ID   PTEG_XENLA              Reviewed;         122 AA.
AC   Q6XQ84;
DT   02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 48.
DE   RecName: Full=Proximal tubules-expressed gene protein {ECO:0000303|PubMed:19909807};
DE            Short=Xpteg {ECO:0000303|PubMed:19909807};
DE   AltName: Full=MAP17-like protein {ECO:0000303|PubMed:19909807};
DE   AltName: Full=PDZK1-interacting protein 1-like {ECO:0000250|UniProtKB:Q13113};
GN   Name=pteg;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:AAP51037.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL
RP   STAGE, AND INDUCTION.
RC   TISSUE=Tadpole {ECO:0000269|PubMed:19909807};
RX   PubMed=19909807; DOI=10.1016/j.mod.2009.11.001;
RA   Lee S.J., Kim S., Choi S.C., Han J.K.;
RT   "XPteg (Xenopus proximal tubules-expressed gene) is essential for
RT   pronephric mesoderm specification and tubulogenesis.";
RL   Mech. Dev. 127:49-61(2010).
RN   [2] {ECO:0000312|EMBL:AAI69478.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential for pronephric tubule development, acting upstream
CC       of pax8 and lhx1/lim1 and downstream of retinoic acid signaling to
CC       induce pronephric mesoderm to form pronephric tubule-specific cells.
CC       {ECO:0000269|PubMed:19909807}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC       protein {ECO:0000255}.
CC   -!- TISSUE SPECIFICITY: Expressed in prospective pronephric mesoderm at the
CC       late gastrula stage. After neurulation, expressed in the intermediate
CC       mesoderm, eye placode and blood islands. Expression becomes restricted
CC       to the pronephric proximal tubule during embryogenesis, but is absent
CC       from the connecting tubules. {ECO:0000269|PubMed:19909807}.
CC   -!- DEVELOPMENTAL STAGE: Expressed zygotically from late gastrula stages,
CC       persisting throughout embryogenesis with highest expression between
CC       stages 30 and 35. {ECO:0000269|PubMed:19909807}.
CC   -!- INDUCTION: By retinoic acid. {ECO:0000269|PubMed:19909807}.
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DR   EMBL; AY216664; AAP51037.1; -; mRNA.
DR   EMBL; AY216665; AAP51038.1; -; mRNA.
DR   EMBL; BC169478; AAI69478.1; -; mRNA.
DR   EMBL; BC169480; AAI69480.1; -; mRNA.
DR   RefSeq; NP_001091905.1; NM_001098435.1.
DR   AlphaFoldDB; Q6XQ84; -.
DR   SMR; Q6XQ84; -.
DR   GeneID; 445820; -.
DR   KEGG; xla:445820; -.
DR   CTD; 445820; -.
DR   Xenbase; XB-GENE-5829591; pdzk1ip1.S.
DR   OMA; VVYVAKM; -.
DR   OrthoDB; 1536451at2759; -.
DR   Proteomes; UP000186698; Chromosome 4S.
DR   Bgee; 445820; Expressed in kidney and 13 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0039020; P:pronephric nephron tubule development; IMP:UniProtKB.
DR   GO; GO:0048793; P:pronephros development; IMP:UniProtKB.
DR   GO; GO:0072116; P:pronephros formation; IMP:UniProtKB.
DR   GO; GO:0048384; P:retinoic acid receptor signaling pathway; IMP:UniProtKB.
DR   InterPro; IPR026628; PDZK-int_prot1.
DR   InterPro; IPR031627; PDZK1IP1/SMIM24.
DR   PANTHER; PTHR15296; PTHR15296; 1.
DR   PANTHER; PTHR15296:SF0; PTHR15296:SF0; 1.
DR   Pfam; PF15807; MAP17; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..122
FT                   /note="Proximal tubules-expressed gene protein"
FT                   /id="PRO_0000391693"
FT   TRANSMEM        33..53
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   122 AA;  14078 MW;  3767DCC01949E096 CRC64;
     MFSLQHVLLI LISLGQVYSQ QVHHNAGRKF PQWLTGLIAM TVFLFLVLVV YVAKMFWDKR
     SQESINMKDI EEVVANGTSE CCEARKENQY ISCNMKDLRS SEHIHAYENP IEVNDNVRST
     AM