ID   PTCRA_RAT               Reviewed;         199 AA.
AC   P0C6B3;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Pre T-cell antigen receptor alpha;
DE            Short=pT-alpha;
DE            Short=pTa;
DE   AltName: Full=pT-alpha-TCR;
DE   Flags: Precursor;
GN   Name=Ptcra;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway;
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 59-164, AND TISSUE SPECIFICITY.
RC   STRAIN=Wistar; TISSUE=Thymocyte;
RX   PubMed=11169403;
RX   DOI=10.1002/1521-4141(200012)30:12<3604::aid-immu3604>3.0.co;2-d;
RA   Alonso-C L.M., Munoz J.J., Zapata A.G.;
RT   "Early T cell development can be traced in rat fetal liver.";
RL   Eur. J. Immunol. 30:3604-3613(2000).
CC   -!- FUNCTION: The pre-T-cell receptor complex (composed of PTCRA, TCRB and
CC       the CD3 complex) regulates early T-cell development. {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer with TCRB; disulfide linked. This heterodimer
CC       assembles with CD3 proteins into a signaling-competent pre-T-cell
CC       receptor complex. Interacts with RHBDD1 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Found in CD45+ but not in the CD45- fetal liver
CC       cells. {ECO:0000269|PubMed:11169403}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EDM18861.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; CH473987; EDM18861.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AF182508; AAG16904.1; -; mRNA.
DR   RefSeq; XP_001065627.1; XM_001065627.4.
DR   RefSeq; XP_003750700.1; XM_003750652.4.
DR   AlphaFoldDB; P0C6B3; -.
DR   SMR; P0C6B3; -.
DR   STRING; 10116.ENSRNOP00000059713; -.
DR   GlyGen; P0C6B3; 2 sites.
DR   PaxDb; P0C6B3; -.
DR   GeneID; 116462; -.
DR   KEGG; rno:116462; -.
DR   CTD; 171558; -.
DR   RGD; 621388; Ptcra.
DR   VEuPathDB; HostDB:ENSRNOG00000042581; -.
DR   eggNOG; ENOG502SAGI; Eukaryota.
DR   HOGENOM; CLU_099078_0_0_1; -.
DR   InParanoid; P0C6B3; -.
DR   OrthoDB; 1389406at2759; -.
DR   PhylomeDB; P0C6B3; -.
DR   PRO; PR:P0C6B3; -.
DR   Proteomes; UP000002494; Chromosome 9.
DR   Proteomes; UP000234681; Chromosome 9.
DR   Bgee; ENSRNOG00000042581; Expressed in thymus and 5 other tissues.
DR   ExpressionAtlas; P0C6B3; baseline.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0070244; P:negative regulation of thymocyte apoptotic process; ISO:RGD.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR027834; PTCRA.
DR   PANTHER; PTHR37866; PTHR37866; 1.
DR   Pfam; PF15028; PTCRA; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Membrane; Receptor; Reference proteome;
KW   Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   CHAIN           17..199
FT                   /note="Pre T-cell antigen receptor alpha"
FT                   /id="PRO_0000319110"
FT   TOPO_DOM        17..155
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        156..176
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        177..199
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          117..139
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        119..139
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        67
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        117
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        47..107
FT                   /evidence="ECO:0000250"
FT   DISULFID        136
FT                   /note="Interchain (with TCRB)"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   199 AA;  21340 MW;  3014693F238A4067 CRC64;
     MARTWLLLFL GLRCQALPSG IAGTPFPSLA PPVTLLVDGR RHTLVVCLVL DAAPPGLDSL
     VWFSGGNGSA LDAFTYGPSP APDGTWTSLG QLSLSSEELE AWEPLVCHTR PAAGGLNRST
     HPLQLSGEEA STDRTCPQET LRGTQRQVLR LSVLRLLLFK LLLLDVFLTC SRLCVLAGQH
     LLPPPSSKQA PASTHQSWT