ID   PTHB1_XENLA             Reviewed;         849 AA.
AC   Q6AX60;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=Protein PTHB1;
DE   AltName: Full=Bardet-Biedl syndrome 9 protein homolog;
DE   AltName: Full=Parathyroid hormone-responsive B1 gene protein homolog;
GN   Name=bbs9; Synonyms=pthb1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for ciliogenesis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane {ECO:0000250}.
CC       Cytoplasm, cytoskeleton, microtubule organizing center, centrosome,
CC       centriolar satellite {ECO:0000250}.
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DR   EMBL; BC079742; AAH79742.1; -; mRNA.
DR   RefSeq; NP_001087412.1; NM_001093943.1.
DR   AlphaFoldDB; Q6AX60; -.
DR   SMR; Q6AX60; -.
DR   GeneID; 447236; -.
DR   KEGG; xla:447236; -.
DR   CTD; 447236; -.
DR   Xenbase; XB-GENE-954602; bbs9.L.
DR   Proteomes; UP000186698; Chromosome 6L.
DR   Bgee; 447236; Expressed in testis and 19 other tissues.
DR   GO; GO:0034464; C:BBSome; IEA:InterPro.
DR   GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR   InterPro; IPR028074; PHTB1_C_dom.
DR   InterPro; IPR028073; PHTB1_N_dom.
DR   InterPro; IPR026511; PTHB1.
DR   PANTHER; PTHR20991; PTHR20991; 1.
DR   Pfam; PF14728; PHTB1_C; 1.
DR   Pfam; PF14727; PHTB1_N; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cell projection; Cilium; Cytoplasm; Cytoskeleton; Membrane;
KW   Reference proteome.
FT   CHAIN           1..849
FT                   /note="Protein PTHB1"
FT                   /id="PRO_0000235271"
FT   REGION          1..407
FT                   /note="Seven-bladed beta-propeller"
FT                   /evidence="ECO:0000250|UniProtKB:Q3SYG4"
FT   REGION          825..849
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        826..849
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   SITE            141
FT                   /note="Critical for protein stability"
FT                   /evidence="ECO:0000250|UniProtKB:Q3SYG4"
SQ   SEQUENCE   849 AA;  94844 MW;  3B6B3C79AF518728 CRC64;
     MSLFKARDWW SASLGEKEEF DQGCLCVADV DNSGTAHDKI IVGSFSGYLR IFSPHPLKPG
     DGMQAEDLLL EVQLRDPVLQ VEVGKFVSGT EILHLAVLHP RKLCVYSVSG TLGNVEHGNQ
     YQMKLMYEHN LQRTACSMTH GPFGGVKGRD LICIQSMDGM LMFFEQESYA FGRYLPGFLL
     PGPLSYSPKT DSFVTVSSSR QVESYKYQVL AVATDADSRK ENEQQKMGAG KKVVADWILN
     IGEQALDISI VSFNQTSFSI FVLGERNFFC LKESGQIRFM KKLDYSPSCF HPYSSVNDGT
     INTLVGNHNN MLLVYQDVTL KWAAQLSQTP VAVKVANFRD LKGVIVTLSE SGQLQCSYLG
     TDPSLFQVPK VESRDINYED LDVEMKELQR IIKEATKTQD ILPKMEKDDD LTLVATVLPD
     LDSVSQAVDG EVESEVIPSV SVKLCVRSRL TLQKAVLLIS TPAPLALTQD QFIFDSLEPG
     VSKTASASVF LKGNYPPADL EGSAVVSYSK PTELNPEGVP RIVQCKFRLP LKLVCFPVQP
     SKVANHKLTI DTNKPPVNLI NLFPEFIDQV EEDQVSVVGF QLLAGQKVTL LASKTSQRYR
     IQSEQFEDLW LITREFILRF QDYFLKQGIK DFTCSFSGPV PLQEYFELID QHFELRLNGE
     KYEALLSERA VQFRAIQRLL LTRFKDKTPT PLQNLDTLLD GTYRQVIGIA DAAEELQRNL
     FRAFTRLKSA TQLVILLIGL WQKLNKEQIA ILEGTFLPLL KDGQELGWEE SVDAALSHLL
     RTCLSKSSKE QALNLTSHLS IPKDTSRLKK HITLLCERMS KGGRLSLSAD SGSQQAAEMQ
     GTPINPSVS