PTD_ARATH
ID PTD_ARATH Reviewed; 250 AA.
AC F4IDW9; Q1WW75; Q8L9H8; Q9LPX0;
DT 30-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 25-MAY-2022, entry version 63.
DE RecName: Full=Protein PARTING DANCERS {ECO:0000303|PubMed:16394097};
DE Short=AtPTD {ECO:0000303|PubMed:16394097};
DE EC=3.1.-.- {ECO:0000305};
GN Name=PTD {ECO:0000303|PubMed:16394097};
GN OrderedLocusNames=At1g12790 {ECO:0000312|Araport:AT1G12790};
GN ORFNames=F13K23.4 {ECO:0000312|EMBL:AAF78484.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Shinn P., Chen H., Kim C.J., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RC STRAIN=cv. Columbia;
RX PubMed=16394097; DOI=10.1091/mbc.e05-09-0902;
RA Wijeratne A.J., Chen C., Zhang W., Timofejeva L., Ma H.;
RT "The Arabidopsis thaliana PARTING DANCERS gene encoding a novel protein is
RT required for normal meiotic homologous recombination.";
RL Mol. Biol. Cell 17:1331-1343(2006).
RN [6]
RP REVIEW ON CROSSOVERS.
RX PubMed=17208327; DOI=10.1016/j.tig.2006.12.007;
RA Mezard C., Vignard J., Drouaud J., Mercier R.;
RT "The road to crossovers: plants have their say.";
RL Trends Genet. 23:91-99(2007).
RN [7]
RP FUNCTION, DISRUPTION PHENOTYPE, AND INTERACTION WITH SHOC1.
RC STRAIN=cv. Columbia;
RX PubMed=21771883; DOI=10.1242/jcs.088229;
RA Macaisne N., Vignard J., Mercier R.;
RT "SHOC1 and PTD form an XPF-ERCC1-like complex that is required for
RT formation of class I crossovers.";
RL J. Cell Sci. 124:2687-2691(2011).
RN [8]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=cv. Columbia;
RX PubMed=24656236; DOI=10.1016/j.jgg.2014.02.001;
RA Lu P., Wijeratne A.J., Wang Z., Copenhaver G.P., Ma H.;
RT "Arabidopsis PTD is required for type I crossover formation and affects
RT recombination frequency in two different chromosomal regions.";
RL J. Genet. Genomics 41:165-175(2014).
CC -!- FUNCTION: Required for chromosome segregation during meiosis
CC (PubMed:16394097). During diakinesis and prometaphase I, essential for
CC the formation of class I meiotic crossovers and homologous
CC recombination (PubMed:16394097, PubMed:21771883, PubMed:24656236).
CC {ECO:0000269|PubMed:16394097, ECO:0000269|PubMed:21771883,
CC ECO:0000269|PubMed:24656236}.
CC -!- SUBUNIT: Interacts with SHOC1. {ECO:0000269|PubMed:21771883}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in roots, stems, leaves, siliques,
CC flowers, inflorescence and anthers. Strongly expressed in meiocytes.
CC {ECO:0000269|PubMed:16394097}.
CC -!- DEVELOPMENTAL STAGE: Expressed in the shoot apical meristem (SAM) and
CC young flower buds. In mature flowers, restricted to the reproductive
CC organs stamens and carpels. In the stamen, accumulates in male
CC meiocytes and in tapetal cells, as well as in mature pollen grains. In
CC the carpel, present in developing ovules and in developing embryos.
CC {ECO:0000269|PubMed:16394097}.
CC -!- DISRUPTION PHENOTYPE: Reduction in the number of class I crossovers
CC (COs) during meiosis (PubMed:21771883, PubMed:16394097,
CC PubMed:24656236). Delay in the formation of synaptonemal complexes (SC)
CC as well as a few unsynapsed axial elements in early pachytene nuclei in
CC some meiocytes. Early nodules (ENs) are observed on the central element
CC of SC. Reduced fertility due to altered male and female meiosis
CC (PubMed:16394097). {ECO:0000269|PubMed:16394097,
CC ECO:0000269|PubMed:21771883, ECO:0000269|PubMed:24656236}.
