PTFC_BACSU
ID PTFC_BACSU Reviewed; 269 AA.
AC P26381;
DT 01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1992, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Fructose permease IIC component;
DE AltName: Full=EIIC-Fru;
DE AltName: Full=PTS system fructose-specific EIIC component;
DE AltName: Full=p28;
GN Name=levF; OrderedLocusNames=BSU27050;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RX PubMed=2117666; DOI=10.1016/0022-2836(90)90284-s;
RA Martin-Verstraete I., Debarbouille M., Klier A., Rapoport G.;
RT "Levanase operon of Bacillus subtilis includes a fructose-specific
RT phosphotransferase system regulating the expression of the operon.";
RL J. Mol. Biol. 214:657-671(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9141695; DOI=10.1099/00221287-143-4-1321;
RA Parro V., San Roman M., Galindo I., Purnelle B., Bolotin A., Sorokin A.,
RA Mellado R.P.;
RT "A 23911 bp region of the Bacillus subtilis genome comprising genes located
RT upstream and downstream of the lev operon.";
RL Microbiology 143:1321-1326(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
CC -!- FUNCTION: The phosphoenolpyruvate-dependent sugar phosphotransferase
CC system (PTS), a major carbohydrate active -transport system, catalyzes
CC the phosphorylation of incoming sugar substrates concomitant with their
CC translocation across the cell membrane. This system is involved in
CC fructose transport.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- DOMAIN: The EIIC domain forms the PTS system translocation channel and
CC contains the specific substrate-binding site.
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DR EMBL; X56098; CAA39579.1; -; Genomic_DNA.
DR EMBL; X92868; CAA63463.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB14647.1; -; Genomic_DNA.
DR PIR; S11400; S11400.
DR RefSeq; NP_390583.1; NC_000964.3.
DR RefSeq; WP_003229833.1; NZ_JNCM01000036.1.
DR AlphaFoldDB; P26381; -.
DR SMR; P26381; -.
DR STRING; 224308.BSU27050; -.
DR TCDB; 4.A.6.1.2; the pts mannose-fructose-sorbose (man) family.
DR PaxDb; P26381; -.
DR EnsemblBacteria; CAB14647; CAB14647; BSU_27050.
DR GeneID; 937602; -.
DR KEGG; bsu:BSU27050; -.
DR PATRIC; fig|224308.179.peg.2938; -.
DR eggNOG; COG3715; Bacteria.
DR InParanoid; P26381; -.
DR OMA; DWIHVSA; -.
DR PhylomeDB; P26381; -.
DR BioCyc; BSUB:BSU27050-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0009401; P:phosphoenolpyruvate-dependent sugar phosphotransferase system; IBA:GO_Central.
DR InterPro; IPR004700; PTS_IIC_man.
DR Pfam; PF03609; EII-Sor; 1.
DR TIGRFAMs; TIGR00822; EII-Sor; 1.
DR PROSITE; PS51106; PTS_EIIC_TYPE_4; 1.
PE 4: Predicted;
KW Cell membrane; Membrane; Phosphotransferase system; Reference proteome;
KW Sugar transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..269
FT /note="Fructose permease IIC component"
FT /id="PRO_0000186521"
FT TRANSMEM 2..22
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00429"
FT TRANSMEM 35..54
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00429"
FT TRANSMEM 64..86
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00429"
FT TRANSMEM 90..110
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00429"
FT TRANSMEM 149..169
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00429"
FT TRANSMEM 181..201
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00429"
FT TRANSMEM 206..226
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00429"
FT DOMAIN 1..234
FT /note="PTS EIIC type-4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00429"
SQ SEQUENCE 269 AA; 28019 MW; F275446BA2739281 CRC64;
MSSLQIILLL IIAAITGIAS VLDEGQTHRP LVACTLVGLV LGDLKTGIIL GGTLELMALG
WMNVGLAMAP DTAIASVIST ILVITADQGI GEGIAVAVAL AAAGQALTIF VRTITVFFIH
RADQYAKAGN IKGIEIMHIT AMVFQALRVM IPTLIVALIS VSAVQAFLGN IPDVITKGLQ
IGGGIIVVVG YAMVINMMNI PYLKPFFYIG FLLAAFTDFN LVGFGALGLC LALLYQQVMQ
KQSAHGAVAA ASDSGSVAVY DDDDDDLDA
