PTHY_PIG
ID PTHY_PIG Reviewed; 115 AA.
AC P01269;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1988, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Parathyroid hormone;
DE Short=PTH;
DE AltName: Full=Parathyrin;
DE Flags: Precursor;
GN Name=PTH;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=3628009; DOI=10.1093/nar/15.16.6740;
RA Schmelzer H.-J., Gross G., Widera G., Mayer H.;
RT "Nucleotide sequence of a full-length cDNA clone encoding preproparathyroid
RT hormone from pig and rat.";
RL Nucleic Acids Res. 15:6740-6740(1987).
RN [2]
RP PROTEIN SEQUENCE OF 26-115.
RX PubMed=1164500; DOI=10.1021/bi00687a018;
RA Chu L.L.H., Huang W.-Y., Littledike E.T., Hamilton J.W., Cohn D.V.;
RT "Porcine proparathyroid hormone. Identification, biosynthesis, and partial
RT amino acid sequence.";
RL Biochemistry 14:3631-3635(1975).
RN [3]
RP PROTEIN SEQUENCE OF 32-115.
RX PubMed=4840833; DOI=10.1021/bi00706a033;
RA Sauer R.T., Niall H.D., Hogan M.L., Keutmann H.T., O'Riordan J.L.H.,
RA Potts J.T. Jr.;
RT "The amino acid sequence of porcine parathyroid hormone.";
RL Biochemistry 13:1994-1999(1974).
CC -!- FUNCTION: PTH elevates calcium level by dissolving the salts in bone
CC and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-
CC glucose (2DG) transport and glycogen synthesis in osteoblastic cells
CC (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with PTH1R (via N-terminal extracellular domain).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the parathyroid hormone family. {ECO:0000305}.
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DR EMBL; X05722; CAA29193.1; -; mRNA.
DR PIR; B26806; PTPG.
DR RefSeq; NP_999566.1; NM_214401.1.
DR AlphaFoldDB; P01269; -.
DR STRING; 9823.ENSSSCP00000014236; -.
DR PaxDb; P01269; -.
DR Ensembl; ENSSSCT00000014631; ENSSSCP00000014236; ENSSSCG00000013394.
DR Ensembl; ENSSSCT00005055967; ENSSSCP00005034470; ENSSSCG00005035061.
DR Ensembl; ENSSSCT00015054512; ENSSSCP00015021855; ENSSSCG00015040780.
DR Ensembl; ENSSSCT00025075705; ENSSSCP00025032816; ENSSSCG00025055306.
DR Ensembl; ENSSSCT00030031957; ENSSSCP00030014391; ENSSSCG00030023012.
DR Ensembl; ENSSSCT00035080020; ENSSSCP00035032944; ENSSSCG00035059707.
DR Ensembl; ENSSSCT00040091144; ENSSSCP00040040152; ENSSSCG00040066687.
DR Ensembl; ENSSSCT00045034739; ENSSSCP00045024095; ENSSSCG00045020365.
DR Ensembl; ENSSSCT00050053321; ENSSSCP00050022397; ENSSSCG00050039514.
DR Ensembl; ENSSSCT00055053171; ENSSSCP00055042429; ENSSSCG00055026883.
DR Ensembl; ENSSSCT00060025268; ENSSSCP00060010673; ENSSSCG00060018787.
DR Ensembl; ENSSSCT00070019355; ENSSSCP00070016104; ENSSSCG00070009958.
DR Ensembl; ENSSSCT00070019360; ENSSSCP00070016109; ENSSSCG00070009958.
DR GeneID; 399502; -.
DR KEGG; ssc:399502; -.
DR CTD; 5741; -.
DR VGNC; VGNC:91960; PTH.
DR eggNOG; ENOG502SB2W; Eukaryota.
DR GeneTree; ENSGT00390000018603; -.
DR HOGENOM; CLU_164143_0_0_1; -.
DR InParanoid; P01269; -.
DR OMA; HNLGEHR; -.
DR OrthoDB; 1482128at2759; -.
DR Proteomes; UP000008227; Chromosome 2.
DR Proteomes; UP000314985; Chromosome 2.
DR Bgee; ENSSSCG00000013394; Expressed in epididymis and 21 other tissues.
DR Genevisible; P01269; SS.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR GO; GO:0031856; F:parathyroid hormone receptor binding; IBA:GO_Central.
DR GO; GO:0051428; F:peptide hormone receptor binding; ISS:UniProtKB.
DR GO; GO:0047485; F:protein N-terminus binding; IEA:Ensembl.
DR GO; GO:0031857; F:type 1 parathyroid hormone receptor binding; IEA:Ensembl.
DR GO; GO:0007202; P:activation of phospholipase C activity; IEA:Ensembl.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0030282; P:bone mineralization; IEA:Ensembl.
DR GO; GO:0007267; P:cell-cell signaling; IBA:GO_Central.
DR GO; GO:0006874; P:cellular calcium ion homeostasis; IEA:Ensembl.
DR GO; GO:0034645; P:cellular macromolecule biosynthetic process; IEA:Ensembl.
DR GO; GO:0048873; P:homeostasis of number of cells within a tissue; IEA:Ensembl.
DR GO; GO:0010960; P:magnesium ion homeostasis; IEA:Ensembl.
DR GO; GO:0071866; P:negative regulation of apoptotic process in bone marrow cell; IEA:Ensembl.
DR GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
DR GO; GO:0055062; P:phosphate ion homeostasis; IEA:Ensembl.
DR GO; GO:0030501; P:positive regulation of bone mineralization; IEA:Ensembl.
DR GO; GO:0071864; P:positive regulation of cell proliferation in bone marrow; IEA:Ensembl.
DR GO; GO:0046326; P:positive regulation of glucose import; ISS:UniProtKB.
DR GO; GO:0045725; P:positive regulation of glycogen biosynthetic process; ISS:UniProtKB.
DR GO; GO:0060732; P:positive regulation of inositol phosphate biosynthetic process; IEA:Ensembl.
DR GO; GO:0090290; P:positive regulation of osteoclast proliferation; IEA:Ensembl.
DR GO; GO:0009967; P:positive regulation of signal transduction; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IEA:Ensembl.
DR InterPro; IPR003625; PTH.
DR InterPro; IPR001415; PTH/PTH-rel.
DR PANTHER; PTHR10541; PTHR10541; 1.
DR Pfam; PF01279; Parathyroid; 1.
DR PIRSF; PIRSF001832; PTH; 1.
DR SMART; SM00087; PTH; 1.
DR PROSITE; PS00335; PARATHYROID; 1.
PE 1: Evidence at protein level;
KW Cleavage on pair of basic residues; Direct protein sequencing; Hormone;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000269|PubMed:1164500"
FT PROPEP 26..31
FT /evidence="ECO:0000269|PubMed:4840833"
FT /id="PRO_0000023253"
FT CHAIN 32..115
FT /note="Parathyroid hormone"
FT /id="PRO_0000023254"
FT REGION 51..69
FT /note="Important for receptor binding"
FT /evidence="ECO:0000250"
FT REGION 75..98
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 77..98
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 115 AA; 12852 MW; 9FE8BCDE614BAC16 CRC64;
MMSAKDTVKV MVVMLAICFL ARSDGKPIKK RSVSEIQLMH NLGKHLSSLE RVEWLRKKLQ
DVHNFVALGA SIVHRDGGSQ RPRKKEDNVL VESHQKSLGE ADKAAVDVLI KAKPQ
