PTHY_CANLF
ID PTHY_CANLF Reviewed; 115 AA.
AC P52212;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Parathyroid hormone;
DE Short=PTH;
DE AltName: Full=Parathyrin;
DE Flags: Precursor;
GN Name=PTH;
OS Canis lupus familiaris (Dog) (Canis familiaris).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX NCBI_TaxID=9615;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Parathyroid;
RX PubMed=7642102; DOI=10.1016/0378-1119(94)00912-c;
RA Rosol T.J., Steinmeyer C.L., McCauley L.K., Groene A., DeWille J.W.,
RA Capen C.C.;
RT "Sequences of the cDNAs encoding canine parathyroid hormone-related protein
RT and parathyroid hormone.";
RL Gene 160:241-243(1995).
CC -!- FUNCTION: PTH elevates calcium level by dissolving the salts in bone
CC and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-
CC glucose (2DG) transport and glycogen synthesis in osteoblastic cells
CC (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with PTH1R (via N-terminal extracellular domain).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the parathyroid hormone family. {ECO:0000305}.
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DR EMBL; U15662; AAA82584.1; -; mRNA.
DR PIR; JC4202; JC4202.
DR RefSeq; NP_001003302.1; NM_001003302.1.
DR RefSeq; XP_005633342.1; XM_005633285.2.
DR RefSeq; XP_013977895.1; XM_014122420.1.
DR AlphaFoldDB; P52212; -.
DR STRING; 9615.ENSCAFP00000053878; -.
DR PaxDb; P52212; -.
DR Ensembl; ENSCAFT00030047835; ENSCAFP00030041845; ENSCAFG00030025903.
DR Ensembl; ENSCAFT00040036084; ENSCAFP00040031486; ENSCAFG00040019502.
DR Ensembl; ENSCAFT00845036775; ENSCAFP00845028792; ENSCAFG00845020842.
DR GeneID; 403986; -.
DR KEGG; cfa:403986; -.
DR CTD; 5741; -.
DR VEuPathDB; HostDB:ENSCAFG00845020842; -.
DR eggNOG; ENOG502SB2W; Eukaryota.
DR GeneTree; ENSGT00390000018603; -.
DR HOGENOM; CLU_164143_0_0_1; -.
DR InParanoid; P52212; -.
DR OMA; HNLGEHR; -.
DR OrthoDB; 1482128at2759; -.
DR TreeFam; TF336197; -.
DR Reactome; R-CFA-373080; Class B/2 (Secretin family receptors).
DR Reactome; R-CFA-418555; G alpha (s) signalling events.
DR Proteomes; UP000002254; Chromosome 21.
DR Bgee; ENSCAFG00000008177; Expressed in thyroid gland and 42 other tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR GO; GO:0031856; F:parathyroid hormone receptor binding; IBA:GO_Central.
DR GO; GO:0051428; F:peptide hormone receptor binding; ISS:UniProtKB.
DR GO; GO:0047485; F:protein N-terminus binding; IEA:Ensembl.
DR GO; GO:0031857; F:type 1 parathyroid hormone receptor binding; IEA:Ensembl.
DR GO; GO:0007202; P:activation of phospholipase C activity; IEA:Ensembl.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0030282; P:bone mineralization; IEA:Ensembl.
DR GO; GO:0007267; P:cell-cell signaling; IBA:GO_Central.
DR GO; GO:0006874; P:cellular calcium ion homeostasis; IEA:Ensembl.
DR GO; GO:0034645; P:cellular macromolecule biosynthetic process; IEA:Ensembl.
DR GO; GO:0048873; P:homeostasis of number of cells within a tissue; IEA:Ensembl.
DR GO; GO:0010960; P:magnesium ion homeostasis; IEA:Ensembl.
DR GO; GO:0071866; P:negative regulation of apoptotic process in bone marrow cell; IEA:Ensembl.
DR GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
DR GO; GO:0055062; P:phosphate ion homeostasis; IEA:Ensembl.
DR GO; GO:0030501; P:positive regulation of bone mineralization; IEA:Ensembl.
DR GO; GO:0071864; P:positive regulation of cell proliferation in bone marrow; IEA:Ensembl.
DR GO; GO:0046326; P:positive regulation of glucose import; ISS:UniProtKB.
DR GO; GO:0045725; P:positive regulation of glycogen biosynthetic process; ISS:UniProtKB.
DR GO; GO:0060732; P:positive regulation of inositol phosphate biosynthetic process; IEA:Ensembl.
DR GO; GO:0090290; P:positive regulation of osteoclast proliferation; IEA:Ensembl.
DR GO; GO:0009967; P:positive regulation of signal transduction; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IEA:Ensembl.
DR InterPro; IPR003625; PTH.
DR InterPro; IPR001415; PTH/PTH-rel.
DR PANTHER; PTHR10541; PTHR10541; 1.
DR Pfam; PF01279; Parathyroid; 1.
DR PIRSF; PIRSF001832; PTH; 1.
DR SMART; SM00087; PTH; 1.
DR PROSITE; PS00335; PARATHYROID; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues; Hormone; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000250"
FT PROPEP 26..31
FT /evidence="ECO:0000250"
FT /id="PRO_0000023245"
FT CHAIN 32..115
FT /note="Parathyroid hormone"
FT /id="PRO_0000023246"
FT REGION 51..69
FT /note="Important for receptor binding"
FT /evidence="ECO:0000250"
SQ SEQUENCE 115 AA; 12957 MW; FC38F77F1C8CFE56 CRC64;
MMSAKDMVKV MIVMFAICFL AKSDGKPVKK RSVSEIQFMH NLGKHLSSME RVEWLRKKLQ
DVHNFVALGA PIAHRDGSSQ RPLKKEDNVL VESYQKSLGE ADKADVDVLT KAKSQ
