ID   PTF_TALMQ               Reviewed;         364 AA.
AC   B6Q506;
DT   25-MAY-2022, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 1.
DT   25-MAY-2022, entry version 44.
DE   RecName: Full=Aromatic prenyltransferase {ECO:0000303|PubMed:20351110};
DE            EC=2.5.1.- {ECO:0000305|PubMed:20351110};
DE   Flags: Precursor;
GN   Name=ptf {ECO:0000303|PubMed:20351110}; ORFNames=PMAA_022320;
OS   Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)
OS   (Penicillium marneffei).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC   Talaromyces sect. Talaromyces.
OX   NCBI_TaxID=441960;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 18224 / CBS 334.59 / QM 7333;
RX   PubMed=25676766; DOI=10.1128/genomea.01559-14;
RA   Nierman W.C., Fedorova-Abrams N.D., Andrianopoulos A.;
RT   "Genome sequence of the AIDS-associated pathogen Penicillium marneffei
RT   (ATCC18224) and its near taxonomic relative Talaromyces stipitatus
RT   (ATCC10500).";
RL   Genome Announc. 3:E0155914-E0155914(2015).
RN   [2]
RP   FUNCTION.
RX   PubMed=20351110; DOI=10.1074/jbc.m110.113720;
RA   Haug-Schifferdecker E., Arican D., Brueckner R., Heide L.;
RT   "A new group of aromatic prenyltransferases in fungi, catalyzing a 2,7-
RT   dihydroxynaphthalene 3-dimethylallyl-transferase reaction.";
RL   J. Biol. Chem. 285:16487-16494(2010).
CC   -!- FUNCTION: Prenyltransferase that attaches isoprenoid moieties to carbon
CC       atoms of aromatic substrates in an enzyme-catalyzed Friedel-Crafts
CC       reaction. {ECO:0000269|PubMed:20351110}.
CC   -!- MISCELLANEOUS: The gene is not located within a recognizable secondary
CC       metabolic gene cluster. {ECO:0000269|PubMed:20351110}.
CC   -!- SIMILARITY: Belongs to the aromatic prenyltransferase family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DS995899; EEA27349.1; -; Genomic_DNA.
DR   RefSeq; XP_002143864.1; XM_002143828.1.
DR   EnsemblFungi; EEA27349; EEA27349; PMAA_022320.
DR   GeneID; 7021690; -.
DR   KEGG; tmf:PMAA_022320; -.
DR   VEuPathDB; FungiDB:PMAA_022320; -.
DR   HOGENOM; CLU_057184_0_0_1; -.
DR   OrthoDB; 971902at2759; -.
DR   PhylomeDB; B6Q506; -.
DR   Proteomes; UP000001294; Unassembled WGS sequence.
DR   GO; GO:0004659; F:prenyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR   CDD; cd13931; PT-CloQ_NphB; 1.
DR   InterPro; IPR033964; Aro_prenylTrfase.
DR   InterPro; IPR020965; Prenyltransferase_CloQ.
DR   InterPro; IPR036239; PrenylTrfase-like_sf.
DR   Pfam; PF11468; PTase_Orf2; 1.
DR   SFLD; SFLDS00036; Aromatic_Prenyltransferase; 1.
DR   SFLD; SFLDG01163; II; 1.
DR   SUPFAM; SSF143492; SSF143492; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Prenyltransferase; Reference proteome; Signal; Transferase.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..364
FT                   /note="Aromatic prenyltransferase"
FT                   /id="PRO_5002847864"
FT   CARBOHYD        142
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        337
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ   SEQUENCE   364 AA;  40606 MW;  AF591D18E5B92DD0 CRC64;
     MDRNQWTLAL MALMRFAHRA FINPVSPLPK FSRLAFTQGA SRLYATLHVD AGLQDNVVDK
     AAKPYLSRRL KFNAEHFKQD VSELCTTLNA DYNEGVMNAV LNTYKENFER GAVLWKATSK
     EDGVAFRFYE RKKVDVVGPA INNSLISGNH GMIPLITSWA NFKKNAIASC DFDPAKGLCK
     TWIWLGGRHP TRDLLVAPNV PGTIRSLERK LISAGLHTVR HAAVDWRSST VNLYFWVPRP
     LTLPVVNTLI TLPGTPPINE EKLTLMKPFF KPNGFTFATT IDTATGKFKR VSFYALRLDG
     NNLPIMGDQL ATFFKDAPSN DKTEMNIVAW SFAGGSNGSS NYIKGERSYI GDLEQVLDAW
     GSPI