AAD14_YEAST
ID AAD14_YEAST Reviewed; 376 AA.
AC P42884; D6W0L6;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Putative aryl-alcohol dehydrogenase AAD14;
DE EC=1.1.1.-;
GN Name=AAD14; OrderedLocusNames=YNL331C; ORFNames=N0300;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 96604 / S288c / FY1679;
RX PubMed=8533474; DOI=10.1002/yea.320111010;
RA van Dyck L., Pascual-Ahuir A., Purnelle B., Goffeau A.;
RT "An 8.2 kb DNA segment from chromosome XIV carries the RPD3 and PAS8 genes
RT as well as the Saccharomyces cerevisiae homologue of the thiamine-repressed
RT nmt1 gene and a chromosome III-duplicated gene for a putative aryl-alcohol
RT dehydrogenase.";
RL Yeast 11:987-991(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169873;
RA Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K.,
RA Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K.,
RA Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M.,
RA Beinhauer J.D., Boskovic J., Buitrago M.J., Bussereau F., Coster F.,
RA Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F.,
RA Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C.,
RA Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A.,
RA Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H.,
RA Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L.,
RA Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R.,
RA Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D.,
RA Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A.,
RA Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C.,
RA Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F.,
RA Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G.,
RA Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M.,
RA Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its
RT evolutionary implications.";
RL Nature 387:93-98(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
CC -!- INTERACTION:
CC P42884; P40073: SHO1; NbExp=2; IntAct=EBI-1994, EBI-18140;
CC -!- SIMILARITY: Belongs to the aldo/keto reductase family. Aldo/keto
CC reductase 2 subfamily. {ECO:0000305}.
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DR EMBL; X83226; CAA58227.1; -; Genomic_DNA.
DR EMBL; Z71607; CAA96264.1; -; Genomic_DNA.
DR EMBL; BK006947; DAA10232.1; -; Genomic_DNA.
DR PIR; S51335; S51335.
DR RefSeq; NP_014068.1; NM_001183169.1.
DR AlphaFoldDB; P42884; -.
DR SMR; P42884; -.
DR BioGRID; 35510; 42.
DR DIP; DIP-2146N; -.
DR IntAct; P42884; 3.
DR MINT; P42884; -.
DR STRING; 4932.YNL331C; -.
DR PaxDb; P42884; -.
DR PRIDE; P42884; -.
DR EnsemblFungi; YNL331C_mRNA; YNL331C; YNL331C.
DR GeneID; 855385; -.
DR KEGG; sce:YNL331C; -.
DR SGD; S000005275; AAD14.
DR VEuPathDB; FungiDB:YNL331C; -.
DR eggNOG; KOG1575; Eukaryota.
DR GeneTree; ENSGT00940000176306; -.
DR HOGENOM; CLU_023205_2_2_1; -.
DR InParanoid; P42884; -.
DR OMA; TTDYRSH; -.
DR BioCyc; YEAST:YNL331C-MON; -.
DR PRO; PR:P42884; -.
DR Proteomes; UP000002311; Chromosome XIV.
DR RNAct; P42884; protein.
DR GO; GO:0047681; F:aryl-alcohol dehydrogenase (NADP+) activity; IDA:SGD.
DR GO; GO:0006081; P:cellular aldehyde metabolic process; ISS:SGD.
DR Gene3D; 3.20.20.100; -; 1.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR SUPFAM; SSF51430; SSF51430; 1.
PE 1: Evidence at protein level;
KW NADP; Oxidoreductase; Reference proteome.
FT CHAIN 1..376
FT /note="Putative aryl-alcohol dehydrogenase AAD14"
FT /id="PRO_0000070369"
FT ACT_SITE 76
FT /note="Proton donor"
FT /evidence="ECO:0000250"
FT BINDING 151
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 236..246
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000250"
FT SITE 103
FT /note="Lowers pKa of active site Tyr"
FT /evidence="ECO:0000250"
SQ SEQUENCE 376 AA; 41991 MW; 2265406386938313 CRC64;
MTDLFKPLPE PPTELGRLRV LSKTAGIRVS PLILGGASIG DAWSGFMGSM NKEQAFELLD
AFYEAGGNCI DTANSYQNEE SEIWIGEWMA SRKLRDQIVI ATKFTGDYKK YEVGGGKSAN
YCGNHKRSLH VSVRDSLRKL QTDWIDILYI HWWDYMSSIE EVMDSLHILV QQGKVLYLGV
SDTPAWVVSA ANYYATSHGK TPFSVYQGKW NVLNRDFERD IIPMARHFGM ALAPWDVMGG
GRFQSKKAME ERKKNGEGLR TFVGGPEQTE LEVKISEALT KIAEEHGTES VTAIAIAYVR
SKAKNVFPLI GGRKIEHLKQ NIEALSIKLT PEQIEYLESI VPFDVGFPKS LIGDDPAVTK
KLSPLTSMSA RIAFDN
