ID   AAD3_YEAST              Reviewed;         363 AA.
AC   P25612; D6VRA7;
DT   01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1992, sequence version 1.
DT   03-AUG-2022, entry version 148.
DE   RecName: Full=Putative aryl-alcohol dehydrogenase AAD3;
DE            EC=1.1.1.-;
GN   Name=AAD3; OrderedLocusNames=YCR107W;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=1574125; DOI=10.1038/357038a0;
RA   Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M.,
RA   Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G.,
RA   Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A.,
RA   Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M., Carcano C.,
RA   Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M.,
RA   Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C.,
RA   Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F.,
RA   Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C.,
RA   Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E.,
RA   Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P.,
RA   Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J.,
RA   Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P.,
RA   Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M.,
RA   Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P.,
RA   Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G.,
RA   Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E.,
RA   Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F.,
RA   Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L.,
RA   Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J.,
RA   Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M.,
RA   Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A.,
RA   Richterich P., Roberts A.B., Rodriguez F., Sanz E.,
RA   Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J.,
RA   Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I.,
RA   Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M.,
RA   Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M.,
RA   Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D.,
RA   Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K.,
RA   Sgouros J.G.;
RT   "The complete DNA sequence of yeast chromosome III.";
RL   Nature 357:38-46(1992).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
CC   -!- SIMILARITY: Belongs to the aldo/keto reductase family. Aldo/keto
CC       reductase 2 subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X59720; CAA42239.1; -; Genomic_DNA.
DR   EMBL; BK006937; DAA07576.1; -; Genomic_DNA.
DR   PIR; S19419; S19419.
DR   RefSeq; NP_010032.1; NM_001178814.1.
DR   AlphaFoldDB; P25612; -.
DR   SMR; P25612; -.
DR   BioGRID; 31079; 37.
DR   DIP; DIP-2610N; -.
DR   IntAct; P25612; 3.
DR   MINT; P25612; -.
DR   STRING; 4932.YCR107W; -.
DR   PaxDb; P25612; -.
DR   EnsemblFungi; YCR107W_mRNA; YCR107W; YCR107W.
DR   GeneID; 850471; -.
DR   KEGG; sce:YCR107W; -.
DR   SGD; S000000704; AAD3.
DR   VEuPathDB; FungiDB:YCR107W; -.
DR   eggNOG; KOG1575; Eukaryota.
DR   GeneTree; ENSGT00940000176306; -.
DR   HOGENOM; CLU_023205_2_2_1; -.
DR   InParanoid; P25612; -.
DR   OMA; MALCPWN; -.
DR   BioCyc; YEAST:YCR107W-MON; -.
DR   PRO; PR:P25612; -.
DR   Proteomes; UP000002311; Chromosome III.
DR   RNAct; P25612; protein.
DR   GO; GO:0047681; F:aryl-alcohol dehydrogenase (NADP+) activity; ISS:SGD.
DR   GO; GO:0006081; P:cellular aldehyde metabolic process; ISS:SGD.
DR   Gene3D; 3.20.20.100; -; 1.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   SUPFAM; SSF51430; SSF51430; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase; Reference proteome.
FT   CHAIN           1..363
FT                   /note="Putative aryl-alcohol dehydrogenase AAD3"
FT                   /id="PRO_0000070365"
SQ   SEQUENCE   363 AA;  40911 MW;  FFC74519895671DC CRC64;
     MIGSASDSSS KLGRLRFLSE TAAIKVSPLI LGEVSYDGAR SDFLKSMNKN RAFELLDTFY
     EAGGNFIDAA NNCQNEQSEE WIGEWIQSRR LRDQIVIATK FIKSDKKYKA GESNTANYCG
     NHKRSLHVSV RDSLRKLQTD WIDILYVHWW DYMSSIEEFM DSLHILVQQG KVLYLGVSDT
     PAWVVSAANY YATSYGKTPF SIYQGKWNVL NRDFERDIIP MARHFGMALA PWDVMGGGRF
     QSKKAMEERR KNGEGIRSFV GASEQTDAEI KISEALAKIA EEHGTESVTA IAIAYVRSKA
     KNFFPSVEGG KIEDLKENIK ALSIDLTPDN IKYLESIVPF DIGFPNNFIV LNSLTQKYGT
     NNV