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PTHB1_CAEEL
ID   PTHB1_CAEEL             Reviewed;         744 AA.
AC   O01514;
DT   09-DEC-2015, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2012, sequence version 5.
DT   03-AUG-2022, entry version 128.
DE   RecName: Full=Protein pthb1 homolog {ECO:0000305};
DE   AltName: Full=Bardet-Biedl syndrome 9 protein homolog {ECO:0000312|WormBase:C48B6.8};
GN   Name=bbs-9 {ECO:0000312|WormBase:C48B6.8};
GN   ORFNames=C48B6.8 {ECO:0000312|WormBase:C48B6.8};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN   [1] {ECO:0000312|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2] {ECO:0000305}
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=22022287; DOI=10.1371/journal.pgen.1002335;
RA   Mok C.A., Healey M.P., Shekhar T., Leroux M.R., Heon E., Zhen M.;
RT   "Mutations in a guanylate cyclase GCY-35/GCY-36 modify Bardet-Biedl
RT   syndrome-associated phenotypes in Caenorhabditis elegans.";
RL   PLoS Genet. 7:E1002335-E1002335(2011).
RN   [3] {ECO:0000305}
RP   FUNCTION, INTERACTION WITH BBS-1, AND DISRUPTION PHENOTYPE.
RX   PubMed=22922713; DOI=10.1038/ncb2560;
RA   Wei Q., Zhang Y., Li Y., Zhang Q., Ling K., Hu J.;
RT   "The BBSome controls IFT assembly and turnaround in cilia.";
RL   Nat. Cell Biol. 14:950-957(2012).
RN   [4]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=30014846; DOI=10.7554/elife.36833;
RA   Hao Y., Yang W., Ren J., Hall Q., Zhang Y., Kaplan J.M.;
RT   "Thioredoxin shapes the C. elegans sensory response to Pseudomonas produced
RT   nitric oxide.";
RL   Elife 7:0-0(2018).
CC   -!- FUNCTION: Component of the BBSome complex (By similarity). The BBSome
CC       complex is thought to function as a coat complex required for sorting
CC       of specific membrane proteins to the primary cilia (By similarity). The
CC       BBSome complex is required for ciliogenesis but is dispensable for
CC       centriolar satellite function (By similarity). Required for proper
CC       BBSome complex assembly and its ciliary localization (PubMed:22922713).
CC       Required for cilia biogenesis and both the assembly and movement of
CC       intraflagellar transport proteins along the ciliary axoneme
CC       (PubMed:22022287, PubMed:22922713). In ciliated sensory neurons,
CC       required for the sensation of nitric oxide and avoidance of NO-
CC       producing organisms like P.aeruginosa (PubMed:30014846).
CC       {ECO:0000250|UniProtKB:Q3SYG4, ECO:0000269|PubMed:22022287,
CC       ECO:0000269|PubMed:22922713, ECO:0000269|PubMed:30014846}.
CC   -!- SUBUNIT: Part of BBSome complex, that contains bbs-1, bbs-2, bbs-4,
CC       bbs-5, osm-12, bbs-8/ttc-8 and bbs-9 (By similarity). Interacts with
CC       bbs-1 (PubMed:22922713). {ECO:0000250|UniProtKB:Q3SYG4,
CC       ECO:0000269|PubMed:22922713}.
CC   -!- DISRUPTION PHENOTYPE: Mutants have normal body morphology, but with
CC       reduced body length and width, delayed larval development and decreased
CC       roaming movements (PubMed:22022287). Defective cilia structure and
CC       function characterized by an increased accumulation and mislocalization
CC       of intraflagellar transport proteins and impaired movement of
CC       intraflagellar transport proteins along the ciliary axoneme
CC       (PubMed:22922713). Disrupted assembly of the BBSome complex at the base
CC       of the cilia (PubMed:22922713). Defective avoidance of nitric oxide and
CC       P.aeruginosa (PubMed:30014846). {ECO:0000269|PubMed:22022287,
CC       ECO:0000269|PubMed:22922713, ECO:0000269|PubMed:30014846}.
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DR   EMBL; BX284601; CCD67585.2; -; Genomic_DNA.
