ID   PTHY_MACFA              Reviewed;         115 AA.
AC   Q9XT35;
DT   21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Parathyroid hormone;
DE            Short=PTH;
DE   AltName: Full=Parathyrin;
DE   Flags: Precursor;
GN   Name=PTH;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Malaivijitnond S., Takenaka O.;
RT   "Nucleotide sequences of parathyroid gene in five species of macaque of
RT   Thailand.";
RL   J. Sci. Res. Chulalongkorn Univ. 23:135-142(1998).
CC   -!- FUNCTION: PTH elevates calcium level by dissolving the salts in bone
CC       and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-
CC       glucose (2DG) transport and glycogen synthesis in osteoblastic cells
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with PTH1R (via N-terminal extracellular domain).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the parathyroid hormone family. {ECO:0000305}.
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DR   EMBL; AF130257; AAD42777.1; -; Genomic_DNA.
DR   RefSeq; XP_005578619.1; XM_005578562.2.
DR   AlphaFoldDB; Q9XT35; -.
DR   BMRB; Q9XT35; -.
DR   STRING; 9541.XP_005578619.1; -.
DR   GeneID; 102145320; -.
DR   KEGG; mcf:102145320; -.
DR   CTD; 5741; -.
DR   VEuPathDB; HostDB:ENSMFAG00000032854; -.
DR   eggNOG; ENOG502SB2W; Eukaryota.
DR   OMA; HNLGEHR; -.
DR   OrthoDB; 1482128at2759; -.
DR   Proteomes; UP000233100; Chromosome 14.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0051428; F:peptide hormone receptor binding; ISS:UniProtKB.
DR   GO; GO:0006874; P:cellular calcium ion homeostasis; IEA:InterPro.
DR   GO; GO:0046326; P:positive regulation of glucose import; ISS:UniProtKB.
DR   GO; GO:0045725; P:positive regulation of glycogen biosynthetic process; ISS:UniProtKB.
DR   InterPro; IPR003625; PTH.
DR   InterPro; IPR001415; PTH/PTH-rel.
DR   PANTHER; PTHR10541; PTHR10541; 1.
DR   Pfam; PF01279; Parathyroid; 1.
DR   PIRSF; PIRSF001832; PTH; 1.
DR   SMART; SM00087; PTH; 1.
DR   PROSITE; PS00335; PARATHYROID; 1.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues; Hormone; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000250"
FT   PROPEP          26..31
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000023251"
FT   CHAIN           32..115
FT                   /note="Parathyroid hormone"
FT                   /id="PRO_0000023252"
FT   REGION          51..69
FT                   /note="Important for receptor binding"
FT                   /evidence="ECO:0000250"
FT   REGION          72..96
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        78..96
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   115 AA;  12890 MW;  8C2500EF24BE5597 CRC64;
     MIPAKDMAKV MIVMLAICFL TKSDGKSVKK RSVSEIQLMH NLGKHLNSME RVEWLRKKLQ
     DVHNFIALGA PLAPRDAGSQ RPRKKEDNIL VESHEKSLGE ADKADVDVLT KAKSQ