PTHD1_DANRE
ID PTHD1_DANRE Reviewed; 897 AA.
AC Q5RIV7;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Patched domain-containing protein 1;
GN Name=ptchd1; ORFNames=si:ch211-105n9.1;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q96NR3};
CC Multi-pass membrane protein {ECO:0000250|UniProtKB:Q96NR3}.
CC -!- SIMILARITY: Belongs to the patched family. {ECO:0000305}.
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DR EMBL; BX088599; CAI11540.1; -; Genomic_DNA.
DR RefSeq; NP_001025356.1; NM_001030185.1.
DR AlphaFoldDB; Q5RIV7; -.
DR SMR; Q5RIV7; -.
DR STRING; 7955.ENSDARP00000115181; -.
DR PaxDb; Q5RIV7; -.
DR PRIDE; Q5RIV7; -.
DR Ensembl; ENSDART00000146055; ENSDARP00000115181; ENSDARG00000008249.
DR GeneID; 564097; -.
DR KEGG; dre:564097; -.
DR CTD; 442213; -.
DR ZFIN; ZDB-GENE-041001-178; ptchd4.
DR eggNOG; KOG1934; Eukaryota.
DR GeneTree; ENSGT00940000156827; -.
DR HOGENOM; CLU_002359_2_2_1; -.
DR InParanoid; Q5RIV7; -.
DR OMA; HTSHHET; -.
DR OrthoDB; 210960at2759; -.
DR PhylomeDB; Q5RIV7; -.
DR PRO; PR:Q5RIV7; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 20.
DR Bgee; ENSDARG00000008249; Expressed in retina and 1 other tissue.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR Pfam; PF02460; Patched; 1.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Cell membrane; Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..897
FT /note="Patched domain-containing protein 1"
FT /id="PRO_0000280042"
FT TRANSMEM 25..45
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..291
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 306..326
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 335..355
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 377..397
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 414..434
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 506..526
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 701..721
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 727..747
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 754..774
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 806..826
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 831..851
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 273..433
FT /note="SSD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00199"
FT REGION 856..881
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 132
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 167
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 179
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 332
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 572
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 603
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 803
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 897 AA; 102383 MW; B83FF1A795E420C1 CRC64;
MLRQVIHRGL KASFYWLGLF VSRHPVFFLT VPAVLTIIFG STVLSRFKPE TDLEILVAPT
HSLAKIERSL ANSLFPIDQS KHKLYSDLHT PGRYGRLILL ARSGGNILEL AEQVLQVHKK
VLDMRVNYKG FNYTFAHLCV LRHRDKRCLL DDIITIFEDI RLAVLSNSTF SKVPVSYPNT
TLKDGRVSFI GHQLGGVALP ANNRDQQVKF ARAIQITYYL RNLGPVVQDI IAEKWETEFC
KLVHQLATDS QELHIQSLTS FSLWRDFHKT GVLAKSEVLV SLVLVLLAAT ISSSMRDCLR
GKPFLGLLGV LTICIANVTA AGIFFISDGK FNSTLLGIPF FAMGHGTKGV FELLAGWRRT
RESLPFKERV ADAFADVMVC YTMTSSLYII TFGMGASPFT NIESVKVFCQ SMCVAVLVNY
FYVFSFYGSC LVFAGQLEQN RYHSVFCCKI PSVEYLDRQP TWFKTMMSDG HDLSTHHDSV
PYQNHFIQHF LREHYTEWIT NTYVKPFVVI LYLIYASFSF MGCLQISDGS NIINLLASNS
PSVSFALTQQ KYFSNYSPVI GFYIYEPIEY WNSTVQEHLK TLGQGFNKIS WIDNYFHFLR
VVNISASTKS DFISILKTSF LRSPEYQHFV DDIIFSKNGA EYDIIASKMY LVARTTEKTR
EEVVELLERL RPLSLINSIK FIVFNPTFVF MDRYSSSIIS PILTSGFSVL TILILTFFLV
INPLGNFWLI LTVTSVELGV LGLMTLWNVD MDSISILCLI YTLNFAMDHC APHLYTFVLA
TEHTRTQCIK ISLEEHGAAI LQNTSCFVIG IMPLLFVPSN LTYTLFKCSL LTAGCTVLHC
FVILPVFLTF FPPSKKRHKK KKRAKRKERE RERERERERE EIECIEVREN PDHVTNV
