ID   AAD15_YEAST             Reviewed;         143 AA.
AC   Q08361; D6W1Q4;
DT   25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=Putative aryl-alcohol dehydrogenase AAD15;
DE            EC=1.1.1.-;
GN   Name=AAD15; OrderedLocusNames=YOL165C;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169874;
RA   Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J.,
RA   Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A.,
RA   Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B.,
RA   Dang V.-D., de Haan M., Delius H., Durand P., Fairhead C., Feldmann H.,
RA   Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E.,
RA   Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U.,
RA   Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B.,
RA   Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A.,
RA   Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C.,
RA   Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G.,
RA   Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B.,
RA   Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B.,
RA   Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F.,
RA   Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E.,
RA   Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I.,
RA   Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H.,
RA   Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV.";
RL   Nature 387:98-102(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   NOMENCLATURE.
RX   PubMed=10581269; DOI=10.1093/genetics/153.4.1591;
RA   Delneri D., Gardner D.C.J., Oliver S.G.;
RT   "Analysis of the seven-member AAD gene set demonstrates that genetic
RT   redundancy in yeast may be more apparent than real.";
RL   Genetics 153:1591-1600(1999).
CC   -!- FUNCTION: Putative aryl-alcohol dehydrogenase. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the aldo/keto reductase family. Aldo/keto
CC       reductase 2 subfamily. {ECO:0000305}.
CC   -!- CAUTION: In contrast to other aldo/keto reductase 2 proteins, it lacks
CC       the N-terminal half which contains the active site. It is therefore
CC       unlikely that it acts as a functional oxydoreductase. {ECO:0000305}.
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DR   EMBL; Z74907; CAA99187.1; -; Genomic_DNA.
DR   EMBL; BK006948; DAA10620.1; -; Genomic_DNA.
DR   PIR; S66864; S66864.
DR   RefSeq; NP_014477.1; NM_001183418.1.
DR   AlphaFoldDB; Q08361; -.
DR   SMR; Q08361; -.
DR   BioGRID; 34253; 19.
DR   IntAct; Q08361; 1.
DR   STRING; 4932.YOL165C; -.
DR   PaxDb; Q08361; -.
DR   PRIDE; Q08361; -.
DR   TopDownProteomics; Q08361; -.
DR   EnsemblFungi; YOL165C_mRNA; YOL165C; YOL165C.
DR   GeneID; 853999; -.
DR   KEGG; sce:YOL165C; -.
DR   SGD; S000005525; AAD15.
DR   VEuPathDB; FungiDB:YOL165C; -.
DR   eggNOG; KOG1575; Eukaryota.
DR   GeneTree; ENSGT00940000176306; -.
DR   HOGENOM; CLU_138066_1_0_1; -.
DR   InParanoid; Q08361; -.
DR   OMA; HIDAPPN; -.
DR   BioCyc; YEAST:YOL165C-MON; -.
DR   PRO; PR:Q08361; -.
DR   Proteomes; UP000002311; Chromosome XV.
DR   RNAct; Q08361; protein.
DR   GO; GO:0047681; F:aryl-alcohol dehydrogenase (NADP+) activity; ISS:SGD.
DR   GO; GO:0006081; P:cellular aldehyde metabolic process; ISS:SGD.
DR   Gene3D; 3.20.20.100; -; 1.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   SUPFAM; SSF51430; SSF51430; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase; Reference proteome.
FT   CHAIN           1..143
FT                   /note="Putative aryl-alcohol dehydrogenase AAD15"
FT                   /id="PRO_0000070370"
SQ   SEQUENCE   143 AA;  15722 MW;  B1D8F0399364F354 CRC64;
     MARHFGMALA PWDVMGGGRF QSKKAMEERR KNGECIRSFV GASEQTDAEI KISEALAKVA
     EEHGTESVTA IAIAYVRSKA KNVFPSVEGG KIEDLKENIK ALSIDLTPDN IKYLENVVPF
     DIGFPNTFIV LNSLTQKYGT NNV