PTCRA_BOVIN
ID PTCRA_BOVIN Reviewed; 319 AA.
AC Q0VCS0;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=Pre T-cell antigen receptor alpha;
DE Short=pT-alpha;
DE Short=pTa;
DE AltName: Full=pT-alpha-TCR;
DE Flags: Precursor;
GN Name=PTCRA;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Thymus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: The pre-T-cell receptor complex (composed of PTCRA, TCRB and
CC the CD3 complex) regulates early T-cell development. {ECO:0000250}.
CC -!- SUBUNIT: Heterodimer with TCRB; disulfide linked. This heterodimer
CC assembles with CD3 proteins into a signaling-competent pre-T-cell
CC receptor complex. Interacts with RHBDD1 (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
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DR EMBL; BC120034; AAI20035.1; -; mRNA.
DR RefSeq; NP_001069101.1; NM_001075633.1.
DR AlphaFoldDB; Q0VCS0; -.
DR SMR; Q0VCS0; -.
DR STRING; 9913.ENSBTAP00000044273; -.
DR PaxDb; Q0VCS0; -.
DR Ensembl; ENSBTAT00000047035; ENSBTAP00000044273; ENSBTAG00000017097.
DR GeneID; 513669; -.
DR KEGG; bta:513669; -.
DR CTD; 171558; -.
DR VEuPathDB; HostDB:ENSBTAG00000017097; -.
DR VGNC; VGNC:33494; PTCRA.
DR eggNOG; ENOG502SAGI; Eukaryota.
DR GeneTree; ENSGT00390000007712; -.
DR HOGENOM; CLU_082600_0_0_1; -.
DR InParanoid; Q0VCS0; -.
DR OMA; ARTCPRE; -.
DR OrthoDB; 1383750at2759; -.
DR TreeFam; TF337868; -.
DR Proteomes; UP000009136; Chromosome 23.
DR Bgee; ENSBTAG00000017097; Expressed in thymus and 26 other tissues.
DR ExpressionAtlas; Q0VCS0; baseline.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0070244; P:negative regulation of thymocyte apoptotic process; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR027834; PTCRA.
DR PANTHER; PTHR37866; PTHR37866; 1.
DR Pfam; PF15028; PTCRA; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Membrane; Receptor; Reference proteome;
KW Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..16
FT /evidence="ECO:0000255"
FT CHAIN 17..319
FT /note="Pre T-cell antigen receptor alpha"
FT /id="PRO_0000319107"
FT TOPO_DOM 17..160
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 161..181
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 182..319
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 189..293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 78
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 58..118
FT /evidence="ECO:0000250"
FT DISULFID 146
FT /note="Interchain (with TCRB)"
FT /evidence="ECO:0000250"
SQ SEQUENCE 319 AA; 33670 MW; 63D2B28F69D33587 CRC64;
MAESWLLLLL ALGCPALPTE VTTLLRPAQQ GMGSTPFPSL APPITLLVDG KQQTLVVCLV
LDVAPPGFES PIWFSAGNGS SLDAFTYGPS PAEDGTWTRL AQLSLYSEEL AAWDTLVCHT
GPGAGDHGQS TQPLQLSGDA SSARTCLWEP LRGTRALVLR LGALRLLLFK LLLLDVLLTC
GRLHAPPAAR GDPAGASGPG APSLPAPHEV PRADSRLLPQ PPPPRGSSSG PADRIRRNHG
GTTGRGLSVS ASPPLEPRDR RRRVHTRRPR RDPRNPVWEE GPPVLRAWSS GPSFSLSTSS
LGAFLCNLPP PADPSFPGG
