ID   PTG3L_HUMAN             Reviewed;         166 AA.
AC   E9PB15; B9A003;
DT   05-SEP-2012, integrated into UniProtKB/Swiss-Prot.
DT   05-APR-2011, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Putative protein PTGES3L {ECO:0000305};
DE   AltName: Full=Prostaglandin E synthase 3-like;
GN   Name=PTGES3L {ECO:0000312|HGNC:HGNC:43943};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA   Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA   Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA   LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA   Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA   Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA   Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT   human lineage.";
RL   Nature 440:1045-1049(2006).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=5;
CC       Name=1;
CC         IsoId=E9PB15-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9BTE6-2; Sequence=External;
CC       Name=3;
CC         IsoId=Q9BTE6-3; Sequence=External;
CC       Name=4;
CC         IsoId=E9PB15-2; Sequence=VSP_060623, VSP_060624;
CC       Name=5;
CC         IsoId=E9PB15-3; Sequence=VSP_060622;
CC   -!- SIMILARITY: Belongs to the p23/wos2 family. {ECO:0000305}.
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DR   EMBL; AC055866; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001136125.1; NM_001142653.1. [E9PB15-3]
DR   RefSeq; NP_001136126.1; NM_001142654.1.
DR   AlphaFoldDB; E9PB15; -.
DR   SMR; E9PB15; -.
DR   BioGRID; 3190352; 2.
DR   STRING; 9606.ENSP00000386902; -.
DR   iPTMnet; E9PB15; -.
DR   PhosphoSitePlus; E9PB15; -.
DR   BioMuta; PTGES3L; -.
DR   MassIVE; E9PB15; -.
DR   PaxDb; E9PB15; -.
DR   PeptideAtlas; E9PB15; -.
DR   PRIDE; E9PB15; -.
DR   ProteomicsDB; 19122; -. [E9PB15-1]
DR   ProteomicsDB; 7473; -.
DR   DNASU; 80755; -.
DR   Ensembl; ENST00000451885.3; ENSP00000404440.3; ENSG00000267060.7. [E9PB15-3]
DR   GeneID; 100885848; -.
DR   KEGG; hsa:100885848; -.
DR   UCSC; uc002ich.4; human.
DR   CTD; 100885848; -.
DR   GeneCards; PTGES3L; -.
DR   HGNC; HGNC:43943; PTGES3L.
DR   neXtProt; NX_E9PB15; -.
DR   OpenTargets; ENSG00000267060; -.
DR   PharmGKB; PA142670464; -.
DR   VEuPathDB; HostDB:ENSG00000267060; -.
DR   eggNOG; KOG2105; Eukaryota.
DR   eggNOG; KOG3158; Eukaryota.
DR   GeneTree; ENSGT00940000163448; -.
DR   InParanoid; E9PB15; -.
DR   OrthoDB; 1461729at2759; -.
DR   PhylomeDB; E9PB15; -.
DR   PathwayCommons; E9PB15; -.
DR   BioGRID-ORCS; 100885848; 11 hits in 998 CRISPR screens.
DR   GenomeRNAi; 100885848; -.
DR   Pharos; E9PB15; Tdark.
DR   PRO; PR:E9PB15; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   RNAct; E9PB15; protein.
DR   Bgee; ENSG00000267060; Expressed in hindlimb stylopod muscle and 105 other tissues.
DR   ExpressionAtlas; E9PB15; baseline and differential.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0051087; F:chaperone binding; IBA:GO_Central.
DR   GO; GO:0051879; F:Hsp90 protein binding; IBA:GO_Central.
DR   GO; GO:0051131; P:chaperone-mediated protein complex assembly; IBA:GO_Central.
DR   GO; GO:0006457; P:protein folding; IBA:GO_Central.
DR   Gene3D; 2.60.40.790; -; 1.
DR   InterPro; IPR007052; CS_dom.
DR   InterPro; IPR008978; HSP20-like_chaperone.
DR   InterPro; IPR045250; p23-like.
DR   PANTHER; PTHR22932; PTHR22932; 2.
DR   SUPFAM; SSF49764; SSF49764; 1.
DR   PROSITE; PS51203; CS; 1.
PE   3: Inferred from homology;
KW   Alternative splicing; Reference proteome.
FT   CHAIN           1..166
FT                   /note="Putative protein PTGES3L"
FT                   /id="PRO_0000418440"
FT   DOMAIN          46..154
FT                   /note="CS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00547"
FT   REGION          142..166
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..43
FT                   /note="Missing (in isoform 5)"
FT                   /id="VSP_060622"
FT   VAR_SEQ         47..84
FT                   /note="Missing (in isoform 4)"
FT                   /id="VSP_060623"
FT   VAR_SEQ         105
FT                   /note="S -> SKDSQDKRSSRSITCFVRKWKEKVAWPRLTKEDI (in isoform
FT                   4)"
FT                   /id="VSP_060624"
SQ   SEQUENCE   166 AA;  19074 MW;  F960941BA0FC90C1 CRC64;
     MFSLPLNCSP DHIRRGSCWG RPQDLKIAAP AWNSKCHPGA GAAMARQHAR TLWYDRPRYV
     FMEFCVEDST DVHVLIEDHR IVFSCKNADG VELYNEIEFY AKVNSKPVWL SVDFDNWRDW
     EGDEEMELAH VEHYAELLKK VSTKRPPPAM DDLDDDSDSA DDATSN