ID   PTF1A_XENLA             Reviewed;         270 AA.
AC   Q4ZHW1;
DT   02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2005, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Pancreas transcription factor 1 subunit alpha;
DE   AltName: Full=Pancreas-specific transcription factor 1a;
DE   AltName: Full=Transcription factor Ptf1a/p48;
GN   Name=ptf1a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RA   Afelik S., Chen Y., Pieler T.;
RT   "Combined ectopic expression of Pdx1 and Ptf1a/p48 results in the stable
RT   conversion of posterior endoderm into endo- and exocrine pancreatic
RT   tissue.";
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor implicated in the cell fate
CC       determination in various organs. Binds to the E-box consensus sequence
CC       5'-CANNTG-3'. Acts together with pdx1 to induce the pancreatic lineage
CC       within the endoderm. Plays a central role in directing the
CC       differentiation of retinal progenitors towards horizontal and amacrine
CC       fates. {ECO:0000269|Ref.1}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
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DR   EMBL; DQ007931; AAY23360.1; -; mRNA.
DR   RefSeq; NP_001167491.1; NM_001174020.1.
DR   AlphaFoldDB; Q4ZHW1; -.
DR   SMR; Q4ZHW1; -.
DR   GeneID; 100381084; -.
DR   KEGG; xla:100381084; -.
DR   CTD; 100381084; -.
DR   Xenbase; XB-GENE-6466546; ptf1a.L.
DR   OMA; CYRDGAC; -.
DR   OrthoDB; 1269550at2759; -.
DR   Proteomes; UP000186698; Chromosome 6L.
DR   Bgee; 100381084; Expressed in pancreas and 13 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0005667; C:transcription regulator complex; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0031017; P:exocrine pancreas development; ISS:UniProtKB.
DR   GO; GO:0048699; P:generation of neurons; ISS:UniProtKB.
DR   GO; GO:0030902; P:hindbrain development; ISS:UniProtKB.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0048384; P:retinoic acid receptor signaling pathway; ISS:UniProtKB.
DR   GO; GO:0009888; P:tissue development; ISS:UniProtKB.
DR   Gene3D; 4.10.280.10; -; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   Pfam; PF00010; HLH; 1.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; SSF47459; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..270
FT                   /note="Pancreas transcription factor 1 subunit alpha"
FT                   /id="PRO_0000233147"
FT   DOMAIN          119..171
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
SQ   SEQUENCE   270 AA;  30522 MW;  E887B2A997F6A27E CRC64;
     METVLEQLAG LESFPSPYFD EDDFFTDHSS RDALDADDFL EDDVDFLAGQ IQDYYRDSRV
     LHTDDDYCDA GNFSFSSSSS GGFPYECGDG GCDLSPGMKG GSLVMKRRRR LRSDAEMQQL
     RQAANVRERR RMQSINDAFE GLRSHIPTLP YEKRLSKVDT LRLAIGYINF LSEMVQSDLP
     LRNPNSDSGN QPKKVIICHR GTRSPSPSDP DYGLPPLAGH SLSWTDEKQL RDQNVVRTAK
     VWTPEDPRKL NKSPFSNIEN EPPLTLCLDM