ID   ATP23_DICDI             Reviewed;         242 AA.
AC   Q55CA5;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-MAY-2006, sequence version 2.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Mitochondrial inner membrane protease ATP23 homolog;
DE            EC=3.4.24.-;
GN   ORFNames=DDB_G0270738;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- SIMILARITY: Belongs to the peptidase M76 family. {ECO:0000305}.
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DR   EMBL; AAFI02000005; EAL72719.2; -; Genomic_DNA.
DR   RefSeq; XP_646576.2; XM_641484.2.
DR   AlphaFoldDB; Q55CA5; -.
DR   STRING; 44689.DDB0201962; -.
DR   MEROPS; M76.A03; -.
DR   PaxDb; Q55CA5; -.
DR   PRIDE; Q55CA5; -.
DR   EnsemblProtists; EAL72719; EAL72719; DDB_G0270738.
DR   GeneID; 8617546; -.
DR   KEGG; ddi:DDB_G0270738; -.
DR   dictyBase; DDB_G0270738; -.
DR   eggNOG; KOG3314; Eukaryota.
DR   HOGENOM; CLU_079125_1_1_1; -.
DR   InParanoid; Q55CA5; -.
DR   OMA; VDHLACT; -.
DR   PhylomeDB; Q55CA5; -.
DR   PRO; PR:Q55CA5; -.
DR   Proteomes; UP000002195; Chromosome 1.
DR   GO; GO:0031314; C:extrinsic component of mitochondrial inner membrane; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0034982; P:mitochondrial protein processing; IBA:GO_Central.
DR   GO; GO:0033615; P:mitochondrial proton-transporting ATP synthase complex assembly; IBA:GO_Central.
DR   InterPro; IPR019165; Peptidase_M76_ATP23.
DR   PANTHER; PTHR21711; PTHR21711; 1.
DR   Pfam; PF09768; Peptidase_M76; 1.
DR   PROSITE; PS00142; ZINC_PROTEASE; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Metal-binding; Metalloprotease; Protease; Reference proteome.
FT   CHAIN           1..242
FT                   /note="Mitochondrial inner membrane protease ATP23 homolog"
FT                   /id="PRO_0000330349"
FT   ACT_SITE        145
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10095"
FT   BINDING         144
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000250"
FT   BINDING         148
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   242 AA;  27462 MW;  A5E1D34F66FD31A6 CRC64;
     MTISDSIKNI LLLKNNNNKN NDNNKIENDN YDVIICSHKI NSKNEEIPPT DDDTTTNGGG
     SLNKYVRKPT NQMCRENVEK TFKEDPILQF IIKEMMKLGC LPPVITCEPC DSLDALGSFT
     PKKGVIICDN MPTFPLNIRN TVVHEFVHAY DMCKNKLNPF NCEHLACTEI RAANLSGDCK
     WQLEALKKNF GVFNHQAECA KRRAIGSLQS NPNCKDVAEM AVNKVWEKCN KDYYPFSNIP
     RI