DR   RefSeq; NP_491973.4; NM_059572.4.
DR   AlphaFoldDB; O01514; -.
DR   SMR; O01514; -.
DR   ComplexPortal; CPX-428; BBSome complex.
DR   DIP; DIP-61856N; -.
DR   IntAct; O01514; 2.
DR   STRING; 6239.C48B6.8; -.
DR   EPD; O01514; -.
DR   PaxDb; O01514; -.
DR   EnsemblMetazoa; C48B6.8.1; C48B6.8.1; WBGene00016744.
DR   GeneID; 183572; -.
DR   KEGG; cel:CELE_C48B6.8; -.
DR   UCSC; C48B6.8; c. elegans.
DR   CTD; 183572; -.
DR   WormBase; C48B6.8; CE46977; WBGene00016744; bbs-9.
DR   eggNOG; KOG3679; Eukaryota.
DR   GeneTree; ENSGT00390000000803; -.
DR   HOGENOM; CLU_019585_0_0_1; -.
DR   InParanoid; O01514; -.
DR   OMA; VPVEDWT; -.
DR   OrthoDB; 332152at2759; -.
DR   PhylomeDB; O01514; -.
DR   Reactome; R-CEL-5620922; BBSome-mediated cargo-targeting to cilium.
DR   PRO; PR:O01514; -.
DR   Proteomes; UP000001940; Chromosome I.
DR   Bgee; WBGene00016744; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR   GO; GO:0034464; C:BBSome; IBA:GO_Central.
DR   GO; GO:0036064; C:ciliary basal body; IDA:MGI.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0060271; P:cilium assembly; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR028074; PHTB1_C_dom.
DR   InterPro; IPR028073; PHTB1_N_dom.
DR   InterPro; IPR026511; PTHB1.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR20991; PTHR20991; 1.
DR   Pfam; PF14728; PHTB1_C; 1.
DR   Pfam; PF14727; PHTB1_N; 1.
DR   SUPFAM; SSF50978; SSF50978; 1.
PE   1: Evidence at protein level;
KW   Cilium biogenesis/degradation; Protein transport; Reference proteome;
KW   Transport.
FT   CHAIN           1..744
FT                   /note="Protein pthb1 homolog"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000435000"
FT   REGION          722..744
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        722..737
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   744 AA;  83047 MW;  7EC492B884500D7D CRC64;
     MSLFRLVEWV SQTIPNTSTI LNASFFQDRE QLVIGGENGQ ITISDPGFRD TNAHVLCTTE
     TKYAILQMAS DNFLPSMNNI LAVLSPTKLT YYKVHFASPD ETLASLDEIF SHSFSTSAWN
     MCVIPIEEST PQILVQSIDC KLSLFQGDQC VFSMVPLRAL QPGPIGYCQT TQTLFVANNG
     FLAAIKFSLM SSGSQKKINY DWSFNLGDTA IQMKVTEGSK PTTIVLCRRH VSAFNATGSV
     VWQIRLEAVG MAMCLYRSLL INNTQFNRLI VSTSDDTLLI FQDNKLVWNC NAQMSPVALL
     VCSYNKSYEN TITMMAPDGK VVVGYLGTEP NLYRLPEDKV IVNYAERMEE YKRMEQKIKE
     SDAAGGAIKR KEGIQMKLSI GEIGKRTIEP NAASNAPYCN LIVEFSEVQN VSKLHINILS
     ECASPSKQVI LNVGTSKSTA SIEIPFYVGS KKSPTSNKVT IAAHCAFTQL TVTKSIDLPF
     KVLFEESQID RNAKYKVTID TAGSVMPLNK LFSEFESENP QAIGFSLHGS DKTVSVFAAN
     KSNRYRIQSE HISLLQITSR ELVKRIAESA PGIEIGGVIP FEYMRETLDE IQELQTKKKE
     DSKKIDCRTK EVRAIEALSL NSCKTGNMGN LPSLDALFDK SYRELLDAMD SYNSLTAKIE
     NQKASLNSLF QLAADLSKLS KVDTILNGSF WANTQQSLRD RLRWAVKTDR GNEMTMIEKL
     CEHSPKELPK IREEEEEEEQ QVTA
 
 
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