PTH2_CAEEL
ID PTH2_CAEEL Reviewed; 316 AA.
AC O76387;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Probable peptidyl-tRNA hydrolase 2;
DE Short=PTH 2;
DE EC=3.1.1.29;
GN ORFNames=C24G6.8;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: The natural substrate for this enzyme may be peptidyl-tRNAs
CC which drop off the ribosome during protein synthesis. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-
CC amino acid + H(+); Xref=Rhea:RHEA:54448, Rhea:RHEA-COMP:10123,
CC Rhea:RHEA-COMP:13883, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:59874, ChEBI:CHEBI:78442, ChEBI:CHEBI:138191;
CC EC=3.1.1.29;
CC -!- SIMILARITY: Belongs to the PTH2 family. {ECO:0000305}.
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DR EMBL; FO080610; CCD65135.1; -; Genomic_DNA.
DR PIR; T33180; T33180.
DR RefSeq; NP_504461.1; NM_072060.4.
DR AlphaFoldDB; O76387; -.
DR SMR; O76387; -.
DR BioGRID; 43986; 1.
DR DIP; DIP-59880N; -.
DR IntAct; O76387; 2.
DR STRING; 6239.C24G6.8.1; -.
DR iPTMnet; O76387; -.
DR EPD; O76387; -.
DR PaxDb; O76387; -.
DR PeptideAtlas; O76387; -.
DR EnsemblMetazoa; C24G6.8.1; C24G6.8.1; WBGene00016062.
DR UCSC; C24G6.8.1; c. elegans.
DR WormBase; C24G6.8; CE17464; WBGene00016062; -.
DR eggNOG; KOG3282; Eukaryota.
DR GeneTree; ENSGT00940000165995; -.
DR HOGENOM; CLU_053028_0_0_1; -.
DR InParanoid; O76387; -.
DR OMA; SERIPDI; -.
DR OrthoDB; 1074302at2759; -.
DR PhylomeDB; O76387; -.
DR PRO; PR:O76387; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00016062; Expressed in germ line (C elegans) and 4 other tissues.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0004045; F:aminoacyl-tRNA hydrolase activity; IBA:GO_Central.
DR CDD; cd02430; PTH2; 1.
DR Gene3D; 3.40.1490.10; -; 1.
DR InterPro; IPR023476; Pep_tRNA_hydro_II_dom_sf.
DR InterPro; IPR002833; PTH2.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR009060; UBA-like_sf.
DR PANTHER; PTHR12649; PTHR12649; 1.
DR Pfam; PF01981; PTH2; 1.
DR Pfam; PF00627; UBA; 1.
DR SUPFAM; SSF102462; SSF102462; 1.
DR SUPFAM; SSF46934; SSF46934; 1.
DR TIGRFAMs; TIGR00283; arch_pth2; 1.
DR PROSITE; PS50030; UBA; 1.
PE 3: Inferred from homology;
KW Hydrolase; Reference proteome.
FT CHAIN 1..316
FT /note="Probable peptidyl-tRNA hydrolase 2"
FT /id="PRO_0000120283"
FT DOMAIN 128..169
FT /note="UBA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00212"
FT REGION 1..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 170..193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..57
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 82..125
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 316 AA; 33689 MW; 20E4FA3D52B4EFB0 CRC64;
MSENIPDIDP NELLPNAPGQ HQDLGVDNPP EPDNASIRAE RGSPTPSSVT VDNAPSLPDR
SFSHLPINDP FSGEIPEVPI PSSAISISSQ ALSDPVPTPS DTSRPGILRN DEQGSTSSHP
VDPQEPNEVN NEYLAHLLDL GFDEYTAVLA LKRTNSAGVE QAVAWIVERS NESDFDEDSS
SSENEADEEM GAVQSVAGRT HKMVLVANMS LKMGTGKIAA QVGHATLGVY RQAMNSENGQ
NAIAAWTRHG QVKIVVKGQS TEQLMDLCKV AKDAGCYYYL VQDAGYTQIP AGSRTVLGIF
GTVEQVDSVT GGLKLL
