ID   PTHY_FELCA              Reviewed;         115 AA.
AC   Q9GL67;
DT   10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Parathyroid hormone;
DE            Short=PTH;
DE   AltName: Full=Parathyrin;
DE   Flags: Precursor;
GN   Name=PTH;
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX   NCBI_TaxID=9685;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Toribio R.E., Kohn C.W., Leone G.W., Capen C.C., Rosol T.J.;
RT   "Molecular cloning of feline preproparathyroid hormone.";
RL   Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: PTH elevates calcium level by dissolving the salts in bone
CC       and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-
CC       glucose (2DG) transport and glycogen synthesis in osteoblastic cells
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with PTH1R (via N-terminal extracellular domain).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the parathyroid hormone family. {ECO:0000305}.
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DR   EMBL; AF309967; AAG30545.1; -; mRNA.
DR   RefSeq; NP_001009210.1; NM_001009210.1.
DR   AlphaFoldDB; Q9GL67; -.
DR   STRING; 9685.ENSFCAP00000005755; -.
DR   PRIDE; Q9GL67; -.
DR   Ensembl; ENSFCAT00000058712; ENSFCAP00000042163; ENSFCAG00000045547.
DR   GeneID; 493684; -.
DR   KEGG; fca:493684; -.
DR   CTD; 5741; -.
DR   eggNOG; ENOG502SB2W; Eukaryota.
DR   GeneTree; ENSGT00390000018603; -.
DR   HOGENOM; CLU_164143_0_0_1; -.
DR   InParanoid; Q9GL67; -.
DR   OMA; HNLGEHR; -.
DR   OrthoDB; 1482128at2759; -.
DR   TreeFam; TF336197; -.
DR   Proteomes; UP000011712; Chromosome D1.
DR   Bgee; ENSFCAG00000045547; Expressed in embryonic head and 3 other tissues.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR   GO; GO:0031856; F:parathyroid hormone receptor binding; IBA:GO_Central.
DR   GO; GO:0051428; F:peptide hormone receptor binding; ISS:UniProtKB.
DR   GO; GO:0047485; F:protein N-terminus binding; IEA:Ensembl.
DR   GO; GO:0031857; F:type 1 parathyroid hormone receptor binding; IEA:Ensembl.
DR   GO; GO:0007202; P:activation of phospholipase C activity; IEA:Ensembl.
DR   GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0030282; P:bone mineralization; IEA:Ensembl.
DR   GO; GO:0007267; P:cell-cell signaling; IBA:GO_Central.
DR   GO; GO:0006874; P:cellular calcium ion homeostasis; IEA:Ensembl.
DR   GO; GO:0034645; P:cellular macromolecule biosynthetic process; IEA:Ensembl.
DR   GO; GO:0048873; P:homeostasis of number of cells within a tissue; IEA:Ensembl.
DR   GO; GO:0010960; P:magnesium ion homeostasis; IEA:Ensembl.
DR   GO; GO:0071866; P:negative regulation of apoptotic process in bone marrow cell; IEA:Ensembl.
DR   GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0055062; P:phosphate ion homeostasis; IEA:Ensembl.
DR   GO; GO:0030501; P:positive regulation of bone mineralization; IEA:Ensembl.
DR   GO; GO:0071864; P:positive regulation of cell proliferation in bone marrow; IEA:Ensembl.
DR   GO; GO:0046326; P:positive regulation of glucose import; ISS:UniProtKB.
DR   GO; GO:0045725; P:positive regulation of glycogen biosynthetic process; ISS:UniProtKB.
DR   GO; GO:0060732; P:positive regulation of inositol phosphate biosynthetic process; IEA:Ensembl.
DR   GO; GO:0090290; P:positive regulation of osteoclast proliferation; IEA:Ensembl.
DR   GO; GO:0009967; P:positive regulation of signal transduction; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0006366; P:transcription by RNA polymerase II; IEA:Ensembl.
DR   InterPro; IPR003625; PTH.
DR   InterPro; IPR001415; PTH/PTH-rel.
DR   PANTHER; PTHR10541; PTHR10541; 1.
DR   Pfam; PF01279; Parathyroid; 1.
DR   PIRSF; PIRSF001832; PTH; 1.
DR   SMART; SM00087; PTH; 1.
DR   PROSITE; PS00335; PARATHYROID; 1.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues; Hormone; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000250"
FT   PROPEP          26..31
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000023247"
FT   CHAIN           32..115
FT                   /note="Parathyroid hormone"
FT                   /id="PRO_0000023248"
FT   REGION          51..69
FT                   /note="Important for receptor binding"
FT                   /evidence="ECO:0000250"
FT   REGION          72..106
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        77..106
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   115 AA;  12921 MW;  80CD557CC6A1A47E CRC64;
     MMSAKDMVKV MVVMFAICFL AKSDGKPVKK RSVSEIQFMH NLGKHLSSVE RVEWLRRKLQ
     DVHNFVALGA PIAHRDGGSQ RPRKKEDNVP AENHQKSLGE ADKADVDVLI KAKSQ