ID   PTF_ARTOC               Reviewed;         314 AA.
AC   C5FQT8;
DT   25-MAY-2022, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 43.
DE   RecName: Full=Aromatic prenyltransferase {ECO:0000303|PubMed:20351110};
DE            EC=2.5.1.- {ECO:0000305|PubMed:20351110};
GN   Name=ptf {ECO:0000303|PubMed:20351110}; ORFNames=MCYG_05060;
OS   Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Arthrodermataceae; Microsporum.
OX   NCBI_TaxID=554155;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4605 / CBS 113480;
RX   PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA   Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA   Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA   Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA   Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA   Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT   "Comparative genome analysis of Trichophyton rubrum and related
RT   dermatophytes reveals candidate genes involved in infection.";
RL   MBio 3:E259-E259(2012).
RN   [2]
RP   FUNCTION.
RX   PubMed=20351110; DOI=10.1074/jbc.m110.113720;
RA   Haug-Schifferdecker E., Arican D., Brueckner R., Heide L.;
RT   "A new group of aromatic prenyltransferases in fungi, catalyzing a 2,7-
RT   dihydroxynaphthalene 3-dimethylallyl-transferase reaction.";
RL   J. Biol. Chem. 285:16487-16494(2010).
CC   -!- FUNCTION: Prenyltransferase that attaches isoprenoid moieties to carbon
CC       atoms of aromatic substrates in an enzyme-catalyzed Friedel-Crafts
CC       reaction. {ECO:0000269|PubMed:20351110}.
CC   -!- MISCELLANEOUS: The gene is not located within a recognizable secondary
CC       metabolic gene cluster. {ECO:0000269|PubMed:20351110}.
CC   -!- SIMILARITY: Belongs to the aromatic prenyltransferase family.
CC       {ECO:0000305}.
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DR   EMBL; DS995704; EEQ32241.1; -; Genomic_DNA.
DR   RefSeq; XP_002847323.1; XM_002847277.1.
DR   EnsemblFungi; EEQ32241; EEQ32241; MCYG_05060.
DR   GeneID; 9226178; -.
DR   eggNOG; ENOG502SMTG; Eukaryota.
DR   HOGENOM; CLU_057184_0_0_1; -.
DR   OMA; ALNYRFY; -.
DR   OrthoDB; 971902at2759; -.
DR   Proteomes; UP000002035; Unassembled WGS sequence.
DR   GO; GO:0004659; F:prenyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR   CDD; cd13931; PT-CloQ_NphB; 1.
DR   InterPro; IPR033964; Aro_prenylTrfase.
DR   InterPro; IPR020965; Prenyltransferase_CloQ.
DR   InterPro; IPR036239; PrenylTrfase-like_sf.
DR   Pfam; PF11468; PTase_Orf2; 1.
DR   SFLD; SFLDS00036; Aromatic_Prenyltransferase; 1.
DR   SFLD; SFLDG01163; II; 1.
DR   SUPFAM; SSF143492; SSF143492; 1.
PE   3: Inferred from homology;
KW   Prenyltransferase; Reference proteome; Transferase.
FT   CHAIN           1..314
FT                   /note="Aromatic prenyltransferase"
FT                   /id="PRO_0000455464"
SQ   SEQUENCE   314 AA;  35052 MW;  F45FF9D97F547917 CRC64;
     MPASAPQNST TFDSARFLDD YKKTADALGA PYNESIVART LNSFGNCFNE GTVIWRSTSR
     PNDKLNYRFY LRDRVDTVAL AIKAGYIEES HPMARLVTCW SNLFDGETVQ WCDLDPEEGV
     AKTWIFMKTQ RSIDNILDAA EVSDCVRAHR ATFHSLGLKL VHFAAVDYHG GTLNIYFTVP
     GPISEAQAAA YTNLSGCKPP TPDEFADLRK YLPTQRFVFA ATIDYTTGKI KRVAFYALNV
     PGSELPETMN DRLRKFFADA PSYDKQQTKN IAWSYGNGDS KYMKGLGEEC EESRAGTFGP
     DVGGCESFLL LLRL