CC -!- SIMILARITY: Belongs to the ERCC1/RAD10/SWI10 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF78484.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC012187; AAF78484.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE28929.1; -; Genomic_DNA.
DR EMBL; BT025031; ABE02406.1; -; mRNA.
DR EMBL; AY088424; AAM65961.1; -; mRNA.
DR PIR; C86261; C86261.
DR RefSeq; NP_563913.1; NM_101149.4.
DR AlphaFoldDB; F4IDW9; -.
DR STRING; 3702.AT1G12790.1; -.
DR PaxDb; F4IDW9; -.
DR PRIDE; F4IDW9; -.
DR EnsemblPlants; AT1G12790.1; AT1G12790.1; AT1G12790.
DR GeneID; 837835; -.
DR Gramene; AT1G12790.1; AT1G12790.1; AT1G12790.
DR KEGG; ath:AT1G12790; -.
DR Araport; AT1G12790; -.
DR TAIR; locus:2010321; AT1G12790.
DR eggNOG; ENOG502QRWT; Eukaryota.
DR HOGENOM; CLU_080281_0_0_1; -.
DR InParanoid; F4IDW9; -.
DR OMA; REQNDSF; -.
DR OrthoDB; 1104615at2759; -.
DR PRO; PR:F4IDW9; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; F4IDW9; baseline and differential.
DR GO; GO:0005694; C:chromosome; IEA:EnsemblPlants.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0007059; P:chromosome segregation; IMP:UniProtKB.
DR GO; GO:0007140; P:male meiotic nuclear division; IMP:UniProtKB.
DR GO; GO:0048236; P:plant-type sporogenesis; IMP:UniProtKB.
DR GO; GO:0009555; P:pollen development; IMP:UniProtKB.
DR GO; GO:0010845; P:positive regulation of reciprocal meiotic recombination; IMP:UniProtKB.
DR GO; GO:0007131; P:reciprocal meiotic recombination; IMP:UniProtKB.
DR GO; GO:0000712; P:resolution of meiotic recombination intermediates; IMP:UniProtKB.
DR InterPro; IPR039172; PTD.
DR InterPro; IPR010994; RuvA_2-like.
DR PANTHER; PTHR37394; PTHR37394; 1.
DR SUPFAM; SSF47781; SSF47781; 1.
PE 1: Evidence at protein level;
KW DNA recombination; Endonuclease; Hydrolase; Meiosis; Nuclease; Nucleus;
KW Reference proteome.
FT CHAIN 1..250
FT /note="Protein PARTING DANCERS"
FT /id="PRO_0000438324"
FT CONFLICT 14
FT /note="H -> N (in Ref. 4; AAM65961)"
FT /evidence="ECO:0000305"
FT CONFLICT 87
FT /note="F -> C (in Ref. 4; AAM65961)"
FT /evidence="ECO:0000305"
FT CONFLICT 144
FT /note="A -> G (in Ref. 4; AAM65961)"
FT /evidence="ECO:0000305"
FT CONFLICT 229
FT /note="K -> E (in Ref. 4; AAM65961)"
FT /evidence="ECO:0000305"
FT CONFLICT 244
FT /note="Y -> D (in Ref. 3; ABE02406)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 250 AA; 27894 MW; 4DD93B49975E8BEB CRC64;
MATAGSSYSV STDHQVSSPL VNLGNVAGVC IMSNAWKVEQ EPSLINFISA FLSANSFRLN
FVSIPPDLIF NCGGVSIAFV FVTKWDFSNV ASIFSRVKRL KGQFAQLYVV ATLSTKEQSD
SFMRSYFQYE MEFGKPAFVQ VTDAEMGFEK IVKIAHSRGV CKQQKVASKL KVERKRTVQD
TNIFIRFVTS IPNINKHDAN TLYQAIGSIE AIAKASKEDI LANTDLSSKK ADTLTRFFQD
PEFYLSPKFN
