PTHY_RAT
ID PTHY_RAT Reviewed; 115 AA.
AC P04089; Q63473;
DT 01-NOV-1986, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1986, sequence version 1.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Parathyroid hormone;
DE Short=PTH;
DE AltName: Full=Parathyrin;
DE Flags: Precursor;
GN Name=Pth;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=6321505; DOI=10.1016/s0021-9258(17)43297-2;
RA Heinrich G., Kronenberg H.M., Potts J.T. Jr., Habener J.F.;
RT "Gene encoding parathyroid hormone. Nucleotide sequence of the rat gene and
RT deduced amino acid sequence of rat preproparathyroid hormone.";
RL J. Biol. Chem. 259:3320-3329(1984).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=3628009; DOI=10.1093/nar/15.16.6740;
RA Schmelzer H.-J., Gross G., Widera G., Mayer H.;
RT "Nucleotide sequence of a full-length cDNA clone encoding preproparathyroid
RT hormone from pig and rat.";
RL Nucleic Acids Res. 15:6740-6740(1987).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 10-115.
RC TISSUE=Parathyroid;
RA Schmelzer H.J., Gross G., Mayer H.;
RT "Nucleotide sequence of cloned cDNA encoding rat prepro parathyroid
RT hormone.";
RL Adv. Gene Technol. 21:228-229(1984).
RN [4]
RP NUCLEOTIDE SEQUENCE OF 32-115.
RC STRAIN=Sprague-Dawley; TISSUE=Brain, Liver, and Parathyroid;
RX PubMed=7588314; DOI=10.1210/endo.136.12.7588314;
RA Nutley M.T., Parimi S.A., Harvey S.;
RT "Sequence analysis of hypothalamic parathyroid hormone messenger
RT ribonucleic acid.";
RL Endocrinology 136:5600-5607(1995).
CC -!- FUNCTION: PTH elevates calcium level by dissolving the salts in bone
CC and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-
CC glucose (2DG) transport and glycogen synthesis in osteoblastic cells
CC (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with PTH1R (via N-terminal extracellular domain).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Hypothalamus and parathyroid gland.
CC -!- SIMILARITY: Belongs to the parathyroid hormone family. {ECO:0000305}.
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DR EMBL; K01268; AAA41979.1; -; Genomic_DNA.
DR EMBL; X05721; CAA29192.1; -; mRNA.
DR EMBL; M54875; AAA57156.1; -; mRNA.
DR EMBL; S80127; -; NOT_ANNOTATED_CDS; mRNA.
DR PIR; A05091; A05091.
DR RefSeq; NP_058740.1; NM_017044.1.
DR AlphaFoldDB; P04089; -.
DR SMR; P04089; -.
DR CORUM; P04089; -.
DR STRING; 10116.ENSRNOP00000019199; -.
DR PaxDb; P04089; -.
DR Ensembl; ENSRNOT00000019199; ENSRNOP00000019199; ENSRNOG00000014318.
DR GeneID; 24694; -.
DR KEGG; rno:24694; -.
DR UCSC; RGD:3440; rat.
DR CTD; 5741; -.
DR RGD; 3440; Pth.
DR eggNOG; ENOG502SB2W; Eukaryota.
DR GeneTree; ENSGT00390000018603; -.
DR HOGENOM; CLU_164143_0_0_1; -.
DR InParanoid; P04089; -.
DR OMA; HNLGEHR; -.
DR OrthoDB; 1482128at2759; -.
DR PhylomeDB; P04089; -.
DR TreeFam; TF336197; -.
DR Reactome; R-RNO-373080; Class B/2 (Secretin family receptors).
DR PRO; PR:P04089; -.
DR Proteomes; UP000002494; Chromosome 1.
DR Bgee; ENSRNOG00000014318; Expressed in stomach and 1 other tissue.
DR Genevisible; P04089; RN.
DR GO; GO:0005615; C:extracellular space; IDA:RGD.
DR GO; GO:0005179; F:hormone activity; IMP:CAFA.
DR GO; GO:0031856; F:parathyroid hormone receptor binding; IDA:RGD.
DR GO; GO:0051428; F:peptide hormone receptor binding; IMP:CAFA.
DR GO; GO:0047485; F:protein N-terminus binding; ISO:RGD.
DR GO; GO:0048018; F:receptor ligand activity; IMP:CAFA.
DR GO; GO:0031857; F:type 1 parathyroid hormone receptor binding; IDA:RGD.
DR GO; GO:0007202; P:activation of phospholipase C activity; ISO:RGD.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IDA:MGI.
