ID   PTHP_SALTY              Reviewed;          85 AA.
AC   P0AA07; P05525; P07006;
DT   01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1988, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Phosphocarrier protein HPr;
DE   AltName: Full=Histidine-containing protein;
GN   Name=ptsH; Synonyms=hpr; OrderedLocusNames=STM2431;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=6754732; DOI=10.1016/s0021-9258(19)45407-0;
RA   Weigel N., Powers D.A., Roseman S.;
RT   "Sugar transport by the bacterial phosphotransferase system. Primary
RT   structure and active site of a general phosphocarrier protein (HPr) from
RT   Salmonella typhimurium.";
RL   J. Biol. Chem. 257:14499-14509(1982).
RN   [2]
RP   SEQUENCE REVISION.
RX   PubMed=6392295; DOI=10.1016/s0021-9258(17)42536-1;
RA   Powers D.A., Roseman S.;
RT   "The primary structure of Salmonella typhimurium HPr, a phosphocarrier
RT   protein of the phosphoenolpyruvate:glycose phosphotransferase system. A
RT   correction.";
RL   J. Biol. Chem. 259:15212-15214(1984).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=LT2;
RX   PubMed=3290198; DOI=10.1128/jb.170.7.3150-3157.1988;
RA   Byrne C.R., Monroe R.S., Ward K.A., Kredich N.M.;
RT   "DNA sequences of the cysK regions of Salmonella typhimurium and
RT   Escherichia coli and linkage of the cysK regions to ptsH.";
RL   J. Bacteriol. 170:3150-3157(1988).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=LT2;
RX   PubMed=2497295; DOI=10.1111/j.1365-2958.1989.tb00110.x;
RA   Schnierow B.J., Yamada M., Saier M.H. Jr.;
RT   "Partial nucleotide sequence of the pts operon in Salmonella typhimurium:
RT   comparative analyses in five bacterial genera.";
RL   Mol. Microbiol. 3:113-118(1989).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: General (non sugar-specific) component of the
CC       phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar
CC       PTS). This major carbohydrate active-transport system catalyzes the
CC       phosphorylation of incoming sugar substrates concomitantly with their
CC       translocation across the cell membrane. The phosphoryl group from
CC       phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier
CC       protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA
CC       domain. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the HPr family. {ECO:0000305}.
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DR   EMBL; M21450; AAA27052.1; -; Genomic_DNA.
DR   EMBL; X14737; CAA32865.1; -; Genomic_DNA.
DR   EMBL; AE006468; AAL21325.1; -; Genomic_DNA.
DR   PIR; C28181; WQEBPH.
DR   RefSeq; NP_461366.1; NC_003197.2.
DR   RefSeq; WP_000487600.1; NC_003197.2.
DR   AlphaFoldDB; P0AA07; -.
DR   BMRB; P0AA07; -.
DR   SMR; P0AA07; -.
DR   STRING; 99287.STM2431; -.
DR   PaxDb; P0AA07; -.
DR   ABCD; P0AA07; 1 sequenced antibody.
DR   EnsemblBacteria; AAL21325; AAL21325; STM2431.
DR   GeneID; 1253953; -.
DR   GeneID; 64724046; -.
DR   GeneID; 67461150; -.
DR   KEGG; stm:STM2431; -.
DR   PATRIC; fig|99287.12.peg.2569; -.
DR   HOGENOM; CLU_136230_2_3_6; -.
DR   OMA; APHGIHT; -.
DR   PhylomeDB; P0AA07; -.
DR   BioCyc; SENT99287:STM2431-MON; -.
DR   PRO; PR:P0AA07; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009401; P:phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:UniProtKB-KW.
DR   CDD; cd00367; PTS-HPr_like; 1.
DR   Gene3D; 3.30.1340.10; -; 1.
DR   InterPro; IPR000032; HPr-like.
DR   InterPro; IPR035895; HPr-like_sf.
DR   InterPro; IPR001020; PTS_HPr_His_P_site.
DR   InterPro; IPR002114; PTS_HPr_Ser_P_site.
DR   Pfam; PF00381; PTS-HPr; 1.
DR   PRINTS; PR00107; PHOSPHOCPHPR.
DR   SUPFAM; SSF55594; SSF55594; 1.
DR   TIGRFAMs; TIGR01003; PTS_HPr_family; 1.
DR   PROSITE; PS51350; PTS_HPR_DOM; 1.
DR   PROSITE; PS00369; PTS_HPR_HIS; 1.
DR   PROSITE; PS00589; PTS_HPR_SER; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Direct protein sequencing; Phosphotransferase system;
KW   Reference proteome; Sugar transport; Transport.
FT   CHAIN           1..85
FT                   /note="Phosphocarrier protein HPr"
FT                   /id="PRO_0000107870"
FT   DOMAIN          1..85
FT                   /note="HPr"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00681"
FT   ACT_SITE        15
FT                   /note="Pros-phosphohistidine intermediate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00681"
SQ   SEQUENCE   85 AA;  9119 MW;  E5C8879C0A95AD41 CRC64;
     MFQQEVTITA PNGLHTRPAA QFVKEAKGFT SEITVTSNGK SASAKSLFKL QTLGLTQGTV
     VTISAEGEDE QKAVEHLVKL MAELE