PTHD3_RAT
ID PTHD3_RAT Reviewed; 905 AA.
AC M0R3Q7;
DT 25-MAY-2022, integrated into UniProtKB/Swiss-Prot.
DT 03-APR-2013, sequence version 1.
DT 03-AUG-2022, entry version 48.
DE RecName: Full=Patched domain-containing protein 3 {ECO:0000312|RGD:1590039};
GN Name=Ptchd3 {ECO:0000312|RGD:1590039};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000312|Proteomes:UP000002494};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0000305}
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=17904097; DOI=10.1016/j.bbrc.2007.09.047;
RA Fan J., Akabane H., Zheng X., Zhou X., Zhang L., Liu Q., Zhang Y.-L.,
RA Yang J., Zhu G.-Z.;
RT "Male germ cell-specific expression of a novel patched-domain containing
RT gene Ptchd3.";
RL Biochem. Biophys. Res. Commun. 363:757-761(2007).
CC -!- FUNCTION: May play a role in sperm development or sperm function.
CC However, does not appear to have an essential role in spermatogenesis
CC or male fertility. {ECO:0000250|UniProtKB:Q0EEE2}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum membrane
CC {ECO:0000269|PubMed:17904097}; Multi-pass membrane protein
CC {ECO:0000255}. Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:Q3KNS1}; Multi-pass membrane protein
CC {ECO:0000255}. Note=Localizes to the midpiece of the sperm tail.
CC {ECO:0000269|PubMed:17904097}.
CC -!- TISSUE SPECIFICITY: Expressed in germ cells of the testis (at protein
CC level). {ECO:0000269|PubMed:17904097}.
CC -!- SIMILARITY: Belongs to the patched family. {ECO:0000305}.
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DR EMBL; AABR07030946; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_001081846.1; XM_001081846.4.
DR RefSeq; XP_003751038.1; XM_003750990.4.
DR AlphaFoldDB; M0R3Q7; -.
DR SMR; M0R3Q7; -.
DR STRING; 10116.ENSRNOP00000063978; -.
DR PaxDb; M0R3Q7; -.
DR Ensembl; ENSRNOT00000074372; ENSRNOP00000063978; ENSRNOG00000046946.
DR GeneID; 688333; -.
DR KEGG; rno:688333; -.
DR CTD; 374308; -.
DR RGD; 1590039; Ptchd3.
DR eggNOG; KOG1935; Eukaryota.
DR GeneTree; ENSGT00940000158727; -.
DR HOGENOM; CLU_002359_2_1_1; -.
DR InParanoid; M0R3Q7; -.
DR OMA; KKIMLFQ; -.
DR OrthoDB; 210960at2759; -.
DR Proteomes; UP000002494; Chromosome 10.
DR Bgee; ENSRNOG00000046946; Expressed in testis and 2 other tissues.
DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0097225; C:sperm midpiece; IDA:UniProtKB.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR Pfam; PF02460; Patched; 1.
DR PROSITE; PS50156; SSD; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Cell projection; Cilium; Endoplasmic reticulum; Flagellum;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..905
FT /note="Patched domain-containing protein 3"
FT /id="PRO_0000455683"
FT TRANSMEM 94..114
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 337..357
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 369..389
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 391..411
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 441..461
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 475..495
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 558..578
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 759..779
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 781..801
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 813..833
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 849..869
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 882..902
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 338..495
FT /note="SSD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00199"
FT REGION 1..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..36
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 146
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 199
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 229
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 233
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 647
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 661
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 692
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 905 AA; 101843 MW; F5F4D6F76DDEA56C CRC64;
MISSKVAPGE EEEQQEAPAE VAPAEEELRE TEGQLEAVPP DEASPSWATG PPLERLPPVG
QEAPPPRRCH TDCLEAPLSS CFLRLGALVG ANPWLFLLGP VLLTASLGTG LIFLPKEKEN
LEEQYTPIGS PAKAERRFVQ SHFSTNDSYR FSASRTSSET NFASILVVSH RDSLLEPEAF
AEVSRLDRAV QALKVVQENG TQILYPEVCA KYSVGCVPPN PLLFSWQQNS SLNLSELTFP
IHSVADHLIH LAGFFGGNVL GYATTGNRQR LVESRAMRLL YYLKTEDPED RERSQAWLTH
FLDHFNDMKS DLALEDIEVV YFTSLSRQLE FEATSKTVIP LFHLAYILII LFAVVSCSRL
DCIRNKMWVA VFGVFSVAMS VVSGFGLMLH IGVPFVIIVA NSPFLILGVG VDDMFIMISA
WQKTSLTESV SERLSNSYSK VAVSITITTI TNVLAFYTGI TSSFRSVQYF CIYTGTTLLF
CYFYSITCFG AIMALDGKRE VVWSRWLEKP DQKYSSFKKF CCVPFGSFPD EHGDDNHPMN
LFFRDYFGPF LTTSKAKFIV VLIYIFYIIS SIYGCFQVQE GLDLRNLASD DSYITPYFNV
EEDYFSDYGP RVMVIVTETV NYWDKDVRQK LDKCMTQFEQ NEYVDKNLTE FWLEAYMQYM
NNTGNNPNDK NTFMNNIAGF LNFFPVFTYD INVSSSNEIT SSRGFIQTID VSSSSNKKRM
LLKLRGIAEN CEVPLMVYNQ AFIYFDQYAA IIENTVRNVM IASTAMFIVS LLLIPHPVCS
LWVTFAIASV IVGVTGFMAF WNVNLDSISM INLVICIGFS FDFSAHISYA FVSSNEPSVN
KKSIEALYLL GYPVLQSAIS TIIGVCVLAA AKAYIFRTFF KIMFLVMFFG AAHGLIFIPV
FLTFF