DR GO; GO:0030282; P:bone mineralization; ISO:RGD.
DR GO; GO:0045453; P:bone resorption; TAS:RGD.
DR GO; GO:0055074; P:calcium ion homeostasis; ISO:RGD.
DR GO; GO:0007267; P:cell-cell signaling; IDA:RGD.
DR GO; GO:0006874; P:cellular calcium ion homeostasis; IDA:MGI.
DR GO; GO:0034645; P:cellular macromolecule biosynthetic process; ISO:RGD.
DR GO; GO:0048873; P:homeostasis of number of cells within a tissue; ISO:RGD.
DR GO; GO:0010960; P:magnesium ion homeostasis; ISO:RGD.
DR GO; GO:0071866; P:negative regulation of apoptotic process in bone marrow cell; ISO:RGD.
DR GO; GO:1900158; P:negative regulation of bone mineralization involved in bone maturation; IMP:CAFA.
DR GO; GO:0032331; P:negative regulation of chondrocyte differentiation; IMP:CAFA.
DR GO; GO:0010629; P:negative regulation of gene expression; ISO:RGD.
DR GO; GO:0001503; P:ossification; TAS:RGD.
DR GO; GO:0055062; P:phosphate ion homeostasis; ISO:RGD.
DR GO; GO:0030501; P:positive regulation of bone mineralization; IDA:RGD.
DR GO; GO:0071864; P:positive regulation of cell proliferation in bone marrow; ISO:RGD.
DR GO; GO:0046326; P:positive regulation of glucose import; ISS:UniProtKB.
DR GO; GO:0045725; P:positive regulation of glycogen biosynthetic process; ISS:UniProtKB.
DR GO; GO:0060732; P:positive regulation of inositol phosphate biosynthetic process; ISO:RGD.
DR GO; GO:0045778; P:positive regulation of ossification; IDA:RGD.
DR GO; GO:0090290; P:positive regulation of osteoclast proliferation; ISO:RGD.
DR GO; GO:0009967; P:positive regulation of signal transduction; ISO:RGD.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0010468; P:regulation of gene expression; ISO:RGD.
DR GO; GO:0046686; P:response to cadmium ion; IEP:RGD.
DR GO; GO:0045471; P:response to ethanol; IEP:RGD.
DR GO; GO:0071774; P:response to fibroblast growth factor; IEP:RGD.
DR GO; GO:0010288; P:response to lead ion; IEP:RGD.
DR GO; GO:0031667; P:response to nutrient levels; IEP:RGD.
DR GO; GO:0071107; P:response to parathyroid hormone; IEP:RGD.
DR GO; GO:0033280; P:response to vitamin D; IEP:RGD.
DR GO; GO:0009410; P:response to xenobiotic stimulus; IEP:RGD.
DR GO; GO:0007266; P:Rho protein signal transduction; IMP:RGD.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IEA:Ensembl.
DR InterPro; IPR003625; PTH.
DR InterPro; IPR001415; PTH/PTH-rel.
DR PANTHER; PTHR10541; PTHR10541; 1.
DR Pfam; PF01279; Parathyroid; 1.
DR PIRSF; PIRSF001832; PTH; 1.
DR SMART; SM00087; PTH; 1.
DR PROSITE; PS00335; PARATHYROID; 1.
PE 2: Evidence at transcript level;
KW Cleavage on pair of basic residues; Hormone; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..25
FT PROPEP 26..31
FT /id="PRO_0000023255"
FT CHAIN 32..115
FT /note="Parathyroid hormone"
FT /id="PRO_0000023256"
FT REGION 51..69
FT /note="Important for receptor binding"
FT /evidence="ECO:0000250"
FT REGION 76..101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 18
FT /note="C -> Y (in Ref. 3; AAA57156)"
FT /evidence="ECO:0000305"
FT CONFLICT 23
FT /note="A -> T (in Ref. 3; AAA57156)"
FT /evidence="ECO:0000305"
FT CONFLICT 33
FT /note="V -> I (in Ref. 3; AAA57156)"
FT /evidence="ECO:0000305"
FT CONFLICT 62
FT /note="V -> G (in Ref. 3; AAA57156)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 115 AA; 12722 MW; 7B434CFCA528B230 CRC64;
MMSASTMAKV MILMLAVCLL TQADGKPVKK RAVSEIQLMH NLGKHLASVE RMQWLRKKLQ
DVHNFVSLGV QMAAREGSYQ RPTKKEENVL VDGNSKSLGE GDKADVDVLV KAKSQ
