ID   PTCD3_PONAB             Reviewed;         689 AA.
AC   Q5R8W8;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Pentatricopeptide repeat domain-containing protein 3, mitochondrial;
DE   AltName: Full=28S ribosomal protein S39, mitochondrial;
DE            Short=MRP-S39;
DE   Flags: Precursor;
GN   Name=PTCD3; Synonyms=MRPS39;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mitochondrial RNA-binding protein that has a role in
CC       mitochondrial translation. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the mitochondrial ribosome small subunit (28S)
CC       which comprises a 12S rRNA and about 30 distinct proteins. Associated
CC       with the 12S mitochondrial rRNA (12S mt-rRNA) (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the mitochondrion-specific ribosomal protein
CC       mS39 family. {ECO:0000305}.
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DR   EMBL; CR859630; CAH91792.1; -; mRNA.
DR   RefSeq; NP_001126041.1; NM_001132569.2.
DR   AlphaFoldDB; Q5R8W8; -.
DR   SMR; Q5R8W8; -.
DR   STRING; 9601.ENSPPYP00000013622; -.
DR   PRIDE; Q5R8W8; -.
DR   GeneID; 100172990; -.
DR   KEGG; pon:100172990; -.
DR   CTD; 55037; -.
DR   eggNOG; KOG4422; Eukaryota.
DR   InParanoid; Q5R8W8; -.
DR   OrthoDB; 405419at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW.
DR   GO; GO:0043024; F:ribosomal small subunit binding; ISS:UniProtKB.
DR   GO; GO:0019843; F:rRNA binding; ISS:UniProtKB.
DR   GO; GO:0032543; P:mitochondrial translation; ISS:UniProtKB.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.10; -; 2.
DR   InterPro; IPR002885; Pentatricopeptide_repeat.
DR   InterPro; IPR037387; PTCD3.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR16276; PTHR16276; 1.
DR   Pfam; PF13041; PPR_2; 1.
DR   Pfam; PF13812; PPR_3; 1.
DR   PROSITE; PS51375; PPR; 4.
PE   2: Evidence at transcript level;
KW   Acetylation; Mitochondrion; Reference proteome; Repeat; Ribonucleoprotein;
KW   Ribosomal protein; RNA-binding; rRNA-binding; Transit peptide;
KW   Translation regulation.
FT   TRANSIT         1..37
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           38..689
FT                   /note="Pentatricopeptide repeat domain-containing protein
FT                   3, mitochondrial"
FT                   /id="PRO_0000305030"
FT   REPEAT          149..183
FT                   /note="PPR 1"
FT   REPEAT          184..219
FT                   /note="PPR 2"
FT   REPEAT          255..289
FT                   /note="PPR 3"
FT   REPEAT          290..330
FT                   /note="PPR 4"
FT   REPEAT          331..367
FT                   /note="PPR 5"
FT   REPEAT          368..404
FT                   /note="PPR 6"
FT   REPEAT          412..446
FT                   /note="PPR 7"
FT   REPEAT          454..488
FT                   /note="PPR 8"
FT   REPEAT          489..523
FT                   /note="PPR 9"
FT   REPEAT          572..606
FT                   /note="PPR 10"
FT   REGION          665..689
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         126
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96EY7"
SQ   SEQUENCE   689 AA;  78604 MW;  AE7194F1B125F854 CRC64;
     MAGVSAVRWL GLRSRLGQPL TGRRAGLCKQ ARSCRFYSGS ATLSKVEGTD ITGIEEVVIP
     KKKTWDKVAV LQALASTVNR DTTSVPYVFQ DDPYLIPASS LESRLFLLAK KSGENVAKFI
     INSYPKYFQK DIAEPHIPCL MPEYFEPQIK DISEAALKER IELRKVKASV DMFDQLLQAG
     TTVSLETTNS LLDLLCYFGD QEPSTDYHFQ QTEQSEALEV ENDETSRRKA GHQFGVTWQA
     KNNAERIFSL MPEKNAHSYC TMIRGMVKHR AYEQALNLYT ELLNNRLHAD VYTFNALTEA
     TVCVINGKFE EKWSKIQELL RHMVAQKVKP NLQTFNTILK CLRRFHVFAR SPALRILREM
     KAIGIEPSLA TYHHIIHVFD QPGDPLKRSS FIIYDIMNEL MGKRFSPKDP DDDKFFQSAM
     SICSSLRDLE LAYQVHGLLN TGDNWKFIGP DHHRNFYYSK FFDLICLMEQ IDVTLKWYED
     LIPSVYFPHS QTLIHLLQAL DVANRLEMIP KIWKDSKEYG HTFRSDLREE ILKLMARDKH
     PPELQVAFAD CAADIKSAYE SQHIRQTAQD WPATSLYCIA ILFLRAGRTQ EAWNMLELFR
     KHNKIPRSEL LNELMDSAKV SNSPSQAIEV VELASAFSLP ICEGLTQRVM SDFAINQEQK
     EALGNLTALT SDSDTDSSSD SDSDTSEGK