AAD4_YEAST
ID AAD4_YEAST Reviewed; 329 AA.
AC Q07747; D6VRB4;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Probable aryl-alcohol dehydrogenase AAD4;
DE EC=1.1.1.-;
GN Name=AAD4; OrderedLocusNames=YDL243C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169867;
RA Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G.,
RA Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C.,
RA Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F.,
RA Delaveau T., del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M.,
RA Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T.,
RA Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C.,
RA Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S.,
RA Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L.,
RA Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H.,
RA Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M.,
RA Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M.,
RA Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A.,
RA Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G.,
RA Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E.,
RA Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S.,
RA Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D.,
RA Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V.,
RA Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E.,
RA Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M.,
RA Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D.,
RA Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X.,
RA Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A.,
RA Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R.,
RA Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T.,
RA Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L.,
RA Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E.,
RA Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L.,
RA Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M.,
RA Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K.,
RA Mewes H.-W., Zollner A., Zaccaria P.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.";
RL Nature 387:75-78(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP INDUCTION.
RX PubMed=10581269; DOI=10.1093/genetics/153.4.1591;
RA Delneri D., Gardner D.C.J., Oliver S.G.;
RT "Analysis of the seven-member AAD gene set demonstrates that genetic
RT redundancy in yeast may be more apparent than real.";
RL Genetics 153:1591-1600(1999).
CC -!- INDUCTION: By oxidative stress. {ECO:0000269|PubMed:10581269}.
CC -!- SIMILARITY: Belongs to the aldo/keto reductase family. Aldo/keto
CC reductase 2 subfamily. {ECO:0000305}.
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DR EMBL; Z74291; CAA98823.1; -; Genomic_DNA.
DR EMBL; BK006938; DAA11624.1; -; Genomic_DNA.
DR PIR; S67807; S67807.
DR RefSeq; NP_010038.1; NM_001180303.1.
DR AlphaFoldDB; Q07747; -.
DR SMR; Q07747; -.
DR BioGRID; 31869; 132.
DR DIP; DIP-5172N; -.
DR IntAct; Q07747; 2.
DR STRING; 4932.YDL243C; -.
DR PaxDb; Q07747; -.
DR EnsemblFungi; YDL243C_mRNA; YDL243C; YDL243C.
DR GeneID; 851354; -.
DR KEGG; sce:YDL243C; -.
DR SGD; S000002402; AAD4.
DR VEuPathDB; FungiDB:YDL243C; -.
DR eggNOG; KOG1575; Eukaryota.
DR GeneTree; ENSGT00940000176306; -.
DR HOGENOM; CLU_023205_2_2_1; -.
DR InParanoid; Q07747; -.
DR OMA; SNYLGWQ; -.
DR BioCyc; YEAST:YDL243C-MON; -.
DR PRO; PR:Q07747; -.
DR Proteomes; UP000002311; Chromosome IV.
DR RNAct; Q07747; protein.
DR GO; GO:0047681; F:aryl-alcohol dehydrogenase (NADP+) activity; IDA:SGD.
DR GO; GO:0006081; P:cellular aldehyde metabolic process; ISS:SGD.
DR Gene3D; 3.20.20.100; -; 1.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR SUPFAM; SSF51430; SSF51430; 1.
PE 2: Evidence at transcript level;
KW NADP; Oxidoreductase; Reference proteome; Stress response.
FT CHAIN 1..329
FT /note="Probable aryl-alcohol dehydrogenase AAD4"
FT /id="PRO_0000070366"
FT ACT_SITE 30
FT /note="Proton donor"
FT /evidence="ECO:0000250"
FT BINDING 105
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 190..200
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000250"
FT SITE 57
FT /note="Lowers pKa of active site Tyr"
FT /evidence="ECO:0000250"
SQ SEQUENCE 329 AA; 36977 MW; 62DBDD0C889610E0 CRC64;
MGSMNKEQAF ELLDAFYEAG GNCIDTANSY QNEESEIWIG EWMKSRKLRD QIVIATKFTG
DYKKYEVGGG KSANYCGNHK HSLHVSVRDS LRKLQTDWID ILYVHWWDYM SSIEEVMDSL
HILVQQGKVL YLGVSDTPAW VVSAANYYAT SHGKTPFSIY QGKWNVLNRD FERDIIPMAR
HFGMALAPWD VMGGGRFQSK KAMEERKKNG EGLRTVSGTS KQTDKEVKIS EALAKVAEEH
GTESVTAIAI AYVRSKAKNV FPLVGGRKIE HLKQNIEALS IKLTPEQIEY LESIIPFDVG
FPTNFIGDDP AVTKKASLLT AMSAQISFD
