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PTHC_CLOB8
ID   PTHC_CLOB8              Reviewed;         182 AA.
AC   O32332; A6LQ94;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=PTS system glucitol/sorbitol-specific EIIC component {ECO:0000250|UniProtKB:P56579};
DE   AltName: Full=EIIC-Gut {ECO:0000250|UniProtKB:P56579};
DE   AltName: Full=Glucitol/sorbitol permease IIC component {ECO:0000250|UniProtKB:P56579};
GN   Name=srlA; Synonyms=gutA1; OrderedLocusNames=Cbei_0336;
OS   Clostridium beijerinckii (strain ATCC 51743 / NCIMB 8052) (Clostridium
OS   acetobutylicum).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=290402;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND INDUCTION.
RX   PubMed=9572925; DOI=10.1128/aem.64.5.1612-1619.1998;
RA   Tangney M., Brehm J.K., Minton N.P., Mitchell W.J.;
RT   "A gene system for glucitol transport and metabolism in Clostridium
RT   beijerinckii NCIMB 8052.";
RL   Appl. Environ. Microbiol. 64:1612-1619(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51743 / NCIMB 8052;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Sims D., Brettin T., Bruce D., Tapia R., Brainard J., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Bennet G.,
RA   Cann I., Chen J.-S., Contreras A.L., Jones D., Kashket E., Mitchell W.,
RA   Stoddard S., Schwarz W., Qureshi N., Young M., Shi Z., Ezeji T., White B.,
RA   Blaschek H., Richardson P.;
RT   "Complete sequence of Clostridium beijerinckii NCIMB 8052.";
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The phosphoenolpyruvate-dependent sugar phosphotransferase
CC       system (PTS), a major carbohydrate active transport system, catalyzes
CC       the phosphorylation of incoming sugar substrates concomitant with their
CC       translocation across the cell membrane. The enzyme II complex composed
CC       of SrlA, SrlB and SrlE is involved in glucitol/sorbitol transport.
CC       {ECO:0000305|PubMed:9572925}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|PROSITE-
CC       ProRule:PRU00430}; Multi-pass membrane protein {ECO:0000255|PROSITE-
CC       ProRule:PRU00430}.
CC   -!- INDUCTION: Activated by sorbitol and repressed by glucose.
CC       {ECO:0000269|PubMed:9572925}.
CC   -!- DOMAIN: The EIIC domain forms the PTS system translocation channel and
CC       contains the specific substrate-binding site. {ECO:0000255|PROSITE-
CC       ProRule:PRU00430}.
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DR   EMBL; AJ002527; CAA05513.1; -; Genomic_DNA.
DR   EMBL; CP000721; ABR32524.1; -; Genomic_DNA.
DR   RefSeq; WP_011967685.1; NC_009617.1.
DR   AlphaFoldDB; O32332; -.
DR   STRING; 290402.Cbei_0336; -.
DR   TCDB; 4.A.4.1.2; the pts glucitol (gut) family.
DR   EnsemblBacteria; ABR32524; ABR32524; Cbei_0336.
DR   GeneID; 66343213; -.
DR   KEGG; cbe:Cbei_0336; -.
DR   eggNOG; COG3730; Bacteria.
DR   HOGENOM; CLU_093147_0_0_9; -.
DR   OMA; HINPGEY; -.
DR   OrthoDB; 1287700at2; -.
DR   Proteomes; UP000000565; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0009401; P:phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:UniProtKB-KW.
DR   InterPro; IPR004699; PTS_IID_sorb.
DR   PANTHER; PTHR40399; PTHR40399; 1.
DR   Pfam; PF03608; EII-GUT; 1.
DR   PIRSF; PIRSF038321; PTS_glc_srb_IIC; 1.
DR   TIGRFAMs; TIGR00821; EII-GUT; 1.
DR   PROSITE; PS51107; PTS_EIIC_TYPE_5; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Membrane; Phosphotransferase system; Sugar transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..182
FT                   /note="PTS system glucitol/sorbitol-specific EIIC
FT                   component"
FT                   /id="PRO_0000186567"
FT   TRANSMEM        28..48
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00430"
FT   TRANSMEM        63..83
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00430"
FT   TRANSMEM        139..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00430"
FT   DOMAIN          1..182
FT                   /note="PTS EIIC type-5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00430"
SQ   SEQUENCE   182 AA;  20185 MW;  58EBE4D822677154 CRC64;
     MDAIVYFAKG FMYLFEVGGN TFVSWVTGII PKVLLLLVFM NSIIAFIGQD KVDRFAKFAS
     RNVILAYGVL PFLSAFMLGN PMALSMGKFL PERMKPSYYA SASYHCHTNS GIFPHINVGE
     IFIYLGIANG ITTLGLDPTA LGLRYLLVGL VMNFFAGWVT DFTTKIVMRQ QGIELSNQLK
     AN
 
 
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