ID   ATP25_AJECG             Reviewed;         731 AA.
AC   C0NWC4;
DT   08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 1.
DT   25-MAY-2022, entry version 29.
DE   RecName: Full=ATPase synthesis protein 25, mitochondrial;
DE   Flags: Precursor;
GN   Name=ATP25; ORFNames=HCBG_07454;
OS   Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432)
OS   (Darling's disease fungus) (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX   NCBI_TaxID=447093;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=G186AR / H82 / ATCC MYA-2454 / RMSCC 2432;
RA   Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Sil A., Goldman B.,
RA   Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.,
RA   Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA   Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C., Jen D., Larson L.,
RA   Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T.,
RA   Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C.,
RA   Klein B., McEwen J.G., Puccia R., Goldman G.H., Felipe M.S., Nino-Vega G.,
RA   San-Blas G., Taylor J., Mendoza L., Galagan J.E., Nusbaum C., Birren B.W.;
RT   "The genome sequence of Ajellomyces capsulatus strain G186AR.";
RL   Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable mitochondrial mRNA stabilization factor.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}; Matrix side {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ATP25 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; GG663374; EEH04229.1; -; Genomic_DNA.
DR   AlphaFoldDB; C0NWC4; -.
DR   SMR; C0NWC4; -.
DR   STRING; 447093.C0NWC4; -.
DR   PRIDE; C0NWC4; -.
DR   EnsemblFungi; EEH04229; EEH04229; HCBG_07454.
DR   VEuPathDB; FungiDB:HCBG_07454; -.
DR   HOGENOM; CLU_016140_0_0_1; -.
DR   InParanoid; C0NWC4; -.
DR   OrthoDB; 904950at2759; -.
DR   Proteomes; UP000001631; Unassembled WGS sequence.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0140053; P:mitochondrial gene expression; IEA:InterPro.
DR   Gene3D; 3.30.460.10; -; 1.
DR   InterPro; IPR040152; Atp25.
DR   InterPro; IPR043519; NT_sf.
DR   PANTHER; PTHR28087; PTHR28087; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transit peptide.
FT   TRANSIT         1..52
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           53..731
FT                   /note="ATPase synthesis protein 25, mitochondrial"
FT                   /id="PRO_0000404454"
FT   REGION          61..93
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          356..396
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        76..93
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        356..395
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   731 AA;  81927 MW;  3A246E0054CA4FAD CRC64;
     MSRVLLRGIQ CHACRSNVIR SFISLSDVAI TPLAGGSRST AQARPPPLSR NFSSQHAKLF
     SNQPSDNAEL SVDPIPEIHN GEEPEGQPEE SQEHIPWYLK EEQVEETIPH PLRRQQPLPP
     LPENPPPILE NLLEHISVDI GLDNLSLLDL RRLDPPPALG ANLIMIFGTA RGVKHLNVSA
     DRLCRWLRTT YKLRPDADGL LGRNELKIKL RRKARRAKLA KSAKSTLTQP DDGITTGWIC
     VDVGTVEGGQ FRKPEEELRK VGFVGFGTVV EGTRIVVQMM TEEKREEIDL EGLWRQKLER
     NSLENEGLPQ PQAAAPQEAG DIHEQLTIPP TNINHQISHA TQISPNYEQR RGISTGSRYQ
     DATSDTWGTS RISPNGETTH LEPSAPSSPT SLSHRFKNIP PHEAIYDLGQ GTHDRCSTAF
     LQQFYQEVAR APSELASSRR IELMCIAIEL HHPGYRKPDL FQAIQEHILS NYALTRAQFL
     QILDAFLSFK PDLTSNPPRL LLPNADMELA LQIIDHAGLR GLNLLDSTIL VKLFVGVSFR
     AQVYPVEQKD LPNSPVIGNR IPVPLNTCDA VKRVQSRLTR VKTAAKISFT AEQYMKILRV
     LFDQGSYSGF WNTWEDMALA GVARDKALYV FLFQLHAESD GWQCFTTQLL NCIPMMEREN
     PPVHLDGELA EVTQKCITIA YPEIIDRVER NEQNPLVRMW HRCRVAIENA AAAGGRGQDS
     TAPYVCNHSD I