PTHD4_MOUSE
ID PTHD4_MOUSE Reviewed; 904 AA.
AC B9EKX1;
DT 24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-NOV-2009, sequence version 2.
DT 03-AUG-2022, entry version 62.
DE RecName: Full=Patched domain-containing protein 4;
GN Name=Ptchd4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Could act as a repressor of canonical hedgehog signaling by
CC antagonizing the effects of SMO, as suggested by down-regulation of
CC hedgehog target genes, including GLI1, PTCH1, and PTCH2 in PTCHD4-
CC expressing cells. {ECO:0000250|UniProtKB:Q6ZW05}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the patched family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI51167.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; BC151166; AAI51167.1; ALT_INIT; mRNA.
DR CCDS; CCDS89098.1; -.
DR RefSeq; XP_006524814.1; XM_006524751.1.
DR RefSeq; XP_006524815.1; XM_006524752.2.
DR AlphaFoldDB; B9EKX1; -.
DR SMR; B9EKX1; -.
DR BioGRID; 553632; 2.
DR STRING; 10090.ENSMUSP00000047640; -.
DR GlyGen; B9EKX1; 3 sites.
DR iPTMnet; B9EKX1; -.
DR PhosphoSitePlus; B9EKX1; -.
DR PaxDb; B9EKX1; -.
DR PRIDE; B9EKX1; -.
DR ProteomicsDB; 302009; -.
DR Antibodypedia; 48920; 99 antibodies from 19 providers.
DR Ensembl; ENSMUST00000232968; ENSMUSP00000156770; ENSMUSG00000042256.
DR GeneID; 627626; -.
DR CTD; 442213; -.
DR MGI; MGI:1920485; Ptchd4.
DR VEuPathDB; HostDB:ENSMUSG00000042256; -.
DR eggNOG; KOG1934; Eukaryota.
DR GeneTree; ENSGT00940000156827; -.
DR InParanoid; B9EKX1; -.
DR OrthoDB; 210960at2759; -.
DR PhylomeDB; B9EKX1; -.
DR BioGRID-ORCS; 627626; 6 hits in 71 CRISPR screens.
DR ChiTaRS; Ptchd4; mouse.
DR PRO; PR:B9EKX1; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; B9EKX1; protein.
DR Bgee; ENSMUSG00000042256; Expressed in lumbar subsegment of spinal cord and 91 other tissues.
DR ExpressionAtlas; B9EKX1; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR Pfam; PF02460; Patched; 1.
DR PROSITE; PS50156; SSD; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..904
FT /note="Patched domain-containing protein 4"
FT /id="PRO_0000389444"
FT TRANSMEM 41..61
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 295..312
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 323..343
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 351..371
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 394..414
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 431..451
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 523..543
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 718..738
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 744..764
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 771..791
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 823..843
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 845..865
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 291..450
FT /note="SSD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00199"
FT CARBOHYD 149
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 625
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 820
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 904 AA; 103115 MW; 80C5778BC3EEA40F CRC64;
MCFLRRPGAP ASWIWWRMLR QVLRRGLQSF CHRLGLCVSR HPVFFLTVPA VLTITFGLSA
LNRFQTEGDL ERLVAPSHSL AKIERSLASS LFPLDQSKSQ LYSDLHTPGR YGRVILLSSP
GDNILLQAEG ILQTHRAVME MKVNHKGYNY TFSHLCVLRN QDKKCVLDDI ISVLEDLRQA
AVSNKTTARV QVRYPNTKLK DGRNSFIGHQ LGGVVEVPNS KDQRVKSARA IQITYYLQTY
GSATQDLIGE KWENEFCKLM RKLQEEHQDL QLYSLASFSL WRDFHKTSIL TRSKVLVSLV
LILTTATLSS SMKDCLRSKP FLGLLGVLTV CISIATAAGI FFITDGKYNS TLLGIPFFAM
GHGTKGVFEL LSGWRRTKEN LPFKDRVADA YSDVMVTYTM TSSLYFITFG MGASPFTNIE
AVKIFCQNMC VSILLNYFYI FSFFGSCLVF AGQLEQNRYH SIFCCKIPSA EYLDRKPVWF
QTVMSDGHQQ TSHHETNPYQ HHFIQHFLRE HYNEWITNIY VKPFVVILYL IYASFSFMGC
LQISDGASII NLLASDSPSV SYAMVQQKYF SNYSPVIGFY VYEPLEYWNS SVQEDLQRLC
SGFTAVSWVE QYYQFLKTSN ISANNKTDFI SVLQSSFLKK PEFQHFRNDI IFSRAGDENN
IIASRLYLVA RTSRDKQKEV IEVLDKLRPL SLSKSIRFIV FNPSFVFTDH YSLSVTVPVL
IAGFGVLLVL ILTFFLVIHP LGNFWLILSV TSIELGVLGL MTLWNVDMDC ISILCLIYTL
NFAIDHCAPL LYTFVLATEH TRTQCIKSSL QEHGTAILQN ITSFLIGLLP LLFVPSNLTF
TLFKCLLLTG GCTLLHCFVI LPVFLTFFPP SKKHHKKKKR AKRKEREEIE CIEIQENPDH
VTTV
