PTFC_BACAM
ID PTFC_BACAM Reviewed; 304 AA.
AC P41029;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 25-MAY-2022, entry version 85.
DE RecName: Full=Fructose permease IIC component;
DE AltName: Full=PTS system fructose-specific EIIC component;
DE Flags: Fragment;
GN Name=fruA;
OS Bacillus amyloliquefaciens (Bacillus velezensis).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC Bacillus amyloliquefaciens group.
OX NCBI_TaxID=1390;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 23844 / P;
RX PubMed=7578273; DOI=10.1016/0167-4889(95)00101-w;
RA Hoang V., Hofemeister J.;
RT "Bacillus amyloliquefaciens possesses a second type I signal peptidase with
RT extensive sequence similarity to other Bacillus SPases.";
RL Biochim. Biophys. Acta 1269:64-68(1995).
CC -!- FUNCTION: The phosphoenolpyruvate-dependent sugar phosphotransferase
CC system (PTS), a major carbohydrate active -transport system, catalyzes
CC the phosphorylation of incoming sugar substrates concomitant with their
CC translocation across the cell membrane. This system is involved in
CC fructose transport (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|PROSITE-
CC ProRule:PRU00427}; Multi-pass membrane protein {ECO:0000255|PROSITE-
CC ProRule:PRU00427}.
CC -!- DOMAIN: The EIIC domain forms the PTS system translocation channel and
CC contains the specific substrate-binding site.
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DR EMBL; Z33640; CAA83920.1; -; Genomic_DNA.
DR PIR; S59965; S59965.
DR AlphaFoldDB; P41029; -.
DR STRING; 692420.BAMF_1514; -.
DR PRIDE; P41029; -.
DR eggNOG; COG1299; Bacteria.
DR eggNOG; COG1445; Bacteria.
DR eggNOG; COG1762; Bacteria.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005351; F:carbohydrate:proton symporter activity; IEA:InterPro.
DR GO; GO:0008982; F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity; IEA:InterPro.
DR GO; GO:0009401; P:phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:UniProtKB-KW.
DR InterPro; IPR013014; PTS_EIIC_2.
DR InterPro; IPR006327; PTS_IIC_fruc.
DR TIGRFAMs; TIGR01427; PTS_IIC_fructo; 1.
DR PROSITE; PS51104; PTS_EIIC_TYPE_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Phosphotransferase system; Sugar transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN <1..304
FT /note="Fructose permease IIC component"
FT /id="PRO_0000186507"
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00427"
FT TRANSMEM 62..82
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00427"
FT TRANSMEM 98..118
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00427"
FT TRANSMEM 140..160
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00427"
FT TRANSMEM 181..201
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00427"
FT TRANSMEM 214..234
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00427"
FT TRANSMEM 238..258
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00427"
FT TRANSMEM 277..297
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00427"
FT DOMAIN <1..304
FT /note="PTS EIIC type-2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00427"
FT NON_TER 1
SQ SEQUENCE 304 AA; 31736 MW; 6FE90E921A7CF489 CRC64;
IHSADPKDPT YNTFAAALNF IGSDNALKLI VAVLAGFIAM SIADRPGFAP GMVGGFMATQ
ANAGFLGGLI AGFLAGYVVI LLKKLFVFIP QSLDGLKPVL IYPLLGIFIT GVLMQFVINT
PVAAFMNFLT NWLESLGTGN LVLMGIILGG MMAIDMGGPL NKAAFTFGIA MIDAGNYAPH
AAIMAGGMVP PLGIALATTF FRHKFSKRDR EAGITCYFMG AAFVTEGAIP FAAADLRVIP
AAVIGSAVAG GLTEFFRVTL PAPHGGVFVA FITNHPLLYL LSIVIGAIVT AVILGIIKKP
VEEK
