ACC348BAE CRC64;
MAAAAVAARR LSFRSGLVLL QTTRGTGVCE PKVCCRFYAG TESLPKVEGS DITGIEEIVI
PKKKTWDKVA VLQALASTVN RDPTAAPYVF HDDPYLIPTS ALESRSFLLA KKSGETAAKF
IINSYPKYFQ KDIAEPHIPC LMPEYFEPQI EDVSEAALEE RIRLRKVRAS VDMFDQLLQA
GTTVSLETTN SLLDLLCYYG DQEPPADYPF QQTEHLENLE EAAEENNQTS KMESGPWKAQ
NNAERIFALM PEKNARSYCT MIRGMVKHRA YAQALNVYTE LLNNRLSADV YTFNALIEAK
TFILNEKFEE KWNDILDLLK HMVAQKVKPN LQTFNTILKG LRKCYSLGRI PALQILREMK
HIGIEPSLAT YHHIIHLFYP RDLSAIKMPS LIIYDIMNEL EGRTFSPQDL DDGRFFQLAM
SVCSSLRDLE LAYQVHRLLN TGDNRKLVGH DPLRKVYYSK FFSLICSLEQ IDVTLKWYKD
LIPSVFLPHY QIFIGLLQAL DVANRLELVP QIWKDSKEYS HTFRDALREE VLMLMARDKH
PPELQVAFAD CAADIKSTYE DQSARQPAFD WPANPLQYIA VLFLRGGRSQ EAWKMLELFK
KHKKIPRNEL LEEFMDTAKA SGSTALAIEV VKLASAFSLP IGESLAQRVV MDFTVDPEQK
EALGNLTELN SSDGESSSDS DSDDK
